Zobrazeno 1 - 10
of 211
pro vyhledávání: '"PARP, poly ADP ribose polymerase"'
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/2bd1435aaaf148319a8ed194ce3bcc19
Autor:
Máté Bencsics, Bálint Bányai, Haoran Ke, Roland Csépányi-Kömi, Péter Sasvári, Françoise Dantzer, Najat Hanini, Rita Benkő, Eszter M. Horváth
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionT cell-dependent inflammatory response with the upregulation of helper 17 T cells (Th17) and the downregulation of regulatory T cells (Treg) accompanied by the increased production of tumor necrosis alpha (TNFa) is characteristic of infla
Externí odkaz:
https://doaj.org/article/9d311cf606b446dc9f4f38bcc452623d
Autor:
Harish R. Krishnan, Gian Paolo Vallerini, Hannah E. Gavin, Marina Guizzetti, Hooriyah S. Rizavi, David P. Gavin, Rajiv P. Sharma
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
We report on the effects of ethanol (EtOH) and Poly (ADP-ribose) polymerase (PARP) inhibition on RNA ribosomal engagement, as a proxy for protein translation, in prefrontal cortical (PFC) pyramidal neurons. We hypothesized that EtOH induces a shift i
Externí odkaz:
https://doaj.org/article/e8c583c98e94474d810827584b3aeb76
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Introduction: Poly ADP-Ribose Polymerase-1 (PARP1), a DNA repair enzyme is implicated as a key molecule in the pathogenesis of several neurodegenerative disorders. Traumatic insults inducing oxidative stress results in its over-activation causing inf
Externí odkaz:
https://doaj.org/article/3caddd2109d84616b5f5afe585755da8
Autor:
Tingting Du, Zhihui Zhang, Jie Zhou, Li Sheng, Haiping Yao, Ming Ji, Bailing Xu, Xiaoguang Chen
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
PARP inhibitors have clinically demonstrated good antitumor activity in patients with BRCA mutations. Here, we described YHP-836, a novel PARP inhibitor, YHP-836 demonstrated excellent inhibitory activity for both PARP1 and PARP2 enzymes. It also all
Externí odkaz:
https://doaj.org/article/92e17dc392634eca811e8d81a769ae31
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Poly(ADP-ribose)polymerase-1 (PARP1) is a DNA repair enzyme highly expressed in the nuclei of mammalian cells, with a structure and function that have attracted interest since its discovery. PARP inhibitors, moreover, can be used to induce synthetic
Externí odkaz:
https://doaj.org/article/cc5af923006348f2a7dc040330feceab
Publikováno v:
Biomedicines, Vol 9, Iss 11, p 1512 (2021)
Triple-negative breast cancer is a combative cancer type with a highly inflated histological grade that leads to poor theragnostic value. Gene, protein, and receptor-specific targets have shown effective clinical outcomes in patients with TNBC. Cells
Externí odkaz:
https://doaj.org/article/108999712fb24e77aa9273b0efcdafe2
Autor:
Shiv K. Gupta, Emily J. Smith, Ann C. Mladek, Shulan Tian, Paul A. Decker, Sani H. Kizilbash, Gaspar J. Kitange, Jann N. Sarkaria
Publikováno v:
Frontiers in Oncology, Vol 8 (2019)
Prognosis of patients with glioblastoma (GBM) remains dismal despite maximal surgical resection followed by aggressive chemo-radiation therapy. Almost every GBM, regardless of genotype, relapses as aggressive recurrent disease. Sensitization of GBM c
Externí odkaz:
https://doaj.org/article/aadda5d7499241cebbf1b673ba724aab
Autor:
Yanfei Cai, Jingyu Zhu, Yun Chen, Jian Jin, Xinling Zhao, Kan Li, Lei Xu, Huazhong Li, Gang Huang
Publikováno v:
Journal of Advanced Research
Journal of Advanced Research, Vol 36, Iss, Pp 1-13 (2022)
Journal of Advanced Research, Vol 36, Iss, Pp 1-13 (2022)
Graphical abstract
Highlights • Virtual screening based on machine learning with multiple proteins was developed. • Discovery of a novel PI3Kγ inhibitor integrating virtual screening and bio-assays. • JN-KI3 selective inhibit PI3Kγ enzym
Highlights • Virtual screening based on machine learning with multiple proteins was developed. • Discovery of a novel PI3Kγ inhibitor integrating virtual screening and bio-assays. • JN-KI3 selective inhibit PI3Kγ enzym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cdbf7fb8f578b72a0c3242e69513c71
https://doi.org/10.1016/j.jare.2021.04.007
https://doi.org/10.1016/j.jare.2021.04.007
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 24, Iss 1, Pp 34-49 (2022)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
Highlights • GNF-7, a multi-targeted kinase inhibitor, is highly potent against FGFR4. • GNF-7 and SIJ1263 are highly potent on Ba/F3 cells with wtFGFR4 or mtFGFR4. • GNF-7 and SIJ1263 are highly potent on HCC cells with FGFR4 activation. • G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4404b111edeadaa6237d4a7297c304e
https://doi.org/10.1016/j.neo.2021.11.011
https://doi.org/10.1016/j.neo.2021.11.011