Insights into the Current and Possible Future Use of Opioid Antagonists in Relation to Opioid-Induced Constipation and Dysbiosis

Autor: Nariman Essmat, Dávid Árpád Karádi, Ferenc Zádor, Kornél Király, Susanna Fürst, Mahmoud Al-Khrasani

Publikováno v: Molecules, Vol 28, Iss 23, p 7766 (2023)

Opioid receptor agonists, particularly those that activate µ-opioid receptors (MORs), are essential analgesic agents for acute or chronic mild to severe pain treatment. However, their use has raised concerns including, among others, intestinal dysbi

Externí odkaz: https://doaj.org/article/96c59c3c6c4c4ed79c68127a836304a5

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The Impact of P-Glycoprotein on Opioid Analgesics: What's the Real Meaning in Pain Management and Palliative Care?

Autor: Flaminia Coluzzi, Maria Sole Scerpa, Monica Rocco, Diego Fornasari

Opioids are widely used in cancer and non-cancer pain management. However, many transporters at the blood–brain barrier (BBB), such as P-glycoprotein (P-gp, ABCB1/MDR1), may impair their delivery to the brain, thus leading to opioid tolerance. None

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d37ceefe52aa04f72db807b852c4276
https://hdl.handle.net/2434/948369

Antagonists of the Mu-Opioid Receptor in the Cancer Patient: Fact or Fiction?

Autor: Belltall A, Mazzinari G, Diaz-Cambronero O, Eroles P, Navarro M

Publikováno v: Current Oncology Reports
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
Consejo Superior de Investigaciones Científicas (CSIC)

Purpose of Review Antagonists of mu-opioid receptor role in cancer progression remains to be elucidated. The objective of this review was to summarize the available evidence on antagonists of mu-opioid receptor effect on tumor progression and prognos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::f456f2393d06a7a22b582a385625c99c
https://www.fundanet.incliva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=16603

Opioid-Induced Constipation in Real-World Practice: A Physician Survey, 1 Year Later

Autor: Domenico Alvaro, Flaminia Coluzzi, Walter Gianni, Fabio Lugoboni, Franco Marinangeli, Giuseppe Massazza, Carmine Pinto, Giustino Varrassi

Publikováno v: Pain and therapy. 11(2)

Opioid-induced constipation (OIC) is the most common adverse effect of opioid therapy, but it is underdiagnosed and undertreated. Last year, a survey among Italian healthcare providers revealed important differences in the clinical management of OIC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::488e990b0cbf52ffe350b230043636d0
https://pubmed.ncbi.nlm.nih.gov/35122615