Human IgG lacking effector functions demonstrate lower FcRn-binding and reduced transplacental transport

Autor: Stapleton, Nigel M., Armstrong-Fisher, Sylvia S., Andersen, Jan Terje, van der Schoot, C. Ellen, Porter, Charlene, Page, Kenneth R., Falconer, Donald, de Haas, Masja, Williamson, Lorna M., Clark, Michael R., Vidarsson, Gestur, Armour, Kathryn L.

Publikováno v: Stapleton, Nigel M. Armstrong-Fisher, Sylvia S. Andersen, Jan Terje van der Schoot, C. Ellen Porter, Charlene Page, Kenneth R. Falconer, Donald de Haas, Masja Williamson, Lorna M. Clark, Michael R. Vidarsson, Gestur Armour, Kathryn L. . Human IgG lacking effector functions demonstrate lower FcRn-binding and reduced transplacental transport. Molecular Immunology. 2018, 95, 1-9
Molecular Immunology

Externí odkaz: http://hdl.handle.net/10852/71654
https://www.duo.uio.no/bitstream/handle/10852/71654/1/Stapleton_Cristin-post%2B1593315.pdf

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Human IgG lacking effector functions demonstrate lower FcRn-binding and reduced transplacental transport.

Autor: Stapleton NM; Department of Experimental Immunohematology, Sanquin Research, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Plesmanlaan 125, Amsterdam, 1066 CX, The Netherlands., Armstrong-Fisher SS; RDI Clinical Transfusion Group, Scottish National Blood Transfusion Service, Foresterhill, Aberdeen, AB25 2ZW, UK; Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK., Andersen JT; Department of Immunology, Oslo University Hospital Rikshospitalet and University of Oslo, PO Box 4950, Nydalen, Oslo, 0424, Norway; Centre for Immune Regulation and Department of Biosciences, University of Oslo, PO box 1041, Blindern, Oslo, 0316, Norway; Department of Pharmacology, Institute of Clinical Medicine, University of Oslo and Oslo University Hospital, Problemveien 7, 0315, Oslo, Norway., van der Schoot CE; Department of Experimental Immunohematology, Sanquin Research, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Plesmanlaan 125, Amsterdam, 1066 CX, The Netherlands., Porter C; Immunology Laboratory, Department of Pathology, Aberdeen Royal Infirmary, Aberdeen, AB25 2ZB, UK., Page KR; Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK., Falconer D; Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK., de Haas M; Department of Experimental Immunohematology, Sanquin Research, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Plesmanlaan 125, Amsterdam, 1066 CX, The Netherlands., Williamson LM; Department of Haematology, University of Cambridge, UK; NHS Blood and Transplant, Long Road, Cambridge, CB2 2PT, UK., Clark MR; Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK., Vidarsson G; Department of Experimental Immunohematology, Sanquin Research, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Plesmanlaan 125, Amsterdam, 1066 CX, The Netherlands. Electronic address: G.Vidarsson@sanquin.nl., Armour KL; Department of Haematology, University of Cambridge, UK; Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK.

Publikováno v: Molecular immunology [Mol Immunol] 2018 Mar; Vol. 95, pp. 1-9. Date of Electronic Publication: 2018 Feb 20.