How to Simplify the Evaluation of Newly Introduced Chemotherapeutic Interventions in Myeloma

Autor: David A Cairns, Alberto Alvarez-Iglesias, Helen Enright, Tracey McGuigan, M. Drake, Gordon Cook, Rakesh Popat, Heather Oakervee, Jamie Cavenagh, Tanya O’Shea, Maeve Leahy, P Kettle, Michael O'Dwyer, Treen C. M. Morris, Kwee Yong

Publikováno v: Morris, T C M, Drake, M B, Kettle, P J, McGuigan, T, Leahy, M, O'Dwyer, M, Enright, H, O'Shea, T, Popat, R, Oakervee, H E, Yong, K, Cavenagh, J D, Cairns, D A, Alvarez-Iglesias, A & Cook, G 2021, ' How to Simplify the Evaluation of Newly Introduced Chemotherapeutic Interventions in Myeloma ', Clinical hematology international, vol. 3, no. 1, pp. 27-33 . https://doi.org/10.2991/chi.k.210201.001
Clinical Hematology International, Vol 3, Iss 1 (2021)
Clinical Hematology International

When the bortezomib [PS341], adriamycin and dexamethasone (PAD) regimen was first evaluated, the response rate in untreated patients was much superior to that elicited by conventional chemotherapeutic agents. We demonstrated the efficacy of PAD in re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc5de9777f3b787aeec01a78b049bf23
https://pure.qub.ac.uk/en/publications/f92919e9-c0f1-4ad7-83d8-287eab7c95c1

Elucidating the beneficial effects of melphalan, adriamycin, and corticoids in combination with bortezomib against multiple myeloma in vitro

Autor: Dirk Theile, Johanna Weiss, Jürgen Burhenne, Julia Schäfer

Publikováno v: Naunyn-Schmiedeberg's archives of pharmacology. 392(4)

Combining bortezomib with other anti-cancer drugs or glucocorticoids is more efficient in multiple myeloma than bortezomib alone. However, the molecular mechanism of this beneficial effect is largely unknown. To investigate the effects of these compo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb041c61cb05d88d66f9ed22b84d0d2
https://pubmed.ncbi.nlm.nih.gov/30554340

Retrospective Study of the Efficacy and Safety of Treatment with Subcutaneous Injection of Bortezomib in De Novo Patients with MM

Autor: Chengcheng Fu, Hui Liu, Shuang Yan, Yun Xu, Ling Ma, Wu Depei

Publikováno v: Blood. 126:5074-5074

[Objective] The induction therapy of multiple myeloma (MM) has dramatically changed due to the availability of new drugs such as bortezomib.To explore the efficacy and safety of subcutaneous injection of bortezomib in the treatment of de novo MM pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8920401b59177a80af2b601123b976b4
https://doi.org/10.1182/blood.v126.23.5074.5074

Bortezomib-Based Induction Overcomes Effect of 1q Amplification On Response in Newly-Diagnosed Myeloma and Results in Similar 2 Year Event-Free Survival

Autor: Jacquelyn Wade, Andrew Spencer, Noemi Horvath, John Bashford, Eleanor Ashurst, Miles Prince, Lynda J. Campbell, Mark Hertzberg, Belinda Butcher, Douglas E. Joshua, Bradley Auguston, Michael C. Copeman

Publikováno v: Blood. 120:4065-4065

Abstract 4065 Background: Amplification of chromosome 1q occurs in 40% of myeloma and predicts lower response to induction regimens. We assessed if a PAD regimen overcomes effects of 1q amplification on overall response rate (ORR), event-free (EFS) a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fef5d7c4944f863245e38aa3a0697865
https://doi.org/10.1182/blood.v120.21.4065.4065

Total Body Irradiation (TBI) or Busulfan (Bu) Plus High Dose Melphalan After Bortezomib (Bz) Containing Regimen As Front Line Treatment of High Risk Multiple Myeloma (MM) Patients with 17p Deletion and/or t(4;14) Translocation

Autor: Lionel Karlin, Bertrand Arnulf, Stephanie Harel, Raphael Szalat, Jean Paul Fermand, Bouchra Asli, Jean Soulier, Marion Malphettes

Publikováno v: Blood. 118:4501-4501

Abstract 4501 Despite recent improvement of overall survival of MM due to the use of novel agents, the high risk sub group of patients, especially with 17p deletion and/or t(4;14) still have a poor prognosis. New therapeutic strategies are needed to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19701c21d069b533417be29f2f9be898
https://doi.org/10.1182/blood.v118.21.4501.4501