Zobrazeno 1 - 10
of 4 842
pro vyhledávání: '"PACAP"'
Autor:
Song Guo, Rikke Holm Rasmussen, Anders Hay-Schmidt, Messoud Ashina, Ayodeji A. Asuni, Jeppe Møller Jensen, Anja Holm, Sabrina Prehn Lauritzen, Glenn Dorsam, Jens Hannibal, Birgitte Georg, David Møbjerg Kristensen, Jes Olesen, Sarah Louise Christensen
Publikováno v:
The Journal of Headache and Pain, Vol 25, Iss 1, Pp 1-12 (2024)
Abstract Background Pituitary adenylate cyclase-activating peptide (PACAP) is a neuropeptide pivotal in migraine pathophysiology and is considered a promising new migraine drug target. Although intravenous PACAP triggers migraine attacks and a recent
Externí odkaz:
https://doaj.org/article/1b5638b4204d4c57a3832603fc0281f0
Autor:
Hai-Lou Zhang, Yan Sun, Zhang-Jie Wu, Ying Yin, Rui-Yi Liu, Ji-Chun Zhang, Zhang-Jin Zhang, Suk-Yu Yau, Hao-Xin Wu, Ti-Fei Yuan, Li Zhang, Miroslav Adzic, Gang Chen
Publikováno v:
Military Medical Research, Vol 11, Iss 1, Pp 1-16 (2024)
Abstract Background The development of ketamine-like rapid antidepressants holds promise for enhancing the therapeutic efficacy of depression, but the underlying cellular and molecular mechanisms remain unclear. Implicated in depression regulation, t
Externí odkaz:
https://doaj.org/article/5e32b48b85444f4e9503daa9887cd9a3
Autor:
Jes Olesen
Publikováno v:
The Journal of Headache and Pain, Vol 25, Iss 1, Pp 1-12 (2024)
Abstract Introduction The development of several experimental migraine provocation models has significantly contributed to an understanding of the signaling mechanisms of migraine. The early history of this development and a view to the future are pr
Externí odkaz:
https://doaj.org/article/9e53911bfcd84508bebd51adadfb5c3e
Autor:
MoXin Chen, XiaoYi Liang, XiRui Chen, Yuan Yang, Qin Shu, YaHan Ju, WanQin Nie, XueFeng Yang, YongLin Guo, XiaoJing Li, Ping Gu, Lin Li
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 179, Iss , Pp 117427- (2024)
Retinal ischemia is an ophthalmic emergency often caused by cardiovascular diseases, leading to irreversible vision loss and even blindness. Innovative retinal ischemia treatments are needed due to limited options. The pathological mechanisms involve
Externí odkaz:
https://doaj.org/article/d6b92374525d49c2aa61eda162ff2967
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract The natural alignment of animals into social dominance hierarchies produces adaptive, and potentially maladaptive, changes in the brain that influence health and behavior. Aggressive and submissive behaviors assumed by animals through domina
Externí odkaz:
https://doaj.org/article/0245adb2834e4742b03a941185ff8ad1
Autor:
Jesús Luis Betancourt, Tania Rodríguez-Ramos, Laura Rivera, Yamila Carpio, Mario Pablo Estrada, Laida Ramos, Brian Dixon
Publikováno v:
Comparative Immunology Reports, Vol 7, Iss , Pp 200177- (2024)
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a highly conserved multifunctional neuropeptide belonging to the secretin/glucagon/vasoactive intestinal peptide superfamily. In recent years, the role of PACAP in immunoregulation has bee
Externí odkaz:
https://doaj.org/article/76f76818bdba48359e6b7bc1957c156b
Autor:
Reto B Cola, Salome N Niethammer, Preethi Rajamannar, Andrea Gresch, Musadiq A Bhat, Kevin Assoumou, Elyse T Williams, Patrick Hauck, Nina Hartrampf, Dietmar Benke, Miriam Stoeber, Gil Levkowitz, Sarah Melzer, Tommaso Patriarchi
Publikováno v:
eLife, Vol 13 (2024)
Class-B1 G-protein-coupled receptors (GPCRs) are an important family of clinically relevant drug targets that remain difficult to investigate via high-throughput screening and in animal models. Here, we engineered PAClight1P78A, a novel genetically e
Externí odkaz:
https://doaj.org/article/83a204a88f8b464d90811cb0b5e39796
Publikováno v:
Guoji Yanke Zazhi, Vol 23, Iss 12, Pp 2035-2039 (2023)
AIM: To investigate the effects of ginsenoside Rg1 injection combined with inosine tablets and vitamin B1 on serum brain-derived neurotrophic factor(BDNF), pituitary adenylate cyclase activating polypeptide(PACAP)and clinical efficacy in primary reti
Externí odkaz:
https://doaj.org/article/1e9f58c5646d42b396bd248da0c1c399
Publikováno v:
Toxins, Vol 16, Iss 10, p 427 (2024)
Post-traumatic headache (PTH) is a common and debilitating consequence of traumatic brain injury (TBI), often resembling migraine and tension-type headaches. Despite its prevalence, the optimal treatment for PTH remains unclear, with current strategi
Externí odkaz:
https://doaj.org/article/4599845ab77b4019b426595202c0ce2c
Autor:
Jason Sparks, Matyas Meggyes, Lilla Makszin, Viktoria Jehn, Hedvig Lugosi, Dora Reglodi, Laszlo Szereday
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 19, p 10676 (2024)
PACAP (pituitary adenylate cyclase activating polypeptide) is a widespread neuropeptide with cytoprotective and anti-inflammatory effects. It plays a role in innate and adaptive immunity, but data are limited about gut-associated lymphoid tissue. We
Externí odkaz:
https://doaj.org/article/7ba9a7aae7844f31a05720b4b68030ad