Zobrazeno 1 - 10
of 31
pro vyhledávání: '"PABLA AGUIRRE"'
Autor:
Olimpo García-Beltrán, Natalia P Mena, Pabla Aguirre, Germán Barriga-González, Antonio Galdámez, Edgar Nagles, Tatiana Adasme, Cecilia Hidalgo, Marco T Núñez
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189043 (2017)
Iron accumulation, oxidative stress and calcium signaling dysregulation are common pathognomonic signs of several neurodegenerative diseases, including Parkinson´s and Alzheimer's diseases, Friedreich ataxia and Huntington's disease. Given their the
Externí odkaz:
https://doaj.org/article/07513b7a3cd840afac3e9920a4d04929
Publikováno v:
Parkinson's Disease, Vol 2016 (2016)
Mitochondrial dysfunction, iron accumulation, and oxidative damage are conditions often found in damaged brain areas of Parkinson’s disease. We propose that a causal link exists between these three events. Mitochondrial dysfunction results not only
Externí odkaz:
https://doaj.org/article/496d35d3cc13478194e66efdbdd3c20e
Autor:
Pabla Aguirre, Natalia P Mena, Carlos M Carrasco, Yorka Muñoz, Patricio Pérez-Henríquez, Rodrigo A Morales, Bruce K Cassels, Carolina Méndez-Gálvez, Olimpo García-Beltrán, Christian González-Billault, Marco T Núñez
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144848 (2015)
Neuronal death in Parkinson's disease (PD) is often preceded by axodendritic tree retraction and loss of neuronal functionality. The presence of non-functional but live neurons opens therapeutic possibilities to recover functionality before clinical
Externí odkaz:
https://doaj.org/article/07e3dcd9b356406682ba92db1457d413
Publikováno v:
Biological Research, Vol 39, Iss 1, Pp 157-165 (2006)
Neurons, as non-dividing cells, encounter a myriad of stressful conditions throughout their lifespan. In particular, there is increasing evidence that iron progressively accumulates in the brain with age and that iron-induced oxidative stress is the
Externí odkaz:
https://doaj.org/article/a76d43e198904aaba11ecd3bf15ae6cd
Publikováno v:
Biological Research, Vol 39, Iss 1, Pp 189-190 (2006)
Recent evidence suggests that reactive oxygen species function as second messenger molecules in normal physiological processes. For example, activation of N-Methyl-D-Aspartate receptor results in the production of ROS, which appears to be critical fo
Externí odkaz:
https://doaj.org/article/a727cbbef168413f83783811d11858fc
Autor:
PABLA AGUIRRE, NATALIA MENA, VICTORIA TAPIA, ALEJANDRO ROJAS, MIGUEL ARREDONDO, MARCO TULIO NÚÑEZ
Publikováno v:
Biological Research, Vol 39, Iss 1, Pp 103-104 (2006)
Brain cells have a highly active oxidative metabolism, yet they contain only low to moderate superoxide dismutase and catalase activities. Thus, their antioxidant defenses rely mainly on cellular reduced glutathione levels. In this work, in cortical
Externí odkaz:
https://doaj.org/article/0f81f47fe976407e9782796c04479932
Publikováno v:
American Journal of Physiology-Cell Physiology. 323:C1791-C1806
Iron absorption is a complex and highly controlled process where DMT1 transports nonheme iron through the brush-border membrane of enterocytes to the cytoplasm but does not transport alkaline-earth metals such as calcium. However, it has been propose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d260387e3472e50e66f2647f39387cec
https://doi.org/10.1152/ajpcell.00411.2022
https://doi.org/10.1152/ajpcell.00411.2022
Autor:
Edgar Nagles, Margarita E. Aliaga, Camilo Segura, Marco T. Núñez, Olimpo García-Beltrán, Verónica Arancibia, Alexis Moya, Marisol Gómez, Pabla Aguirre
Publikováno v:
RSC Advances. 8:31261-31266
A new probe (E)-7-(diethylamino)-3-(3-(thiophen-2-yl)acryloyl)-2H-chromen-2-one (ChC16) was synthesized and studied as a turn-on fluorescent probe, based on a Michael addition mechanism for sensing SO2 derivatives, which is favored in the presence of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8ca5f0f6dd2d6434e0a4aaba1819d56
https://doi.org/10.1039/c8ra04526g
https://doi.org/10.1039/c8ra04526g
Autor:
Yorka Muñoz, Victoria Tapia, Bruce K. Cassels, Pabla Aguirre, Olimpo García-Beltrán, Marco T. Núñez
Publikováno v:
ACS Chemical Neuroscience. 8:178-185
Disturbed iron homeostasis, often coupled to mitochondrial dysfunction, plays an important role in the progression of common neurodegenerative diseases such as Parkinson’s disease (PD). Recent studies have underlined the relevance of iron chelation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ddd868cc41f8ebf71fe9e9651508986
https://doi.org/10.1021/acschemneuro.6b00309
https://doi.org/10.1021/acschemneuro.6b00309
Autor:
Marisol, Gómez, Margarita E, Aliaga, Verónica, Arancibia, Alexis, Moya, Camilo, Segura, Marco T, Nuñez, Pabla, Aguirre, Edgar, Nagles, Olimpo, García-Beltrán
Publikováno v:
RSC advances. 8(55)
A new probe (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::701e368e5755c378c958884e1c87145d
https://pubmed.ncbi.nlm.nih.gov/35548216
https://pubmed.ncbi.nlm.nih.gov/35548216