Zobrazeno 1 - 10
of 623
pro vyhledávání: '"P70S6 kinase"'
Autor:
Xiangdang Shi, Eva von Weltin, Emma Fitzsimmons, Chau Do, Carolina Caban Rivera, Chongguang Chen, Lee-Yuan Liu-Chen, Ellen M. Unterwald
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Mechanistic target of rapamycin (mTOR) C1 and its downstream effectors have been implicated in synaptic plasticity and memory. Our prior work demonstrated that reactivation of cocaine memory engages a signaling pathway consisting of Akt, glycogen syn
Externí odkaz:
https://doaj.org/article/9ce6582218524563975336a5db5daf95
Autor:
Brian H. Heasley, Jing Lin, Thomas F. N. Haxell, Igor Mochalkin, Constantin Neagu, Felix Rohdich, Ruoxi Lan, Amanda E. Sutton, Jennifer Jackson, Potnick Justin, Bayard R. Huck, Andreas Machl, Katrin Georgi, Xiaoling Chen, Sherer Brian A, Erik Wilker, Thomas E. Richardson, Anderson Clark, Reinaldo Jones, Johnson Theresa L, Lizbeth Celeste Deselm, Andreas Goutopoulos, Hui Tian, Yufang Xiao, Joseph A. Moore, Lindsey Crowley
Publikováno v:
Journal of Medicinal Chemistry. 64:14603-14619
Herein, we report the discovery of a novel class of quinazoline carboxamides as dual p70S6k/Akt inhibitors for the treatment of tumors driven by alterations to the PI3K/Akt/mTOR (PAM) pathway. Through the screening of in-house proprietary kinase libr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f0f668e1b7d0d3fdf120a40211a6894
https://doi.org/10.1021/acs.jmedchem.1c01087
https://doi.org/10.1021/acs.jmedchem.1c01087
Autor:
Jun-Yu Wang, Hua Fan
Publikováno v:
Chinese Medical Journal, Vol 128, Iss 5, Pp 664-669 (2015)
Background: The phosphorylation of p70S6 kinase (p70S6K) represents an important target for sensitive detection on pharmacodynamic effects of sirolimus, but the methods of assessing p70S6K phosphorylation are still unclear. The aim of this study was
Externí odkaz:
https://doaj.org/article/4b2c0981ca444f438f40079f7cebf418
Autor:
Leipert, Jenny, Kässner, Franziska, Schuster, Susanne, Händel, Norman, Körner, Antje, Kiess, Wieland, Garten, Antje
Patients with phosphatase and tensin homolog (PTEN) hamartoma tumor syndrome and germline mutations in PTEN frequently develop lipomatosis, for which there is no standard treatment. Rapamycin was shown to reduce the growth of lipoma cells with hetero
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A38595
https://ul.qucosa.de/api/qucosa%3A38595/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A38595/attachment/ATT-0/
Publikováno v:
British Journal of Neurosurgery. :1-9
Akt/mTOR/p70S6K signaling pathway promotes motor function recovery after spinal cord injury (SCI) in both neurons and astrocytes. But the role and mechanism of this pathway in oligodendrocytes during nerve repair following SCI has not been researched
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d706fa6eaaee29babc1fe84d83df5cb0
https://doi.org/10.1080/02688697.2020.1862056
https://doi.org/10.1080/02688697.2020.1862056
Publikováno v:
Science & Sports. 35:91-98
Summary Background Resistance training and spirulina change the expression of genes involved in the hypertrophy. We investigated the effect of resistance training with Spirulina platensis on PI3K/Akt/mTOR/p70S6k signaling pathway in rat cardiac muscl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98ce5fc26e10d203118df923c18abaec
https://doi.org/10.1016/j.scispo.2019.06.003
https://doi.org/10.1016/j.scispo.2019.06.003
Akademický článek
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Autor:
Hudson M. Holmes, Christopher G. Vann, Paul A. Roberson, Michael D. Roberts, Shelby C. Osburn, Matthew A. Romero, Petey W. Mumford, Carlton D. Fox, Cody T. Haun, Kaelin C. Young, C. Brooks Mobley
Publikováno v:
Journal of strength and conditioning research. 35(8)
Vann, CG, Haun, CT, Osburn, SC, Romero, MA, Roberson, PA, Mumford, PW, Mobley, CB, Holmes, HM, Fox, CD, Young, KC, and Roberts, MD. Molecular differences in skeletal muscle after 1 week of active vs. passive recovery from high-volume resistance train
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be243cc95e315a0ba31ec9ac57304c53
https://pubmed.ncbi.nlm.nih.gov/34138821
https://pubmed.ncbi.nlm.nih.gov/34138821
Publikováno v:
Physiological Reports, Vol 9, Iss 9, Pp n/a-n/a (2021)
Physiological Reports
Physiological Reports
Mechanistic target of rapamycin complex 1 (mTORC1) plays a central role in muscle protein synthesis and repeated bouts of resistance exercise (RE) blunt mTORC1 activation. However, the changes in the proteolytic signaling when recurrent RE bouts atte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2997d4dc66ceffad9b1fb3fc57add88e
https://doaj.org/article/631854e4f9474987affa26f09c73e4d9
https://doaj.org/article/631854e4f9474987affa26f09c73e4d9
Publikováno v:
International Journal of Immunopathology and Pharmacology
Glomerular mesangial cell (MC) proliferation is one of the causative factors of glomerular diseases and one of their prominent pathological features. Rapamycin can inhibit MC proliferation and slow the progression to chronic renal fibrosis. The prese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9eeae63c7f3754352426457f5bb6d1f
http://europepmc.org/articles/PMC8161859
http://europepmc.org/articles/PMC8161859