Zobrazeno 1 - 10
of 804
pro vyhledávání: '"P66shc"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Numerous studies have highlighted the pivotal role of mitochondria-related genes (MRGs) in the initiation and progression of glioblastoma (GBM). However, the specific contributions of MRGs coding proteins to GBM pathology remain incompletely
Externí odkaz:
https://doaj.org/article/cf0e16a792f443c58f87246f75515593
Autor:
Lulu Ji, Xiaoli Zhang, Zhiguo Chen, Yuexiao Wang, Hengxuan Zhu, Yaru Nai, Yanyi Huang, Rujie Lai, Yu Zhong, Xiting Yang, Qiongtao Wang, Hanyang Hu, Lin Wang
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background p66Shc, as a redox enzyme, regulates reactive oxygen species (ROS) production in mitochondria and autophagy. However, the mechanisms by which p66Shc affects autophagosome formation are not fully understood. Methods p66Shc expressi
Externí odkaz:
https://doaj.org/article/355dc557b67546e9957a01dcd9c6838a
Akademický článek
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Autor:
Sara Rossi, Vanessa Tatangelo, Maria Dichiara, Stefania Butini, Sandra Gemma, Simone Brogi, Silvia Pasquini, Martina Cappello, Fabrizio Vincenzi, Katia Varani, Ludovica Lopresti, Margherita Malchiodi, Chiara Carrara, Alessandro Gozzetti, Monica Bocchia, Giuseppe Marotta, Laura Patrussi, Gabriele Carullo, Cosima T. Baldari, Giuseppe Campiani
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 174, Iss , Pp 116537- (2024)
Chronic Lymphocytic Leukemia (CLL) patients have a defective expression of the proapoptotic protein p66Shc and of its transcriptional factor STAT4, which evoke molecular abnormalities, impairing apoptosis and worsening disease prognosis and severity.
Externí odkaz:
https://doaj.org/article/5b5fa73fa7a44b40b6f5ece58f9ee513
Autor:
Rafia A. Baba, Hilal A. Mir, Taseem A. Mokhdomi, Hina F. Bhat, Ajaz Ahmad, Firdous A. Khanday
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
P66Shc and Rac1 proteins are responsible for tumor-associated inflammation, particularly in brain tumors characterized by elevated oxidative stress and increased reactive oxygen species (ROS) production. Quercetin, a natural polyphenolic flavonoid, i
Externí odkaz:
https://doaj.org/article/98ef9c3e76304a92a4a0e9c96a529767
Autor:
Ludovica Lopresti, Nagaja Capitani, Vanessa Tatangelo, Carmela Tangredi, Gioia Boncompagni, Federica Frezzato, Andrea Visentin, Giuseppe Marotta, Sara Ciofini, Alessandro Gozzetti, Monica Bocchia, Livio Trentin, Cosima T. Baldari, Laura Patrussi
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Introduction: Escape from immunosurveillance is a hallmark of chronic lymphocytic leukemia (CLL) cells. In the protective niche of lymphoid organs, leukemic cells suppress the ability of T lymphocytes to form the immune synapse (IS), thereby hamperin
Externí odkaz:
https://doaj.org/article/e7e9e6a473054becbee4aeecfc465039
Akademický článek
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K zobrazení výsledku je třeba se přihlásit.
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Publikováno v:
Gynecological Endocrinology, Vol 39, Iss 1 (2023)
Context Substantial evidence suggests that ovarian oxidative stress can result in severe ovarian dysfunction.Objective The purpose of this article is to investigate the potential of SIRT6 in alleviating premature ovarian failure (POF) by inhibiting o
Externí odkaz:
https://doaj.org/article/629ef3b089e24628a1af68eddf9ba690
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 7, p 3656 (2024)
This review investigates the multifaceted role of the p66Shc adaptor protein and the gut microbiota in regulating mitochondrial function and oxidative stress, and their collective impact on the pathogenesis of chronic diseases. The study delves into
Externí odkaz:
https://doaj.org/article/bbafcec32a224b858acc61c78f0b1734
Autor:
Tao Jiang, Tao Qin, Peng Gao, Zhiwen Tao, Xiaowei Wang, Mengyuan Wu, Jun Gu, Bo Chu, Ziyang Zheng, Jiang Yi, Tao Xu, Yifan Huang, Hao Liu, Shujie Zhao, Yongxin Ren, Jian Chen, Guoyong Yin
Publikováno v:
Redox Biology, Vol 60, Iss , Pp 102615- (2023)
Disruption of the blood-spinal cord barrier (BSCB) leads to inflammatory cell infiltration and neural cell death, thus, contributing to poor functional recovery after spinal cord injury (SCI). Previous studies have suggested that Sirtuin 1 (SIRT1), a
Externí odkaz:
https://doaj.org/article/af2ff717d7f04f499bdad787eb5a9862