Zobrazeno 1 - 10
of 302
pro vyhledávání: '"P38 MAPK signaling pathway"'
Autor:
Zhenning Tang, Hanying Song, Shaojie Qin, Zengjian Tian, Chaolin Zhang, Yang Zhou, Ruizhi Cai, Yongzhao Zhu
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Breast cancer patients often have a poor prognosis largely due to lack of effective targeted therapy. It is now well established that monosaccharide enhances growth retardation and chemotherapy sensitivity in tumor cells. We investigated whe
Externí odkaz:
https://doaj.org/article/5399559644fe44d996c220a313970b70
Therapeutic potential of ASK1 activators in cancer treatment: Current insights and future directions
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 178, Iss , Pp 117214- (2024)
Apoptosis signal-regulated kinase 1 (ASK1) is a member of the mitogen-activated protein kinase kinase (MAP3K) family, whose activation and regulation are intricately associated with apoptosis. ASK1 is activated in response to oxidative stress, among
Externí odkaz:
https://doaj.org/article/008d9042ae1647d8b83f1564007d11b2
Autor:
Hai-Zhen Duan, Xin Zhou, Quan Hu, Meng-Long Liu, Shu-Hong Wang, Ji Zhang, Xu-Heng Jiang, Tian-Xi Zhang, An-Yong Yu
Publikováno v:
Chinese Journal of Traumatology, Vol 27, Iss 1, Pp 42-52 (2024)
Purpose: Mannitol is one of the first-line drugs for reducing cerebral edema through increasing the extracellular osmotic pressure. However, long-term administration of mannitol in the treatment of cerebral edema triggers damage to neurons and astroc
Externí odkaz:
https://doaj.org/article/64575b8847144fc8af256ded43126b30
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 18, Iss 1, Pp 1-9 (2023)
Abstract Objective The aim of this study was to investigate whether Osteonectin/Secreted protein acidic and rich in cysteine (ON/SPARC) had a two-way dose-dependent regulatory effect on osteoblast mineralization and its molecular mechanism. Methods I
Externí odkaz:
https://doaj.org/article/f5a11078a0dd4a2f9ec2ed45d14b37fe
Autor:
Fuxing Ge, Xiaoli Gao, Xiaochun Zhou, Junjun Li, Xiaojing Ma, Meiwen Huang, Sana Wuken, Pengfei Tu, Chao An, Xingyun Chai
Publikováno v:
Chinese Medicine, Vol 18, Iss 1, Pp 1-13 (2023)
Highlights The total extract of Corydalis hendersonii Hemsl. (CH) and the rich alkaloids fraction (RAF) of CH showed significant cardioprotective effect on mice following acute myocardial infarction. RAF improved cardiac function by inhibiting apopto
Externí odkaz:
https://doaj.org/article/ace5e92b5aba428cb8ae02e6a3fe0e8a
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2681 (2024)
Mouse embryonic stem cells (ESCs) and epiblast stem cells (EpiSCs) are derived from pre- and post-implantation embryos, representing the initial “naïve” and final “primed” states of pluripotency, respectively. In this study, novel reprogramm
Externí odkaz:
https://doaj.org/article/1a625105ceda4628bde3d61d51f74201
Publikováno v:
Virology Journal, Vol 19, Iss 1, Pp 1-17 (2022)
Abstract Background Bovine parainfluenza virus type 3 (BPIV3) infection often causes respiratory tissue damage and immunosuppression and further results in bovine respiratory disease complex (BRDC), one of the major diseases in dairy cattle, caused h
Externí odkaz:
https://doaj.org/article/450d391dccfa4e8487caa27ef23af796
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
BackgroundPeriodontitis is one of the most common oral diseases and has been shown to be a risk factor for systemic diseases. Our aim was to investigate the relationship between periodontitis and cognitive impairment and to explore the role of the P3
Externí odkaz:
https://doaj.org/article/c5f783b8f7604670a4f242baf53e1f9c
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 16, Iss 1, Pp 1-11 (2021)
Abstract Objective The present study aimed to determine the role of the discoidin domain receptor 2 (DDR2) in the osteonectin (ON) regulation of osteoblast mineralization through the activation of p38 mitogen-activated protein kinase (MAPK). Methods
Externí odkaz:
https://doaj.org/article/c02c3e6261414b0394c2d9016e080933
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundMonocyte chemoattractant protein-4 (MCP-4/CCL13) is a proinflammatory factor that is overexpressed in various malignant tumors and may play an important role in tumor progression and metastasis. However, its role and mechanism of action in
Externí odkaz:
https://doaj.org/article/dfd99cd560934267bf08bdde94b4c321