Zobrazeno 1 - 10
of 48
pro vyhledávání: '"P.W. Helleman"'
Autor:
E.I. Krajnc, P.W. Helleman, H.A.M.G. Vaessen, C.A. van der Heijden, J.G. Loeber, F.X.R. van Leeuwen, P.W. Wester
Publikováno v:
Food and Chemical Toxicology. 28:179-196
In a 106-wk toxicity and carcinogenicity study, groups of 60 male and 60 female weanling Wistar rats were fed 0, 0.5, or 50 mg bis(tri-n-butyltin)oxide (TBTO)/kg diet. In males, feed consumption was increased in all treated groups and increased water
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e77e47bf178f5f72e3e066a21e9bd6b4
https://doi.org/10.1016/0278-6915(90)90006-9
https://doi.org/10.1016/0278-6915(90)90006-9
Autor:
G.J.A. Speijers, E.C. Beuvery, C.A.v.d. Heijden, F.X.R. van Leeuwen, M.A.M. Krajnc-Franken, Joseph G. Vos, L.H.J.C. Danse, P.W. Helleman
Publikováno v:
Vaccine. 7:364-368
In order to assess the systemic toxicity of Zwittergent 3-14, a detergent used in the protein-detergent complex vaccines for its attractive immunogenic properties, a subacute toxicity study was performed. In this 4-week toxicity experiment five femal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::525ec6c2f6b19681c004206717fef0df
https://doi.org/10.1016/0264-410x(89)90203-x
https://doi.org/10.1016/0264-410x(89)90203-x
Autor:
H.G. Verschuuren, J.M. Berkvens, A.G. Rauws, Engelina M. den Tonkelaar, P.W. Helleman, P.L. Schuller, G.J. van Esch, R. Kroes
Publikováno v:
Toxicology. 6:107-123
Four groups, each of 25 male and 25 female weanling rats, were given dietary levels of 0, 0.1, 0.5 and 2.5 ppm MeHgCl for 2 years. Observations were made on behaviour, growth, food intake, haematology, serum enzymes, urinalysis, microsomal liver enzy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3722449b3485864901fc5e39b6ebbcdb
https://doi.org/10.1016/0300-483x(76)90012-3
https://doi.org/10.1016/0300-483x(76)90012-3
Autor:
J.M. Berkvens, H.G. Verschuure, G.J. van Esch, P.W. Helleman, P.L. Schuller, R. Kroes, Engelina M. den Tonkelaar, A.G. Rauws
Publikováno v:
Toxicology. 6(1)
In the range-finding test, 6 groups of 4 male and 4 female weanling rats were given dietary levels of 0, 0.1, 0.5, 2.5, 12.5 and 250 ppm methylmercury chloride (MeHgCl) for 2 weeks. Signs of central nervous system toxicity, weight los and high mortal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7390643d4eb5a0efdabbbf95e716fb3c
https://pubmed.ncbi.nlm.nih.gov/941167
https://pubmed.ncbi.nlm.nih.gov/941167
Publikováno v:
Toxicology. 5(3)
In a 90-day feeding study, 4 groups of 10 male and 10 female rats received in the diet 0, 200, 1000 and 5000 ppm 1-naphthaleneacetic acid (1-NAA). Growth and food intake was reduced significantly only in males on 5000 ppm. Haematological examination
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca43126c1ad2ca199eb3fc4b03f2273
https://pubmed.ncbi.nlm.nih.gov/1265775
https://pubmed.ncbi.nlm.nih.gov/1265775
Autor:
G.J. van Esch, H.G. Verschuuren, Engelina M. den Tonkelaar, P.W. Helleman, J.M. Berkvens, R. Kroes
Publikováno v:
Toxicology. 4(1)
Rats received 0, 200, 1000 and 5000 ppm metaldehyde in the diet for 2 years. Reproduction studies over three generations using the same dietary levels were carried out. In the third litter of each generation attention was paid to possible embryotoxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b102910caabea6fbf12ce0bea70a57d2
https://pubmed.ncbi.nlm.nih.gov/1129810
https://pubmed.ncbi.nlm.nih.gov/1129810
Autor:
Engelina M. Den Tonkeaar, P.W. Helleman, A.G. Rauws, P.L. Schuller, R. Kroes, H.G. Verschuuren, J.M. Berkvens, G.J. van Esch
Publikováno v:
Toxicology. 6(1)
A reporduction study over 3 generation of rats was carried out in which groups of 20 female and 10 male rats received in the diet 0, 0.1, 0.5 and 2.5 ppm MeHgCl. The parameters studied included growth, food intake, haematology, serum and urinalysis,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2abdd376d65d5eb7f5d6fb98b095d123
https://pubmed.ncbi.nlm.nih.gov/941169
https://pubmed.ncbi.nlm.nih.gov/941169
Publikováno v:
Toxicology and applied pharmacology. 16(2)
In two experiments an immunosuppressive effect of triphenyltin acetate (TPTA) in female guinea pigs was detected with immunochemic, serologic, histologic, and fluorescent antibody techniques. In the first experiment the animals were given 0 or 15 ppm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c132f9ffe242c41271a51b82400c071d
https://pubmed.ncbi.nlm.nih.gov/4907944
https://pubmed.ncbi.nlm.nih.gov/4907944
Publikováno v:
Biochimica et Biophysica Acta (BBA)-Enzymology, 185(1), 63. Elsevier
1. 1. Glutathione reductase (NAD(P)H: oxidized glutathione oxidoreductase, EC 1.6.4.2) from the erythrocytes of a patient with a decreased activity of the enzyme was purified 10 000 times (specific activity, 20 μmoles NADPH oxidized per min per mg p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ad7909a3f8954de42fcffc7ff23f022
https://pubmed.ncbi.nlm.nih.gov/5796112
https://pubmed.ncbi.nlm.nih.gov/5796112
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