Zobrazeno 1 - 10
of 55
pro vyhledávání: '"P.W. Faber"'
Autor:
Conny C. Ehren-van Eekelen, Jan Trapman, P.W. Faber, Kitty B.J.M. Cleutjens, Hetty A. G. M. van der Korput, Henri C.J. van Rooij
Publikováno v:
Molecular Endocrinology. 11:148-161
Prostate-specific antigen (PSA) is expressed at a high level in the luminal epithelial cells of the prostate and is absent or expressed at very low levels in other tissues. PSA expression can be regulated by androgens. Previously, two functional andr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fd66af41d3056044abfc95149712833
https://doi.org/10.1210/mend.11.2.9883
https://doi.org/10.1210/mend.11.2.9883
Autor:
Jan Trapman, Johannes C. Romijn, Nicole S. Verkaik, P.W. Faber, Fritz H. Schröder, Hendrikus J. Dubbink
Publikováno v:
Biochemical Journal. 315:901-908
Transglutaminases (TGases) are calcium-dependent enzymes catalysing the post-translational cross-linking of proteins. In the prostate at least two TGases are present, the ubiquitously expressed tissue-type TGase (TGC), and a prostate-restricted TGase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30f720e0714734f4a2f7c75ec87e3fdb
https://doi.org/10.1042/bj3150901
https://doi.org/10.1042/bj3150901
Publikováno v:
Biochemical and Biophysical Research Communications. 220:858-863
Keratinocyte Growth Factor (KGF/FGF7) is a candidate andromedin in normal embryonic development of male accessory sex glands, such as the prostate and seminal vesicles. The expression of KGF mRNA and protein is androgen-responsive. To elucidate the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa02360de2e274e1a48651bae781e390
https://doi.org/10.1006/bbrc.1996.0497
https://doi.org/10.1006/bbrc.1996.0497
Publikováno v:
Journal of Biological Chemistry. 268:9296-9301
In this study, the minimal promoter requirements of the TATA-less human androgen receptor (hAR) gene promoter are described. The hAR promoter is characterized by a short GC-box (-59/-32) and a long homopurine stretch (-117/-60). Two major transcripti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8cee379640020fad215e9a403dba6b99
https://doi.org/10.1016/s0021-9258(18)98349-3
https://doi.org/10.1016/s0021-9258(18)98349-3
Publikováno v:
Biochemical Journal. 278:269-278
Screening a mouse genomic DNA library with human androgen-receptor (hAR) cDNA probes resulted in the isolation and characterization of eight genomic fragments that contain the eight exons of the mouse androgen-receptor (mAR) gene. On the basis of sim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70f9a3389a6479609ee2287d4692d147
https://doi.org/10.1042/bj2780269
https://doi.org/10.1042/bj2780269
Autor:
J. A. Grootegoed, Albert O. Brinkmann, H. C. J. Van Rooij, Jan Trapman, H. A. G. M. Van Der Korput, Willy M. Baarends, P.W. Faber
Publikováno v:
Journal of Biological Chemistry. 266:10743-10749
A full length human androgen receptor (hAR) cDNA was constructed from cDNA and genomic clones. Structurally the 10.6-kilobase (kb) hAR cDNA consists of a long 5'-untranslated region (5'-UTR, 1.1 kb), a previously described open reading frame (ORF, 2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::527689fccac2c069c499cbb3d4782d93
https://doi.org/10.1016/s0021-9258(18)99080-0
https://doi.org/10.1016/s0021-9258(18)99080-0
Autor:
Axel P. N. Themmen, P.W. Faber, Dies Meijer, Jan Trapman, P. Mackenbach, Albert O. Brinkmann, Leen J. Blok, J. Anton Grootegoed, Willy M. Baarends
Publikováno v:
Molecular and Cellular Endocrinology. 74:75-84
The androgen receptor (AR) is activated upon binding of testosterone or dihydrotestosterone and exerts regulatory effects on gene expression in androgen target cells. To study transcriptional regulation of the rat AR gene itself, the 5' genomic regio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f93f50cb545890995bfbd702a00d909
https://doi.org/10.1016/0303-7207(90)90207-o
https://doi.org/10.1016/0303-7207(90)90207-o
Autor:
Jan Trapman, Paul Doesburg, and Albert O. Brinkmann, Cor A. Berrevoets, Eppo Mulder, P.W. Faber, Karine Steketee, Cor W. Kuil
Publikováno v:
Biochemistry, 36, 1052-1064. American Chemical Society
The ligand binding domain (LBD) and the amino-terminal, transactivation domain (TAD) of the androgen receptor (AR) were separately linked to the GAL4 DNA binding domain (DBD) and to the GAL4(TAD). Resulting constructs were tested in the yeast two-hyb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1469305a299d1fefc65d82e9d00632be
https://pubmed.ncbi.nlm.nih.gov/9033395
https://pubmed.ncbi.nlm.nih.gov/9033395
Publikováno v:
Genomics. 24(1)
The interferon-α (IFN-α) regulated mouse Ifi54/Ifi56 gene family, which is composed of at least four members (Ifi54, Ifi56, Ifi56-ps1 , and Ifi56-ps2), was isolated and characterized. In addition, the chromosomal localization of the four genes was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72a1fefb5b3393a300d9328b6e520d0d
https://pubmed.ncbi.nlm.nih.gov/7896268
https://pubmed.ncbi.nlm.nih.gov/7896268
Autor:
G.J. van Steenbrugge, Jan Trapman, J A Ruizeveld de Winter, T.H. Van Der Kwast, W.M. Van Weerden, P.W. Faber, Albert O. Brinkmann
Publikováno v:
Endocrinology. 131(6)
In vivo effects of androgen withdrawal and substitution on human androgen receptor (hAR) expression were evaluated in the androgen-dependent human prostatic carcinoma tumor line PC-82. By application of several antibodies reactive with different epit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80748f57cb29b7535fad628f6ef1c2b7
https://pubmed.ncbi.nlm.nih.gov/1446639
https://pubmed.ncbi.nlm.nih.gov/1446639