Zobrazeno 1 - 10
of 43
pro vyhledávání: '"P.V. Newcomb"'
Autor:
Derek Alderson, Roger Feakins, P.B. Savage, Jyoti Gupta, Jeffrey M P Holly, Moganaden Moorghen, Andrew Hollowood, P.V. Newcomb, Zun-Wu Zhang
Publikováno v:
Cancer Causes & Control. 15:211-218
IGF family proteins play a pivotal role in regulating cell growth and apoptosis in normal and tumour tissues. IGFBP-3 is the major binding protein of IGFs and modulates the bioactivity of IGFs. To examine the role of IGFBP-3 in gastric cancer, an IGF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9867c5672bfa96c930a363bfac5a6c7
https://doi.org/10.1023/b:caco.0000019510.96285.e9
https://doi.org/10.1023/b:caco.0000019510.96285.e9
Autor:
Zun-Wu Zhang, Derek Alderson, Jeffrey M P Holly, Roger Feakins, Michael J.G. Farthing, Nicola J. Laurence, Andrew Hollowood, Jyoti Gupta, P.V. Newcomb, Moganaden Moorghen
Publikováno v:
Clinical Cancer Research. 10:131-135
Purpose: A common polymorphism of the tumor suppressor gene TP53 at codon 72 has been associated with human cancer susceptibility. The prognostic role of the polymorphism was assessed in 102 patients with advanced gastric adenocarcinoma. Experimental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85e4cbdade89ee1a70716e61eb8896f6
https://doi.org/10.1158/1078-0432.ccr-0853-3
https://doi.org/10.1158/1078-0432.ccr-0853-3
Publikováno v:
International Journal of Cancer. 88:448-453
Variability in response to chemotherapy is poorly understood. Paclitaxel-induced apoptosis was assessed in human Hs578T breast cancer cells, using the MTT assay, cell counting, morphological features and flow cytometry. Pre-dosing cells with non-glyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d170cca419d440d69931cd63ac9d0dde
https://doi.org/10.1002/1097-0215(20001101)88:3<448::aid-ijc18>3.0.co
https://doi.org/10.1002/1097-0215(20001101)88:3<448::aid-ijc18>3.0.co
Publikováno v:
Journal of Cellular Biochemistry. 75:652-664
We have demonstrated previously that insulin-like growth factor binding protein (IGFBP)-3 alone has little growth inhibitory effect on Hs578T human breast cancer cells, but that it can dramatically accentuate the apoptotic response to the physiologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50361f89e5ea784279506578ecc4c19b
https://doi.org/10.1002/(sici)1097-4644(19991215)75:4<652::aid-jcb11>3.0.co
https://doi.org/10.1002/(sici)1097-4644(19991215)75:4<652::aid-jcb11>3.0.co
Publikováno v:
British Journal of Cancer
Cell counting, cell cycle analysis and Western immunoblotting were used to examine the effects of non-apoptotic doses of a ceramide analogue, C2, and a synthetic arginine–glycine–aspartic acid (RGD)-containing peptide, RGD, in MCF-7 and T47D cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca52dc00d03f6fca1583e8a070f5c43
http://europepmc.org/articles/PMC2362662
http://europepmc.org/articles/PMC2362662
Publikováno v:
European Journal of Surgical Oncology (EJSO). 23:513-517
Human papillomavirus (HPV) has previously been identified in up to 67% of squamous cell carcinomas of the oesophagus. In particular, HPV types of 16 and 18 are believed to play an important role in neoplastic transformation, by means of their oncopro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cc55dff3ea631053326638357856bd9
https://doi.org/10.1016/s0748-7983(97)92981-4
https://doi.org/10.1016/s0748-7983(97)92981-4
Publikováno v:
European Journal of Surgical Oncology (EJSO). 23:24-29
Overexpression of the tumour suppressor gene product p53 is common in oesophageal adenocarcinoma. This may be due to gene mutation, but overexpression can also result from complexing between viral proteins and p53; a number of viruses are causally li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b30a7701b264f20ed65471ac39d0af84
https://doi.org/10.1016/s0748-7983(97)80138-2
https://doi.org/10.1016/s0748-7983(97)80138-2
Publikováno v:
Journal of Clinical Pathology. 48:129-132
AIMS--To investigate overexpression of the oncoprotein c-erbB-2 in the dysplasia/carcinoma sequence of Barrett's columnar-lined oesophagus (CLO). METHODS--Immunohistochemical staining was performed using the monoclonal antibody NCL-CB-11 on formalin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f4afdcf06a81bf2b607431c0cb68631
https://doi.org/10.1136/jcp.48.2.129
https://doi.org/10.1136/jcp.48.2.129
Publikováno v:
Gut. 35:764-768
Adenocarcinoma arising in Barrett's oesophagus is often preceded by mucosal dysplasia, but little is currently known about the aetiology or natural history of this dysplasia/carcinoma sequence. To investigate the participation of the tumour suppresso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8805c6dcb3ea76c2f05129aafd10eaf9
https://doi.org/10.1136/gut.35.6.764
https://doi.org/10.1136/gut.35.6.764
Autor:
P.V. Newcomb, Jyoti Gupta, Alan Storey, Derek Alderson, Zun-Wu Zhang, Michael J.G. Farthing, Moganaden, Andrew Hollowood, Jeffrey M P Holly, Roger Feakins
Publikováno v:
Digestive diseases and sciences. 49(2)
Gastric ulcer is positively, and duodenal ulcer negatively, associated with the risk of gastric cancer. The relationship between a common p53 polymorphism at codon 72 and gastric cancer risk in patients with gastric and duodenal ulcer was examined in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2459bd09c5c0fc26c9b8e668355666c8
https://pubmed.ncbi.nlm.nih.gov/15104366
https://pubmed.ncbi.nlm.nih.gov/15104366