Influence of oxygen supply on liver condition and elimination of dimethylacetamide in the isolated perfused rat liver

Autor: N. G. M. Palmen, Paul J. A. Borm, Chris T. Evelo, P.Th. Henderson

Publikováno v: Europe PubMed Central

The effects were studied of improved oxygen supply on the integrity and metabolic activity towards dimethylacetamide of the isolated perfused rat liver. Improvement of oxygen supply by increased medium oxygenation or addition of chemical oxygen carri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfe74db6df6c8031317d1becc700056d
https://doi.org/10.1016/0887-2333(92)90026-n

Influence of glutathione on the formation of cysteine alkylation products in human hemoglobin

Autor: Chris T. Evelo, P.Th. Henderson

Publikováno v: Toxicology. 52:177-186

Human blood samples were treated in vitro with iodoacetamide. At low concentrations - less than 1 mM - only a low fraction of the beta 93 cysteine in hemoglobin was alkylated, whereas the alkylating reaction with glutathione was extensive. At higher

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b44f62ff559f222533ff1fd25d6223c
https://doi.org/10.1016/0300-483x(88)90203-x

Metabolic activation of N-acetylbenzidine and N, N′-diacetylbenzidine to mutagens, using isolated hepatocytes and the 9000 × g liver supernatant from rat, hamster and guinea pig

Autor: P.Th. Henderson, R.P. Bos, P.J.L. van Gemert, Hennie M.J. Roelofs, J.M. Neis

Publikováno v: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 151:195-200

The metabolic activation of MABZ and DABZ, forming products mutagenic towards Salmonella typhimurium TA1538, was studied with isolated hepatocytes from rat, hamster and guinea pig and the S9 fraction (9000 × g supernatant) prepared from these hepato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5688565fc894ccf63db0eb3654200734
https://doi.org/10.1016/0027-5107(85)90071-5

Dutch Pharmacological Meeting 1984

Autor: J. Mooy, Margot J. H. de Reus, G. R. Mohn, Ch. M. Leijdekkers, J. Van Harten, H. J. M. Salden, J. G. Loeber, M. Raghoebar, R. J. M. ten Berge, Joop S. de Graaf, W. de Jong, E. M. van der Beek, C. A. M. Van Ginneken, P. W. Wester, J. B. M. van Driel, Peter M. Edelbroek, Hans Rollema, C. A. J. M. Vulders, D. J. Touw, J. J. Grote, Pramod R. Saxena, E. I. Krajnc, Frans P. Nijkamp, J. Kreukniet, Frederik A. de Wolff, H. Burbach, F. C. Hillen, W. Kruizinga, F. W. J. Gribnau, P. H. Hofman, M. J. A. M. Franssen, K. H. Rahn, Frans G. M. Russel, Hans J. Steenbergen, E. Laban, D.J. de Wildt, H. Wollersheim, Npe Vermeulen, H. M. E. Scheres, M. Van Der Graaff, L. R. Remeyer, E. Ronald de Kloet, M. C. M. Rijk, H. J. H. Salden, F. J. Jongeneelen, Theo Mulder, H. E. Sluiter, T. Bultsma, A. B. M. Klaassen, M. v. Baak, J. A. H. Raaijmakers, A. J. van Rozen, J. F. M. Nouws, R. A. P. Koene, N. Verbeke, H. L. G. H. Tiemessen, B. J. L. Kothuis, Cor J. de Vos, R.P. Bos, J. G. P. Peters, Frans W. H. M. Merkus, C. E. M. Zoetemelk, Mjmc Thoolen, M. R. Linschoten, P. T. A. Schellekens, W. Buijs, Th. Thien, H. Th. M. Folgering, L. Conings, D. K. F. Meijer, J. J. Cox van Put, J. De Gier, Ferdi Engels, W. Kateman, P. Lomax, F. Th. M. Huysmans, F. X. R. van Leeuwen, C. J. Van Boxtel, Y. Tan, M. J. Krielaart, G. A. Charbon, J. G. Vos, B. J. 't Hart, J. Jelinek, P. van Heuven-Nolsen, W. J. Wijnands, A. de Jonge, G. R. Bolt, U. R. Tjaden, K. U. Leuven, Durk Oijkstra, Lambert H.M. Janssen, C. M. M. Veldhoven, H. M. N. Nievelstein, E. J. AriËns, H. M. J. Roelofs, A. van 't Laar, L. H. van den Berg, H. N. Doods, F. Corstens, M. v. Hengstum, O. Driessen, R. Groothedde, G. B. van der Voet, W. Kuijpers, A. de Klerk, E. Schönbaum, D. D. Breimer, B. van Ommen, C. A. van der Heijden, M. v. Hooff, E. A. De Bruijn, Hendrik Timmerman, L. C. M. Baars, P van Brummelen, C. T. A. Evelo, A. J. Beld, H. H. W. Thljssen, G. Aué, R. van Doorn, H. A. M. G. Vaessen, J. Fennis, Theo B.A. Mulder, W. v. d. Broek, G. K. Terpstra, A. T. van Oosterom, Cor J. Grol, R. A. Lefebvre, P. A. Van Zwieten, A. C. Wouterse, Rob B. M. Anzion, J. F. Rodrigues De Miranda, C. Neef, R. S. Oosting, A. Van Der Gen, C. H. Kleinbloesem, Marian W. Tijhuis, Yechiel A. Hekster, H. A. J. Struyker Boudier, C. L. A. van Herwaarden, Bob Wilffert, Dora Mastebroex, E. A. van der Velde, A. S. P. M. Breed, H. L. M. Siero, Gerard van Aalst, J. L. G. Theuws, F. A. De Wolff, J. Rozing, E. I. Krajc, R. H. B. Meyboom, M. A. M. ten Broeke, J. Festen, P.J.L. van Gemert, A. P. I. Jzerman, Hans Wynberg, Alan Horn, H. J. E. Reeuwijk, B. O Osterhuis, R. Dorlas, P. A. M. Peeters, J. Willemsen, L. M. de Brauw, Jan B. de Vries, L. B. A. van de Putte, Alan S. Horn, J. H. Canton, H. J. E. M. Reeuwijk, M. Schols, J. A. M. Raaijmakers, Marcus Bogaert, J. van Noordwijk, Durk Dijkstra, P.Th. Henderson, Peter P. Koopmans, J. W. J. Lammers, T. B. Vree, C. J. H. van de Velde, C. J. Van Koppen, Bernard Hazelhoff, Jaap Wilting, H. M. Pinedo, W. Kuypers, C. M. Ruland, H. A. J. Struyker-Boudier, J. M. Neis, P. B. M. W. M. Timmermans, H. O. Kalkman, P. R. M. Kerklaan, P. A. F. Jansen, J. Peter, J. H. Koeman, H. J. Huidekoper, Mj Mathy, A.F. De Schaepdryver, R.A.M. van der Hoeven, Jos F.M. Smits, Tjeerd van den Berg, E. H. den Tonkelaar, J. W. M. Lenders, P. Sandor, C. A. v. d. Heijden, G. A. Wassink, O. Castelein, P. H. Th. J. Slee

Publikováno v: Pharmaceutisch Weekblad. 6:163-184

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0feb23f7a988a0d11f3171454f7aae1
https://doi.org/10.1007/bf01954045

Mutagenicity towards Salmonella typhimurium of some known genotoxic agents, activated by isolated hepatocytes of monkey (Macaca fascicularis)

Autor: P.Th. Henderson, P.J.L. van Gemert, Hennie M.J. Roelofs, J.M. Neis

Publikováno v: Mutation Research/Environmental Mutagenesis and Related Subjects. 164:139-143

This paper describes some striking differences between isolated human and monkey hepatocytes in their capacity to activate some known genotoxic agents into products mutagenic towards Salmonella typhimurium . Isolated monkey hepatocytes, in contrast t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::08c0b4f6aa7b4d121d8cf33efddbedee
https://doi.org/10.1016/0165-1161(86)90005-1