Zobrazeno 1 - 10
of 35
pro vyhledávání: '"P.T.M. Kok"'
Autor:
Leo Koenderman, T. Van Der Bruggen, Michela Blom, J. A. M. Raaijmakers, P.T.M. Kok, Jan Willem J. Lammers, Arthur J. Verhoeven
Publikováno v:
Scopus-Elsevier
We report that a transient incubation of human eosinophils with the protein kinase C (PKG) inhibitor CGP39-360 (staurosporine) or the more PKC-specific inhibitors CGP41-251 and CGP44-800 prior to activation of the respiratory burst with opsonized par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d20d82006b3128c4eb9d1dc97b4a21a8
https://doi.org/10.1002/jlb.54.6.552
https://doi.org/10.1002/jlb.54.6.552
Autor:
P.T.M. Kok, R. G. C. Kessels, T. Van Der Bruggen, Leo Koenderman, J. A. M. Raaijmakers, Arthur J. Verhoeven, Jan Willem J. Lammers
Publikováno v:
Scopus-Elsevier
We report that pretreatment of human eosinophils with GM-CSF, IL-3, or IL-5 enhanced the respiratory burst induced by opsonized particles. In order to gain more insight into the intracellular mechanism(s) involved in cytokine priming, the role of [Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eba90e4bd6fd4a26af4d23dd08bfaa5f
https://doi.org/10.1002/jlb.53.4.347
https://doi.org/10.1002/jlb.53.4.347
Publikováno v:
Prostaglandins, Leukotrienes and Essential Fatty Acids. 44:11-17
Numbers of circulating basophils are increased in asthmatic subjects, compared to normal subjects. Basophil enriched cell preparations from normal and asthmatic subjects were challenged in vitro with the calcium ionophore A23187, anti-IgE, or opsoniz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::292ef6dfadbb1f18bc778c8dcfd864bb
https://doi.org/10.1016/0952-3278(91)90138-u
https://doi.org/10.1016/0952-3278(91)90138-u
Publikováno v:
British Journal of Pharmacology. 99:798-802
1. Neutrophils and eosinophils infiltrate the airways in association with the allergen-induced late phase asthmatic reaction. Mobilization of these cells takes place via lipid-like and protein-like chemotactic factors. In this study platelet-activati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4afd5e24f35f2bcafb98afd69cd6b786
https://doi.org/10.1111/j.1476-5381.1990.tb13009.x
https://doi.org/10.1111/j.1476-5381.1990.tb13009.x
Publikováno v:
British Journal of Pharmacology. 97:1251-1257
1. Inflammatory cells such as eosinophils and neutrophils are thought to contribute actively to the pathogenesis of asthma since they infiltrate into the lung tissue. These cells are mobilized by lipid-like and protein-like chemotactic factors. As il
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc9c7271bceeaa39340eb6dd8d01d51
https://doi.org/10.1111/j.1476-5381.1989.tb12586.x
https://doi.org/10.1111/j.1476-5381.1989.tb12586.x
Publikováno v:
British Journal of Pharmacology. 96:631-636
1. Inflammatory cells such as eosinophils and neutrophils are thought to contribute actively to the pathogenesis of asthma by the release of bronchoconstrictor mediators including leukotrienes. Previous studies have revealed the almost exclusive synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcd3e0079665b2cdeeb1caef53a98d26
https://doi.org/10.1111/j.1476-5381.1989.tb11862.x
https://doi.org/10.1111/j.1476-5381.1989.tb11862.x
Publikováno v:
Pharmacological Research Communications. 18:61-69
Human eosinophils are capable of synthesizing almost exclusively the strongly spasmogenic compound LTC4 when stimulated with either the calcium ionophore A 23187 or opsonized zymosan (OZ). Although PAF-acether in concentrations ranging from 10 nM to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64b76d554afdee79b2c5496c5cbef70b
https://doi.org/10.1016/0031-6989(86)90039-1
https://doi.org/10.1016/0031-6989(86)90039-1
Publikováno v:
Drugs. 37:9-18
Inflammatory cells, such as neutrophils and eosinophils, are thought to actively contribute to the pathogenesis of asthma since they infiltrate into the lung tissue and may be activated locally to release bronchoconstrictor mediators. In this study w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a58f76c483fea67a541ef7e99ac2387c
https://doi.org/10.2165/00003495-198900371-00004
https://doi.org/10.2165/00003495-198900371-00004
Autor:
Gerrit A. Veldink, Leo Koenderman, Maartje L. Hamelink, G. M. Kijne, P.T.M. Kok, Pieter L.B. Bruynzeel, Jan Verhagen
Publikováno v:
Agents and Actions. 26:96-98
Addition of arachidonic acid (50 microM) to purified human eosinophils leads to the formation of considerable amounts of LTC4 [11.3 +/- 1.3) x 10(6) molecules/cell, mean +/- SEM, n = 10), 15-HETE [412 +/- 142) x 10(6) molecules/cell, mean +/- SEM, n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0421bde82815ae9a0076ef1946fc1c05
https://doi.org/10.1007/bf02126571
https://doi.org/10.1007/bf02126571
Publikováno v:
Scopus-Elsevier
A simple and improved procedure is described for the isolation of human eosinophils from normal individuals with about 2% eosinophils in their peripheral blood. This method comprises a preincubation of a mixed granulocyte preparation with 10 nM fMLP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d448d12bf667540a2903d8b09573dd
https://pubmed.ncbi.nlm.nih.gov/3404069
https://pubmed.ncbi.nlm.nih.gov/3404069