Zobrazeno 1 - 10
of 134
pro vyhledávání: '"P.R.J. Gangadharam"'
Publikováno v:
Journal of Antimicrobial Chemotherapy. 43:615-623
Riminophenazines were specifically developed as drugs active against Mycobacterium tuberculosis but extensive research over several decades has shown that these compounds are also active against many other mycobacterial infections, particularly those
Autor:
Charles M. Lyons, Donald L. Wise, P.R.J. Gangadharam, Debra J. Trantolo, Yung Yueh Hsu, Joseph D. Gresser
Publikováno v:
Journal of Biomedical Materials Research. 35:107-116
The purpose of this study was to compare the effect of polymer foam morphology and density prior to compaction on the kinetics of isoniazid (INH) release from the final high-density extruded matrices. The feasibility of preparing low density foams of
Publikováno v:
Microbial Pathogenesis. 21:97-109
Mycobacterium avium complex (MAC) strains are known to exhibit variation in colony morphology. In addition to the smooth transparent (ST), smooth opaque (SO) and rough opaque (RO), which are the most common morphological forms, intermediate (IM) and
Publikováno v:
Tubercle and Lung Disease. 77:154-159
Objective: To investigate the chemotherapeutic activity of benzoxazinorifamycin, KRM-1648, in comparison with rifabutin (RFB) and rifampin (RIF) against experimental tuberculosis. Design: C57BL/6 mice were infected with 10 5 –10 6 colony forming un
Publikováno v:
Antimicrobial Agents and Chemotherapy. 39:2692-2695
Antituberculosis activity of clarithromycin (CLA), a macrolide antibiotic, was investigated in vitro, in macrophages, and in C57BL/6 mice, CLA showed high in vitro MICs (4 to > 16 micrograms/ml) for several strains of Mycobacterium tuberculosis and c
Autor:
P.R.J. Gangadharam
Publikováno v:
Antimicrobial Agents and Chemotherapy. 39:1647-1654
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 151:1083-1086
Clofazimine (CFM), a riminophenazine drug, is primarily used in therapy for leprosy and Mycobacterium avium infections. With an objective of identifying drugs active against Mycobacterium tuberculosis, including those with multi-drug resistance, we i
Publikováno v:
Antimicrobial Agents and Chemotherapy. 39:725-730
Mycobacterium avium complex (MAC) causes serious opportunistic infections in AIDS patients. Previous studies with MAC-infected beige mice have indicated that weekly administration of liposome-encapsulated streptomycin can reduce significantly the CFU
Autor:
Yung-Yueh Hsu, Donald L. Wise, Joseph D. Gresser, Charles M. Lyons, Debra J. Trantolo, P.R.J. Gangadharam
Publikováno v:
Journal of Controlled Release. 31:223-228
In vitro release kinetics of isoniazid (INH) from a biodegradable polymeric matrix has been investigated for systems prepared under varying fabrication conditions. Matrices were prepared either by evaporation of co-solutions followed by extrusion und
Publikováno v:
Tubercle and Lung Disease. 75:361-365
Setting: Poor patient compliance is the serious limiting factor in the chemotherapy of tuberculosis. Objective: To solve this problem we have been developing depot-drug delivery of antimycobacterial drugs. Earlier studies with mice using isoniazid in