Zobrazeno 1 - 10
of 258
pro vyhledávání: '"P.P.A. Humphrey"'
Publikováno v:
Drug Development Research. 53:60-65
The biophysical and functional properties of the human P2X 7 receptor, expressed recombinantly in HEK-293 cells or natively in THP-1 pro-monocytic cells, were investigated in the context of pore dilation and externalisation of mature interleukin 1 β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f9bd163d283881b44e12f423ce06a57
https://doi.org/10.1002/ddr.1171
https://doi.org/10.1002/ddr.1171
Publikováno v:
Alimentary Pharmacology & Therapeutics. 13:31-38
There is evidence from studies, in both animals and humans, that 5-HT3 receptor blockade has potential value in the treatment of irritable bowel syndrome, particularly in those patients with diarrhoea-predominant bowel habits. New findings suggest th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a5002065f81d631950541d4b1834ca7
https://doi.org/10.1046/j.1365-2036.1999.00003.x-i2
https://doi.org/10.1046/j.1365-2036.1999.00003.x-i2
Autor:
P.P.A. Humphrey, M.J. Sheehan, Julian Millar, D.R. Bull, Peter Palij, Jonathan A. Stamford, Zygmunt L. Kruk
Publikováno v:
Journal of Neuroscience Methods. 32:37-44
Fast cyclic voltammetry at a carbon fibre microelectrode was used to monitor the time course of dopamine overflow in slices of rat corpus striatum incubated in a brain slice chamber. Dopamine release occurred in response to electrical stimulation. El
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c91a103f808cd9d2ac5274310ea4662a
https://doi.org/10.1016/0165-0270(90)90069-r
https://doi.org/10.1016/0165-0270(90)90069-r
Publikováno v:
Neuroscience. 90(3)
Somatostatin is a neuromodulator in the mammalian CNS. To date, genes for at least five different somatotrophin release inhibiting factor receptors, termed sst1-sst5, have been cloned. The rat sst2 receptor exists in two splice variants, sst(alpha)a)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20d4f0551aab5f77c7b1ae513c99e554
https://pubmed.ncbi.nlm.nih.gov/10218786
https://pubmed.ncbi.nlm.nih.gov/10218786
Autor:
P.P.A. Humphrey, Jonathan A. Stamford, Julian Millar, M.J. Sheehan, Zygmunt L. Kruk, D.R. Bull, Peter Palij
Publikováno v:
Brain Research. 509:172-174
Dopamine release was evoked by single electrical pulses in slices of rat corpus striatum, and measured by fast cyclic voltammetry in real time. The magnitude of the release varied in the expected way to agents which modify dopamine storage, release a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec3010a8f826a83ac534975b5f5fc4a
https://doi.org/10.1016/0006-8993(90)90329-a
https://doi.org/10.1016/0006-8993(90)90329-a
Autor:
Alan W. Cuthbert, M. E. Hickman, Mathew J. Evans, William H. Colledge, P.W. Seale, P.P.A. Humphrey, Rosemary Ratcliff, L J MacVinish
Publikováno v:
Scopus-Elsevier
1. Guanylin, a 15 amino acid endogenous gut peptide, increased the short circuit current (SCC) in the epithelium of the mouse colon, but only when applied to the apical and not the basolateral surface. 2. By use of selective blockers of epithelial io
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea3de09782293fe73a562c04d01a83e
https://pubmed.ncbi.nlm.nih.gov/7518307
https://pubmed.ncbi.nlm.nih.gov/7518307
Autor:
P.P.A. Humphrey
Publikováno v:
Alimentary Pharmacology & Therapeutics. 13:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e41d9c96db330a740ff4466f00f9c39b
https://doi.org/10.1046/j.1365-2036.1999.00012.x
https://doi.org/10.1046/j.1365-2036.1999.00012.x
Publikováno v:
European Journal of Pharmacology. 183:1275-1276
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfa7cf7ff8d3f9a6972dc2bfd505044b
https://doi.org/10.1016/0014-2999(90)94382-8
https://doi.org/10.1016/0014-2999(90)94382-8
Autor:
P.P.A. Humphrey
Publikováno v:
Journal of Molecular and Cellular Cardiology. 22:S136
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8176b808bb63b39b461fa9a8b2de6cfd
https://doi.org/10.1016/0022-2828(90)91913-r
https://doi.org/10.1016/0022-2828(90)91913-r
Autor:
P.P.A. Humphrey
Publikováno v:
British journal of pharmacology. 54(3)
1 The water content and mannitol space of rat diaphragms which were perfused through the inferior vena cava was increased compared with immersed diaphragms. The potassium content of both preparations, when expressed in terms of dry weight, was mainta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::793253207479df726b59c81eb37d37e4
https://pubmed.ncbi.nlm.nih.gov/1164594
https://pubmed.ncbi.nlm.nih.gov/1164594