Zobrazeno 1 - 10
of 41
pro vyhledávání: '"P.P. Chamberlain"'
Autor:
P.P. Chamberlain, Steven A. Short, Joseph H. Chan, C.E. Nichols, Jingshan Ren, Kurt Weaver, David K. Stammers, Jörg-Peter Kleim
The selection of drug resistant viruses is a major problem in efforts to combat HIV and AIDS, hence, new compounds are required. We report crystal structures of wild-type and mutant HIV-1 RT with bound non-nucleoside (NNRTI) GW420867X, aimed at inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f5aa2452484a62bd3c23c20596e0d14
https://doi.org/10.1021/jm061117m
https://doi.org/10.1021/jm061117m
Autor:
Kurt Weaver, Jingshan Ren, L R Boone, R G Ferris, A Freeman, Steven A. Short, Anna Stamp, Richard J. Hazen, K.R Romines, C W Andrews Iii, P.P. Chamberlain, David K. Stammers, Joseph H. Chan
Publikováno v:
Journal of Medicinal Chemistry. 51:5000-5008
Owing to the emergence of resistant virus, next generation non-nucleoside HIV reverse transcriptase inhibitors (NNRTIs) with improved drug resistance profiles have been developed to treat HIV infection. Crystal structures of HIV-1 RT complexed with b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::832c8ffe10f26487effda5730a48ae45
https://doi.org/10.1021/jm8004493
https://doi.org/10.1021/jm8004493
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
David I. Stuart, P.P. Chamberlain, Jingshan Ren, Louise E. Bird, David K. Stammers, Guillaume Stewart-Jones
Publikováno v:
Proceedings of the National Academy of Sciences. 99:14410-14415
The HIV-2 serotype of HIV is a cause of disease in parts of the West African population, and there is evidence for its spread to Europe and Asia. HIV-2 reverse transcriptase (RT) demonstrates an intrinsic resistance to non-nucleoside RT inhibitors (N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::363a0d6da004e7c3ae563352c290410d
https://doi.org/10.1073/pnas.222366699
https://doi.org/10.1073/pnas.222366699
Autor:
Jingshan Ren, B. A. Larder, Johan Lennerstrand, P.P. Chamberlain, C.E. Nichols, L. Douglas, David K. Stammers, David I. Stuart
Publikováno v:
Journal of Virology. 76:10015-10019
Six structures of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) containing combinations of resistance mutations for zidovudine (AZT) (M41L and T215Y) or lamivudine (M184V) have been determined as inhibitor complexes. Minimal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::893151287eb8e2bbba0ecbbba2941ba4
https://doi.org/10.1128/jvi.76.19.10015-10019.2002
https://doi.org/10.1128/jvi.76.19.10015-10019.2002
Autor:
David I. Stuart, P.P. Chamberlain, Louise E. Bird, Kurt Weaver, Steven A. Short, C.E. Nichols, Jingshan Ren, David K. Stammers
Publikováno v:
Journal of Molecular Biology. 312:795-805
Mutations at either Tyr181 or Tyr188 within HIV-1 reverse transcriptase (RT) give high level resistance to many first generation non-nucleoside inhibitors (NNRTIs) such as the anti-AIDS drug nevirapine. By comparison second generation inhibitors, for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5b8fb41db853506ad141c4b9f5b9b2a
https://doi.org/10.1006/jmbi.2001.4988
https://doi.org/10.1006/jmbi.2001.4988
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Kurt Weaver, C.E. Nichols, P.P. Chamberlain, Steven A. Short, Jingshan Ren, David K. Stammers
Publikováno v:
Journal of molecular biology. 336(3)
Leu100Ile, Val106Ala and Val108Ile are mutations in HIV-1 reverse transcriptase (RT) that are observed in the clinic and give rise to resistance to certain non-nucleoside inhibitors (NNRTIs) including the first-generation drug nevirapine. In order to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cf8ef04cd017063760050b3cc23462e
http://ora.ox.ac.uk/objects/uuid:a4fe4f40-f18f-44c5-8b19-0f0aac01ff92
http://ora.ox.ac.uk/objects/uuid:a4fe4f40-f18f-44c5-8b19-0f0aac01ff92
Autor:
David I. Stuart, Simon J. Davis, Lester G. Carter, Thomas S. Walter, C.E. Nichols, Geoff Sutton, N.R. Brown, Christopher Love, P.P. Chamberlain, R.A. Robinson, Louise E. Bird, M. C. Sleeman, Robert J.C. Gilbert, W.-C. Hon, Nicola G. A. Abrescia, F. Kimberley, Guillaume Stewart-Jones, R. Manso-Sancho, M. Vuong, J. Welburn, T. Batuwangala, Maria Harkiolaki, J. Brown, Erika J. Mancini, David K. Stammers, E. Dubinina, E Y Jones, Zhihong Zhang, J. A. Fennelly, Karl Harlos, N. Schueller, A R Aricescu, Jane A. Endicott, Raymond J. Owens
An initial tranche of results from day-to-day use of a robotic system for setting up 100 nl-scale vapour-diffusion sitting-drop protein crystallizations has been surveyed. The database of over 50 unrelated samples represents a snapshot of projects cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77fbec6497a0f9a73ad9e7a57d155699
http://sro.sussex.ac.uk/id/eprint/52565/1/S0021889803002012.pdf
http://sro.sussex.ac.uk/id/eprint/52565/1/S0021889803002012.pdf
Autor:
Jingshan Ren, David K. Stammers, Louise E. Bird, P.P. Chamberlain, Guillaume Stewart-Jones, David I. Stuart
Publikováno v:
Protein expression and purification. 27(1)
A purification procedure is described for the isolation of recombinant HIV-2 reverse transcriptase expressed in Escherichia coli. The p68 subunit is expressed, in the absence of induction, and use of a heparin-Sepharose column produces substantially
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebe5b33d0fafa1c7fc07a8f0d1ebbf52
http://ora.ox.ac.uk/objects/uuid:d5642997-5913-4de3-8178-baff9654c2f6
http://ora.ox.ac.uk/objects/uuid:d5642997-5913-4de3-8178-baff9654c2f6