Výsledky vyhledávání - "P.N.M. Demacker"

Smoking or its cessation does not alter the susceptibility toin vitroLDL oxidation

Autor: A.F.H. Stalenhoef, F. W. P. J. Van Den Berkmortel, P.N.M. Demacker, Th. Thien, H.C.H. Wollersheim

Publikováno v: European Journal of Clinical Investigation. 30:972-979

Background Enhanced induction of low density lipoprotein (LDL) oxidation may play a role in the increased cardiovascular risk in smokers. We determined LDL oxidisability in vitro in non-smokers, smokers and in subjects after smoking cessation. Patien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a1aa35840f21f16dca45b4ae2b0e8cb0
https://doi.org/10.1046/j.1365-2362.2000.00739.x

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LPS-induced cytokine production and expression of β2-integrins and CD14 by peripheral blood mononuclear cells of patients with homozygous familial hypercholesterolemia

Autor: Chantal P. Bleeker Rovers, N. de Bont, J.W.M. van der Meer, Cor Jacobs, Mihai G. Netea, A.F.H. Stalenhoef, B.J. Kullberg, P.N.M. Demacker

Publikováno v: Atherosclerosis, 141, 99-105
ResearcherID
Atherosclerosis, 141, 1, pp. 99-105
Atherosclerosis, 141, pp. 99-105
Atherosclerosis, 141, 99-105. Elsevier sci ireland ltd

It has been suggested that proinflammatory cytokines such as tumor necrosis factor-alpha (TNF) and interleukin-1beta (IL-1), as well as adhesion molecules such as beta2-integrins and CD14, play a role in the pathogenesis of atherosclerosis. Familial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ff40388352291d6ac2f8c273cdbc185
https://doi.org/10.1016/s0021-9150(98)00152-x

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Glutathione homeostasis is disturbed in CD4-positive lymphocytes of HIV-seropositive individuals

Autor: Liesbeth Jacobs, Henk J. Blom, P.N.M. Demacker, Peter P. Koopmans, Trees J.G. Verver-Jansen, A.J.A.M. van der Ven, J.W.M. van der Meer, Wilbert H.M. Peters

Publikováno v: European Journal of Clinical Investigation. 28:187-193

Background Numerous in vitro tests have suggested that a disturbed cellular glutathione homeostasis plays an important role in the pathogenesis of human immunodeficiency virus (HIV) infection. Methods Using validated high-performance liquid chromatog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd2f3ec4f83f3c926a5f28ed5c430c41
https://doi.org/10.1046/j.1365-2362.1998.00267.x

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Inflammatory mediators in children with protein-energy malnutrition

Autor: J. van der Meer, Norbert Peshu, L. Mulder, P.N.M. Demacker, Robert Sauerwein, Brett Lowe, J.A. Mulder, Kevin Marsh

Publikováno v: The American Journal of Clinical Nutrition, 65, 1534-1539
The American Journal of Clinical Nutrition, 65, pp. 1534-1539
The American Journal of Clinical Nutrition, 65, 5, pp. 1534-1539

Edema is a typical sign in kwashiorkor, which is present in a subset of patients with protein-energy-malnutrition (PEM). The pathophysiology of this edema is not well established. One of the abnormalities found in kwashiorkor is reduced concentration

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60559b3397013804116c75b76404150
https://doi.org/10.1093/ajcn/65.5.1534

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Circulating and ex vivo production of pyrogenic cytokines and interleukin-1 receptor antagonist in 123 patients with fever of unknown origin

Autor: E.M.H.A. de Kleijn, J.A.M. van Druten, G.J. Pesman, J.W.M. van der Meer, J.P.H. Drenth, P.N.M. Demacker

Publikováno v: The Journal of Infectious Diseases, 175, pp. 191-195
Journal of Infectious Diseases, 175, 1, pp. 191-195
Journal of Infectious Diseases, 175, 191-195
The Journal of Infectious Diseases, 175, 191-195

Circulating and ex vivo production of interleukin (IL)-lP, tumor necrosis factor (TNF)-a, IL-6, and IL-1 receptor antagonist (ra) and the diagnostic utility of these cytokines were studied in 123 patients with fever of unknown origin (FUO). Diagnoses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::792dd885720c245646399192741bbe34
https://hdl.handle.net/2066/15103

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Low density lipoprotein receptor deficient mice are protected against endotoxemia and severe gram-negative infections

Autor: J.W.M. van der Meer, P.N.M. Demacker, A.F.H. Stalenhoef, O.C. Boerman, Mihai G. Netea, Ineke Verschueren, B.J. Kullberg

Publikováno v: Journal of Clinical Investigation, 97, 1366-1372
Journal of Clinical Investigation, 97, 6, pp. 1366-1372
Journal of Clinical Investigation, 97, pp. 1366-1372
European Journal of Clinical Investigation, 97, 6, pp. 1366-1372
European Journal of Clinical Investigation, 97, 1366-1372

Lipoproteins can bind lipopolysaccharide (LPS) and decrease the LPS-stimulated production of pro-inflammatory cytokines. We investigated the effect of increased plasma concentrations of low-density-lipoproteins (LDL) on survival and cytokine producti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1172f799ec3752c853ed6b0aaa8f3cf9
https://hdl.handle.net/2066/24283

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Decreased resistance against in vitro oxidation of LDL from patients with familial defective apolipoprotein B-100

Autor: Joep C. Defesche, A.F.H. Stalenhoef, Henne A. Kleinveld, J.J.P. Kastelein, P.N.M. Demacker

Publikováno v: Arteriosclerosis and thrombosis, 14(3), 489-493. American Heart Association

Familial defective apolipoprotein B-100 (FDB) is caused by a mutation in the receptor-binding region of apolipoprotein B-100, the structural protein of the low-density lipoprotein (LDL) particle. We studied the effect of this mutation on the composit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dbea0ff7f153ebdd2c4aec55fd0b7bd
https://doi.org/10.1161/01.atv.14.3.489

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CIRCULATING CONCENTRATIONS AND PRODUCTION OF CYTOKINES AND SOLUBLE RECEPTORS IN RHEUMATOID ARTHRITIS PATIENTS: EFFECTS OF A SINGLE DOSE METHOTREXATE

Autor: P.N.M. Demacker, Pilar Barrera, J.W.M. van der Meer, H. Gallati, L. B. A. Van De Putte, A. M. T. Boerbooms

Publikováno v: Rheumatology. 33:1017-1024

Methotrexate (MTX) is an effective treatment for RA and its effects may be partly due to cytokine modulation. Herein, we assessed the effects of a single MTX dose on the production and circulating concentrations of several cytokines and soluble recep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a0a1ece61238e0709c2db8a5a2b028
https://doi.org/10.1093/rheumatology/33.11.1017

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Single-spin density-gradient ultracentrifugation vs gradient gel electrophoresis: two methods for detecting low-density-lipoprotein heterogeneity compared

Autor: D. W. Swinkels, P.N.M. Demacker, A.F.H. Stalenhoef, T. P. J. Dormans, J. C. M. Hendriks, J. De Graaf

Publikováno v: Clinical Chemistry. 37:853-858

Single-spin density-gradient ultracentrifugation (DUC) has proven to be a reproducible method for detection of low-density-lipoprotein (LDL) heterogeneity. Recently another method has been described for this: gradient gel electrophoresis (GGE) of ser

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c220494ed3a9fc7ef6f4f17571f735c
https://doi.org/10.1093/clinchem/37.6.853

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Increased removal of remnants of triglyceride-rich lipoproteins on a diet rich in polyunsaturated fatty acids

Autor: A.F.H. Stalenhoef, P.M.J. Stuyt, Martijn B. Katan, P.N.M. Demacker, I. G. M. Reijnen

Publikováno v: European Journal of Clinical Investigation, 21, 197-203
European Journal of Clinical Investigation 21 (1991)

We studied the effect of two diets, one rich in polyunsaturated and the other in saturated fatty acids, on the postprandial processing of exogenous and endogenous triglyceride-rich lipoproteins (chylomicrons, very-low-density lipoproteins, and their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb0b3015c8f6dffcfe7be1dae1ed6445
https://doi.org/10.1111/j.1365-2362.1991.tb01809.x

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