Increased glutamine synthetase but normal EAAT2 expression in platelets of ALS patients

Autor: L.H. van den Berg, Henk A. Spierenburg, Ineke W. M. Bos, C.F. Meine Jansen, G. Van Willigen, P.N.E. de Graan, G. Hoogland

Publikováno v: Neurochemistry International. 48:306-311

Amyotrophic lateral sclerosis is a fatal neurodegenerative disease and glutamate excitotoxicity has been implicated in its pathogenesis. Platelets contain a glutamate uptake system and express components of the glutamate–glutamine cycle, such as th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2b8592c1032299c5013c1cdb3ebb27b
https://doi.org/10.1016/j.neuint.2005.09.009

Thrombin-stimulated glutamate uptake in human platelets is predominantly mediated by the glial glutamate transporter EAAT2

Autor: Henk A. Spierenburg, P.N.E. de Graan, Frank Kupper, G. Van Willigen, Ineke W. M. Bos, O. van Nieuwenhuizen, G. Hoogland

Publikováno v: Kupper, F 2005, ' Thrombin-stimulated glutamate uptake in human platelets is predominantly mediated by the glial glutamate transporter EAAT2 ', Neurochemistry International, vol. 47, no. 7 . https://doi.org/10.1016/j.neuint.2005.06.006
Neurochemistry International, 47(7). Elsevier Limited

Glutamate toxicity has been implicated in the pathogenesis of various neurological diseases. Glial glutamate transporters play a key role in the regulation of extracellular glutamate levels in the brain by removing glutamate from the extracellular fl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3dfce904e0f4c35ca819fc6a790a8a0
https://doi.org/10.1016/j.neuint.2005.06.006

Mini-Review: Morphological changes in the human epileptogenic hippocampus

Autor: Govert Hoogland, C.W.M. van Veelen, E. A. Proper, P.N.E. de Graan

Publikováno v: Neuroscience Research Communications. 29:129-146

The availability of surgical tissue from epilepsy patients and the development of different animal models have increased our knowledge about the morphological changes in the epileptogenic brain. In this review we focus on the main morphopathological

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a2453a962e36c7e8dfe289d11a2b16e
https://doi.org/10.1002/nrc.10006

Ba2+ replaces Ca2+/calmodulin in the activation of protein phosphatases and in exocytosis of all major transmitters

Autor: W.E.J.M. Ghijsen, W.H. Gispen, F.H. Lopes da Silva, Matthijs Verhage, Victor M. Wiegant, Frans Boomsma, Jacques J. H. Hens, P.N.E. de Graan

Publikováno v: European journal of pharmacology, 291, 387. Elsevier
European Journal of Pharmacology. Molecular Pharmacology Section, 291, 387-398. Elsevier

Exocytosis from nerve terminals is triggered by depolarization-evoked Ca 2+ entry, which also activates calmodulin and stimulates protein phosphorylation. Ba 2+ is believed to replace Ca 2+ in triggering exocytosis without activation of calmodulin an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce4c554853c35e737facbfa50dc37de3
https://doi.org/10.1016/0922-4106(95)90081-0

Altered synaptic transmission in the hippocampus of transgenic mice with enhanced central nervous systems expression of interleukin-6

Autor: A. Puro, Ruben V. Hernandez, T.E. Nelson, Christine Hao, A. Olde Engberink, P.N.E. de Graan, Donna L. Gruol, Salvador Huitron-Resendiz

Publikováno v: Brain, behavior, and immunity. 26(6)

Elevated levels of the inflammatory cytokine interleukin-6 (IL-6) occur in a number of CNS disorders. However, little is known about how this condition affects CNS neuronal function. Transgenic mice that express elevated levels of IL-6 in the CNS sho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61da3bf48b8406448ff7c0dd94355960
https://pubmed.ncbi.nlm.nih.gov/22609298