Combinatorial multimer staining and spectral flow cytometry facilitate quantification and characterization of polysaccharide-specific B cell immunity

Autor: D. Hoving, A.H.C. Marques, W. Huisman, B.A. Nosoh, A.C. de Kroon, O.R.J. van Hengel, B.R. Wu, P.M. van Helden, B.C. Urban, N. Dhar, D.M. Ferreira, G. Kwatra, C.H. Hokke, S.P. Jochems

Bacterial capsular polysaccharides are important vaccine immunogens. However, the study of polysaccharide-specific immune responses has been hindered by technical restrictions. Here, we developed and validated a high-throughput method to analyse anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b5e5cf10afaef701d9c3ec8e097b65cb
https://doi.org/10.1101/2023.03.07.531507

Timing of decontamination and treatment in case of percutaneous VX poisoning: A mini review

Autor: Marloes J.A. Joosen, Daan Noort, Marcel J. van der Schans, Willem C. Kuijpers, Herman P.M. van Helden

Publikováno v: Chemico-Biological Interactions. 203:149-153

Low volatile organophosphorous nerve agents such as VX, will most likely enter the body via the skin. The pharmacokinetics of drugs such as oximes, atropine and diazepam, are not aligned with the variable and persistent toxicokinetics of the agent. R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceaa05d95ae6ca72138ac642c351e47b
https://doi.org/10.1016/j.cbi.2012.10.002

Treatment efficacy in a soman-poisoned guinea pig model: added value of physostigmine?

Autor: Marloes J.A. Joosen, Herman P.M. van Helden, August B. Smit

Publikováno v: Archives of Toxicology, 3, 85, 227-237
Joosen, M J A, Smit, A B & van Helden, H P 2011, ' Treatment efficacy in a soman-poisoned guinea pig model: added value of physostigmine? ', Archives of Toxicology, vol. 85, no. 3, pp. 227-237 . https://doi.org/10.1007/s00204-010-0571-3
Archives of Toxicology
Archives of Toxicology, 85(3), 227-237. Springer Verlag

Current treatment of organophosphate poisoning is insufficient, and survivors may suffer from long-lasting adverse effects, such as cognitive deficits and sleep-wake disturbances. In the present study, we aimed at developing a guinea pig model to inv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::016002b2ff6738941b286bd9057fa7c3
https://doi.org/10.1007/s00204-010-0571-3

Percutaneous Exposure to VX: Clinical Signs, Effects on Brain Acetylcholine Levels and EEG

Autor: Marloes J.A. Joosen, Herman P.M. van Helden, Marcel J. van der Schans

Publikováno v: Neurochemical Research. 33:308-317

The nerve agent VX has a variable and delayed absorption through the skin, which may have implications for treatment regimens. In the present study, central and peripheral effects of percutaneous VX intoxication were investigated in hairless guinea p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::413fdc44869c374f2d2580e45d60809e
https://doi.org/10.1007/s11064-007-9508-5

Asthmalike Symptoms Following Intratracheal Exposure of Guinea Pigs to Sulfur Mustard Aerosol: Therapeutic Efficacy of Exogenous Lung Surfactant Curosurf and Salbutamol

Autor: Willem C. Kuijpers, Herman P.M. van Helden, Robert V. Diemel

Publikováno v: Inhalation Toxicology. 16:537-548

The purpose of the present study was to investigate: (1) the acute effects of sulfur mustard on airway, lung, and surface tension of bronchoalveolar lavage fluid (BALfluid) in guinea pigs following intratracheal (i.t.) exposure to 1LD50 of an aerosol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08fa3897a18930b6335ec3350bf3e69f
https://doi.org/10.1080/08958370490442520