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pro vyhledávání: '"P.M. Rabbat"'
Autor:
James Z. Deng, S. D. Lewis, P.M. Rabbat, Craig A. Coburn, Terry A. Lyle, J. P. Vacca, Bobby J. Lucas, Daniel R. McMasters, Julie A. Krueger, B. Strulovici, Youwei Yan, Peter D. Williams, Lawrence Kuo, Christopher S. Burgey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:4411-4416
Thrombin-inhibitor X-ray crystal structures, in combination with the installation of binding elements optimized within the pyrazinone series of thrombin inhibitors, were utilized to transform a weak triazolopyrimidine lead into a series of potent oxa