Zobrazeno 1 - 10
of 197
pro vyhledávání: '"P.M. Laduron"'
Publikováno v:
Neuroscience. 68:151-157
Interleukin-1 is known to exert pleiotropic effects in host defence mechanisms and in inflammation. Chronic pain, inflammation and interleukin-1 beta enhance the production of substance P. Recently, axonal transport of opiate receptors was found to i
Autor:
Jeremy Pratt, A. Doble, Serge Mignani, Jean-Charles Blanchard, Jacques Lavayre, J.-M. Stutzmann, Michel Barreau, O. Piot, J. Rataud, P.M. Laduron, Patrick Jimonet, C. Malgouris, Alain Boireau, Michel Reibaud
Publikováno v:
Bioorganic & Medicinal Chemistry. 2:793-798
RP 66055, a riluzole derivative, has been characterized as a potent anticonvulsant and in vivo neuroprotective agent.
Autor:
Francois Montier, Veronique Fardin, Jean-Francois Peyronel, Saliha Moussaoui, P.M. Laduron, A. Carruette, Claude Garret
Publikováno v:
Regulatory Peptides. 46:24-30
Autor:
Saliha Moussaoui, Jean-Charles Blanchard, Claude Garret, P.M. Laduron, Francois Montier, A. Carruette
Publikováno v:
British Journal of Pharmacology. 109:259-264
1. The non-peptide neurokinin NK1-receptor antagonist, RP 67580 (3aR, 7aR), a perhydroisoindolone derivative, powerfully reduced plasma extravasation in rat hind paw skin induced by local application of xylene (ID50 = 0.03 mg kg-1, i.v.) or capsaicin
Publikováno v:
European Journal of Neuroscience. 5:449-453
Axonal transport of the vesicular monoamine transporter was assayed in the rat brain by in vivo binding of the specific ligand [3H]reserpine. Because of the marked localization of reserpine binding sites in dopaminergic cell bodies and nerve terminal
Autor:
Serge Mignani, P.M. Laduron, A. Doble, C. Gueremy, Zundel Jl, O. Piot, Alain Truchon, Jean-Charles Blanchard, Jean-Francois Peyronel, Jean-Luc Malleron
Publikováno v:
Journal of Medicinal Chemistry. 36:1194-1202
A series of new indole derivatives (2-28) has been prepared in the search for novel 5-HT uptake inhibitors. These compounds were obtained by the condensation of N-(chloroalkyl) naphthalenesultam derivatives with the appropriate amine in presence of a
Publikováno v:
Biochemical Pharmacology. 42:2265-2274
The regulation of neurotensin receptors was studied in vitro in primary cultures of neuronal cells. High affinity receptors for [3H]neurotensin were found in homogenates and at the cell surface of intact neurons cultured from the brain of rat embryos
Autor:
Adam Doble, Valérie Olivier, Michel Aubeneau, Jean-Charles Blanchard, Pierre Dubedat, Alain Boireau, P.M. Laduron, Jean-Marie Miquet, Fabien Richard
Publikováno v:
Journal of Pharmacy and Pharmacology. 43:798-801
The effects of different potassium channel blockers on tritiated dopamine ([3H]DA) release were investigated in rat striatal slices in the presence of pargyline and nomifensine (10 μM each). 4-Aminopyridine (4-AP; 10 and 30 μM) and 3,4-diaminopyrid
Effect of γ-butyrolactone on the retrograde axonal transport of neurotensin in dopaminergic neurones
Publikováno v:
European Journal of Pharmacology. 186:133-136
γ-Butyrolactone is a drag known to inhibit the flow of electrical impulses in dopaminergic neurones and to prevent dopamine release in the striatum. In this study, we investigated the effects of this compound on the retrograde transport of neurotens
Publikováno v:
Neuropeptides. 16:15-20
Since an enhanced retrograde axonal transport of receptor-bound opiate was observed in the ligated vagus nerves of rats treated chronically with alcohol, we decided to look at the anterograde axonal transport of substance P in the same experimental c