Zobrazeno 1 - 10
of 26
pro vyhledávání: '"P.M. Dortant"'
Publikováno v:
Food and Chemical Toxicology. 50:927-935
Because of the relatively high human oral exposure to polycyclic aromatic hydrocarbons (PAHs) compared to the inhalation exposure, the known carcinogenicity of this type of compounds and the limited data from oral studies available with polycyclic ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44b56c57f6add777463084af5abd5b05
https://doi.org/10.1016/j.fct.2011.12.003
https://doi.org/10.1016/j.fct.2011.12.003
Publikováno v:
Food and Chemical Toxicology. 39:55-65
Ochratoxin A (OTA) is a mycotoxin found in food and feedstuffs of plant and animal origin. OTA exposure is related to nephropathy in humans. Age-related differences, especially in nephro- and immunotoxicity of OTA, were investigated in young adult (a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49c8d25a8e905efb8103d0541a80fa47
https://doi.org/10.1016/s0278-6915(00)00107-1
https://doi.org/10.1016/s0278-6915(00)00107-1
Publikováno v:
Immunology. 96:298-306
The naturally occurring trans-isomer of urocanic acid (trans-UCA), found in the stratum corneum, absorbs ultraviolet light (UV) and isomerizes to the cis-form. Cis-UCA has been shown to impair some cellular immune responses, and has been proposed as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1136638f0cd34ad7bb257fa0b4d31b34
https://doi.org/10.1046/j.1365-2567.1999.00698.x
https://doi.org/10.1046/j.1365-2567.1999.00698.x
Publikováno v:
Toxicology and Applied Pharmacology. 136:179-185
To study the possible age-dependent ototoxic effects of tobramycin a subacute toxicity study was performed. To young adult (3 months) and old (27-30 months) female Wag-Rij rats 0, 10, 40, and 160 mg tobramycin sulfate/kg was administered subcutaneous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba3ad750f1047e928a9bfca7f4d88e37
https://doi.org/10.1006/taap.1996.0022
https://doi.org/10.1006/taap.1996.0022
Autor:
H. van Loveren, A.P.J. Verlaan, E. Geerse, P. A. Steerenberg, H.B. Bueno-de-Mesquita, Y. Sontag, P.M. Dortant, H. van der Vliet, J. Garssen, Wim G. Goettsch
Publikováno v:
Cancer Letters. 114:187-189
The effects of quercetin (4%) on UVB-induced carcinogenesis and immunosuppression were studied in hairless SKH-1 mice exposed daily to suberythemal UVB for 12/13 and 16/17 weeks. Macroscopic and microscopic examinations showed that quercetin did not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d32540f3230a2d7a38d6f72fba26f7c6
https://doi.org/10.1016/s0304-3835(97)04659-4
https://doi.org/10.1016/s0304-3835(97)04659-4
Publikováno v:
Laboratory animals. 33(1)
Two different sources of ultraviolet B (UVB) radiation, an electronically controlled UVB exposure unit, containing FS40 tubes, and a hand-held Kromayer lamp, were evaluated for actual irradiance in W/m2 and spectra (physical dosimetry and biological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57abf5e647ad5edd9a5b6293661adacf
https://pubmed.ncbi.nlm.nih.gov/10759393
https://pubmed.ncbi.nlm.nih.gov/10759393
Publikováno v:
Biologicals : journal of the International Association of Biological Standardization. 25(4)
The aim of this study was to evaluate the possible carcinogenic potential of residual DNA derived from immortalized and possibly tumorigenic cell lines due to activated oncogenic sequences (oncogenes). These cell lines have been used for the producti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b655a822f307713f696e19bc43563a1
https://pubmed.ncbi.nlm.nih.gov/9467034
https://pubmed.ncbi.nlm.nih.gov/9467034
Autor:
H.J. van Kranen, C. T. M. Van Oostrom, H. van Steeg, A. De Vries, P.M. Dortant, E. D. Kroese, C. W. Van Der Houven Van Oordt, C. F. Van Kreijl, P. W. Wester
Publikováno v:
Carcinogenesis. 18(5)
E mu-pim-1 transgenic mice are predisposed to develop lymphomas. Due to their low spontaneous tumour incidence and their increased sensitivity towards the lymphomagen ethylnitrosourea these mice may present an interesting model for short-term carcino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f67bc66fac7dc64cd071621ebf4f2c5
https://pubmed.ncbi.nlm.nih.gov/9163683
https://pubmed.ncbi.nlm.nih.gov/9163683
Autor:
Wim G. Goettsch, H. van Loveren, Mary Norval, P.M. Dortant, A.P.J. Verlaan, Y. Sontag, H. van de Vliet, P. A. Steerenberg, Neil K. Gibbs, H.B. Bueno-de-Mesquita, J. Garssen, L. Geerse
Publikováno v:
Photochemistry and photobiology. 65(4)
— Ultraviolet is thought to induce skin tumors by its dual activity as a mutagenic agent and a suppressor of cell-mediated immunity. In the present study the effects of quercetin, a flavonoid-containing compound, on carcinogenesis and immunosuppres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8451788953df4e232ab2e8adbab1294e
https://pubmed.ncbi.nlm.nih.gov/9114752
https://pubmed.ncbi.nlm.nih.gov/9114752
Autor:
Arja de Klerk, Tineke M. P. T. Herremans, Wim G. Goettsch, P.M. Dortant, Johan Garssen, Frank R. de Gruijl, Henk Van Loveren
Publikováno v:
Photochemistry and photobiology. 63(5)
A rat infection model using the bacterial pathogen Listeria monocytogenes was employed to analyze the im-munosuppressive activity of UVB radiation. Rats were exposed to suberythemal doses of UVB radiation for 5 or 7 consecutive days, using Kromayer o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f91e6c88d647539d63965e45b1f5b3b3
https://pubmed.ncbi.nlm.nih.gov/8628759
https://pubmed.ncbi.nlm.nih.gov/8628759