Výsledky vyhledávání

Preliminary crystallographic data for Pneumocystis carinii dihydrofolate reductase

Autor: J.N. Champness, David I. Stuart, S.P. Ballantine, C.J. Delves, David K. Stammers, E Y Jones, A Achari, P.K. Bryant

Dihydrofolate reductase from Pneumocytis carinii has been crystallized in a form suitable for high resolution X-ray diffraction studies. Recombinant enzyme that had been refolded following solubilization in guanidinium hydrochloride was crystallized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cf64e09978e5a32b1eafa8307b8a82e
https://ora.ox.ac.uk/objects/uuid:919a6baf-fb4d-4bb9-9fad-2d8342515713

Zobrazit plný text záznamu

Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase

Autor: J. Rosemond, P.K. Bryant, David K. Stammers, D. O. Somers, J.N. Champness, Aniruddha Achari

Sulfonamides were amongst the first clinically useful antibacterial agents to be discovered. The identification of sulfanilamide as the active component of the dye Prontosil rubrum led to the synthesis of clinically useful analogues. Today sulfametho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdb5ca4005a12bd847ed25ee48a3d51f
https://doi.org/10.1038/nsb0697-490

Zobrazit plný text záznamu

The structure of Pneumocystis carinii dihydrofolate reductase to 1.9 A resolution

Autor: J.N. Champness, David K. Stammers, C.J. Delves, S.P. Ballantine, P.K. Bryant, Aniruddha Achari

Background: The fungal pathogen Pneumocystis carinii causes a pneumonia which is an opportunistic infection of AIDS patients. Current therapy includes the dihydrofolate reductase (DHFR) inhibitor trimethoprim which is selective but only a relatively

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86ac09d15a02a27f282e578ff75f3779
https://ora.ox.ac.uk/objects/uuid:3be2c6ab-e5ba-43b6-b40d-a783c76f0afc

Zobrazit plný text záznamu

Evidence of a molecular barrier limiting susceptibility of humans, cattle and sheep to chronic wasting disease

Autor: Gregory J. Raymond, Alex Bossers, Katherine I. O'Rourke, Michael W. Miller, Linda E. McHolland, Lynne D. Raymond, Mari A. Smits, P.K. Bryant, Byron Caughey, Elizabeth S. Williams

Publikováno v: The EMBO journal. 19(17)

Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy (TSE) of deer and elk, and little is known about its transmissibility to other species. An important factor controlling interspecies TSE susceptibility is prion protein (PrP)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d531a5d0a422eb8cc4cda1d2e81e5b7
https://pubmed.ncbi.nlm.nih.gov/10970836

Zobrazit plný text záznamu

2.0 A X-ray structure of the ternary complex of 7,8-dihydro-6-hydroxymethylpterinpyrophosphokinase from Escherichia coli with ATP and a substrate analogue

Autor: David L. Scott, D. O. Somers, J. Rosemond, David K. Stammers, P.K. Bryant, Aniruddha Achari, J.N. Champness

Publikováno v: FEBS letters. 456(1)

The X-ray crystal structure of 7,8-dihydro-6-hydroxymethylpterinpyrophosphokinase (PPPK) in a ternary complex with ATP and a pterin analogue has been solved to 2.0 A resolution, giving, for the first time, detailed information of the PPPK/ATP intermo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b95650978682e8b355606b27414ff667
https://pubmed.ncbi.nlm.nih.gov/10452528

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Vyhledávací nástroje:

Upřesnit hledání