Activation of mutagens by hepatocytes and liver 9000 × g supernatant from human origin in the Salmonella typhimurium mutagenicity assay

Autor: J.M. Neis, P.J.L. van Gemert, R.P. Bos, Sing Hiem Yap, P. T. Henderson, Hennie M.J. Roelofs

Publikováno v: Mutation Research/Environmental Mutagenesis and Related Subjects. 164:41-51

The mutagenicity of 10 known genotoxic compounds, of several chemical classes, was measured in Salmonella typhimurium mutagenicity assays comprising isolated human hepatocytes or human liver 9000 X g supernatant (S9) from 4 different individuals, as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c85e2e5503b246e188d8148577630a1
https://doi.org/10.1016/0165-1161(86)90040-3

Dutch Pharmacological Meeting 1984

Autor: J. Mooy, Margot J. H. de Reus, G. R. Mohn, Ch. M. Leijdekkers, J. Van Harten, H. J. M. Salden, J. G. Loeber, M. Raghoebar, R. J. M. ten Berge, Joop S. de Graaf, W. de Jong, E. M. van der Beek, C. A. M. Van Ginneken, P. W. Wester, J. B. M. van Driel, Peter M. Edelbroek, Hans Rollema, C. A. J. M. Vulders, D. J. Touw, J. J. Grote, Pramod R. Saxena, E. I. Krajnc, Frans P. Nijkamp, J. Kreukniet, Frederik A. de Wolff, H. Burbach, F. C. Hillen, W. Kruizinga, F. W. J. Gribnau, P. H. Hofman, M. J. A. M. Franssen, K. H. Rahn, Frans G. M. Russel, Hans J. Steenbergen, E. Laban, D.J. de Wildt, H. Wollersheim, Npe Vermeulen, H. M. E. Scheres, M. Van Der Graaff, L. R. Remeyer, E. Ronald de Kloet, M. C. M. Rijk, H. J. H. Salden, F. J. Jongeneelen, Theo Mulder, H. E. Sluiter, T. Bultsma, A. B. M. Klaassen, M. v. Baak, J. A. H. Raaijmakers, A. J. van Rozen, J. F. M. Nouws, R. A. P. Koene, N. Verbeke, H. L. G. H. Tiemessen, B. J. L. Kothuis, Cor J. de Vos, R.P. Bos, J. G. P. Peters, Frans W. H. M. Merkus, C. E. M. Zoetemelk, Mjmc Thoolen, M. R. Linschoten, P. T. A. Schellekens, W. Buijs, Th. Thien, H. Th. M. Folgering, L. Conings, D. K. F. Meijer, J. J. Cox van Put, J. De Gier, Ferdi Engels, W. Kateman, P. Lomax, F. Th. M. Huysmans, F. X. R. van Leeuwen, C. J. Van Boxtel, Y. Tan, M. J. Krielaart, G. A. Charbon, J. G. Vos, B. J. 't Hart, J. Jelinek, P. van Heuven-Nolsen, W. J. Wijnands, A. de Jonge, G. R. Bolt, U. R. Tjaden, K. U. Leuven, Durk Oijkstra, Lambert H.M. Janssen, C. M. M. Veldhoven, H. M. N. Nievelstein, E. J. AriËns, H. M. J. Roelofs, A. van 't Laar, L. H. van den Berg, H. N. Doods, F. Corstens, M. v. Hengstum, O. Driessen, R. Groothedde, G. B. van der Voet, W. Kuijpers, A. de Klerk, E. Schönbaum, D. D. Breimer, B. van Ommen, C. A. van der Heijden, M. v. Hooff, E. A. De Bruijn, Hendrik Timmerman, L. C. M. Baars, P van Brummelen, C. T. A. Evelo, A. J. Beld, H. H. W. Thljssen, G. Aué, R. van Doorn, H. A. M. G. Vaessen, J. Fennis, Theo B.A. Mulder, W. v. d. Broek, G. K. Terpstra, A. T. van Oosterom, Cor J. Grol, R. A. Lefebvre, P. A. Van Zwieten, A. C. Wouterse, Rob B. M. Anzion, J. F. Rodrigues De Miranda, C. Neef, R. S. Oosting, A. Van Der Gen, C. H. Kleinbloesem, Marian W. Tijhuis, Yechiel A. Hekster, H. A. J. Struyker Boudier, C. L. A. van Herwaarden, Bob Wilffert, Dora Mastebroex, E. A. van der Velde, A. S. P. M. Breed, H. L. M. Siero, Gerard van Aalst, J. L. G. Theuws, F. A. De Wolff, J. Rozing, E. I. Krajc, R. H. B. Meyboom, M. A. M. ten Broeke, J. Festen, P.J.L. van Gemert, A. P. I. Jzerman, Hans Wynberg, Alan Horn, H. J. E. Reeuwijk, B. O Osterhuis, R. Dorlas, P. A. M. Peeters, J. Willemsen, L. M. de Brauw, Jan B. de Vries, L. B. A. van de Putte, Alan S. Horn, J. H. Canton, H. J. E. M. Reeuwijk, M. Schols, J. A. M. Raaijmakers, Marcus Bogaert, J. van Noordwijk, Durk Dijkstra, P.Th. Henderson, Peter P. Koopmans, J. W. J. Lammers, T. B. Vree, C. J. H. van de Velde, C. J. Van Koppen, Bernard Hazelhoff, Jaap Wilting, H. M. Pinedo, W. Kuypers, C. M. Ruland, H. A. J. Struyker-Boudier, J. M. Neis, P. B. M. W. M. Timmermans, H. O. Kalkman, P. R. M. Kerklaan, P. A. F. Jansen, J. Peter, J. H. Koeman, H. J. Huidekoper, Mj Mathy, A.F. De Schaepdryver, R.A.M. van der Hoeven, Jos F.M. Smits, Tjeerd van den Berg, E. H. den Tonkelaar, J. W. M. Lenders, P. Sandor, C. A. v. d. Heijden, G. A. Wassink, O. Castelein, P. H. Th. J. Slee

Publikováno v: Pharmaceutisch Weekblad. 6:163-184

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0feb23f7a988a0d11f3171454f7aae1
https://doi.org/10.1007/bf01954045

Mutagenicity towards Salmonella typhimurium of some known genotoxic agents, activated by isolated hepatocytes of monkey (Macaca fascicularis)

Autor: P.Th. Henderson, P.J.L. van Gemert, Hennie M.J. Roelofs, J.M. Neis

Publikováno v: Mutation Research/Environmental Mutagenesis and Related Subjects. 164:139-143

This paper describes some striking differences between isolated human and monkey hepatocytes in their capacity to activate some known genotoxic agents into products mutagenic towards Salmonella typhimurium . Isolated monkey hepatocytes, in contrast t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::08c0b4f6aa7b4d121d8cf33efddbedee
https://doi.org/10.1016/0165-1161(86)90005-1

Comparison of the mutagenicities of 4-aminobiphenyl and benzidine in the Salmonella/microsome, Salmonella/hepatocyte and host-mediated assays

Autor: P.J.L. van Gemert, R.P. Bos, R. van Doorn, P.Th. Henderson, E. Yin-van de Hurk

Publikováno v: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 93:317-325

The applicability of suspensions of rat hepatocytes as the metabolic factor in a bacterial mutagenicity test was studied. Therefore, mutagenicity of 4-aminobiphenyl and benzidine towards the Salmonella typhimurium strains TA1538 and TA100 in the pres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::96b70cb80417a5bde049fe4cad932eef
https://doi.org/10.1016/0027-5107(82)90147-6

Mutagenicity and DNA-excision repair induced by isoniazid after metabolic activation by isolated human and rat hepatocytes

Autor: Sing Hiem Yap, J.M. Neis, P.J.L. van Gemert, B.W. te Brömmelstroet, Hennie M.J. Roelofs, P.Th. Henderson

Publikováno v: Cancer letters. 30(1)

The mutagenic potency of isoniazid (INH) (a widely used antitubercular drug) towards Salmonella typhimurium strain hisG46 was studied in the Salmonella/hepatocyte suspension-assay, comprising isolated human or rat hepatocytes as metabolic system. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d225ad3226c0b92521844c3baa1b019c
https://pubmed.ncbi.nlm.nih.gov/3510717