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Akademický článek
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Autor:
Y.H.M. van Erp, P.J.J.M. Weterings
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 4(4-5)
A screening method was applied to determine the eye irritation potential of industrial chemicals. Bovine eyes (BE) were used to predict corneal damage and chicken egg chorioallantoic membranes (CAM) to estimate the irritancy potential of chemical sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::049ef94bd630b4dcc6eb5fb233ed16ae
https://pubmed.ncbi.nlm.nih.gov/20702175
https://pubmed.ncbi.nlm.nih.gov/20702175
Publikováno v:
Mutation Research/Environmental Mutagenesis and Related Subjects. 252:45-50
A method is described to investigate the induction of micronuclei in cultured human keratinocytes after short-term exposure to known clastogenic agents. The cytokinesis-block method was applied to facilitate the scoring of micronucleated cells. Mitom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::079f036a4f05d344d772eb44aa8ad222
https://doi.org/10.1016/0165-1161(91)90250-c
https://doi.org/10.1016/0165-1161(91)90250-c
Publikováno v:
Toxicology in Vitro. 5:515-518
Micronucleus formation in cultured human keratinocytes was studied after exposure to benzo[a]pyrene, cyclophosphamide and 12-O-tetradecanoylphorbol-13-acetate without the addition of an exogenous metabolizing system. The first two agents need bioacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69f1303e94fb7f2cba7bb6cb0bdbf903
https://doi.org/10.1016/0887-2333(91)90084-q
https://doi.org/10.1016/0887-2333(91)90084-q
Publikováno v:
Journal of Histochemistry & Cytochemistry. 38:1847-1851
We used specific monoclonal antibodies (MAb) to human cytochrome P450 isoenzymes to determine the presence of these proteins in human epidermal cells. Two MAb (P450-5 and P450-8) recognize major forms of hepatic cytochrome P450 involved in biotransfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c256dad73c7c194e85ec9573b8dc3cc
https://doi.org/10.1177/38.12.2254648
https://doi.org/10.1177/38.12.2254648
Autor:
Petra R.C.M. Heirbaut, Jan C.M. van der Hoeven, Marion J.E. Koopmans, Yvette H.M. van Erp, P.J.J.M. Weterings
Publikováno v:
Mutation research. 271(3)
A new method is described to investigate unscheduled DNA synthesis (UDS) in human tissue after exposure in vitro: the human hair follicle. A histological technique was applied to assess cytotoxicity and UDS in the same hair follicle cells. UDS induct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2976b0527059005dc502e52ca30633d1
https://pubmed.ncbi.nlm.nih.gov/1378192
https://pubmed.ncbi.nlm.nih.gov/1378192
Publikováno v:
Virchows Archiv B Cell Pathology Including Molecular Pathology. 45:255-266
The morphology of human scalp hair follicle keratinocytes, cultured on the bovine eye lens capsule, is studied by light and electron microscopy. The hair follicle keratinocytes in the stratified cultures are characterized by the presence of numerous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2963829860b351ee0197125ab421201b
https://doi.org/10.1007/bf02889868
https://doi.org/10.1007/bf02889868
Autor:
Hans Bloemendal, M.A. Kibbelaar, P.J.J.M. Weterings, Johannes A. Lenstra, Alphons J.M. Vermorken
Publikováno v:
FEBS Letters. 127:105-108
of the dry weight of hair, and which is insoluble in aqueous salt solutions. The water-soluble components of the hair have been generally neglected. In the^ hair follicle, -1% of the protein is water-soluble [3]. A new, simple method for hair protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c76c5fec5d7bdfb0bd06b4fec621a0eb
https://doi.org/10.1016/0014-5793(81)80352-3
https://doi.org/10.1016/0014-5793(81)80352-3
Publikováno v:
British Journal of Dermatology. 104:1-5
For the first time a method for culturing human hair follicle cells is described. The bovine eye lens capsule, a basement membrane-like structure, is used as the substrate for the cultures. In a culture medium supplemented with hydrocortisone and ins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39ebd276e40d9244d33ed17bddcfe5a1
https://doi.org/10.1111/j.1365-2133.1981.tb01704.x
https://doi.org/10.1111/j.1365-2133.1981.tb01704.x