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Lipocalin-2 contributes to experimental atherosclerosis in a stage-dependent manner

Autor: P.J. van Santbrink, Mara J. Kröner, Hidde Douna, Paul H.A. Quax, G.H.M. van Puijvelde, Johan Kuiper, Ilze Bot, Frank H. Schaftenaar, Jacob Amersfoort

Publikováno v: Atherosclerosis, 275, 214-224
Atherosclerosis

Lipocalin-2 (Lcn2) is a glycoprotein which can be secreted by immune cells. Several studies in humans have suggested Lcn2 can be used as a biomarker for the detection of unstable atherosclerotic lesions, partly as it is known to interact with MMP-9.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25d9f8df004667cac738a6f1b15723cb
http://hdl.handle.net/1887/66066

Leukocyte cathepsin S is a potent regulator of both cell and matrix turnover in advanced atherosclerosis

Autor: E. E. van der Wall, Th.J.C. van Berkel, R de Nooijer, P.J. van Santbrink, R. Dorland, Marijke M. Westra, Guo-Ping Shi, J.H. von der Thüsen, E.A.L. Biessen, Herman S. Overkleeft, A.O. Kraaijeveld, S.H. van Heiningen, Michiel A. Leeuwenburgh, Joop Jukema, Petri T. Kovanen, Ilze Bot

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology, 29(2), 188-194. Lippincott Williams and Wilkins
Arteriosclerosis, thrombosis and vascular biology, 29(2), 188-194. Lippincott Williams & Wilkins

Objective— A dysbalance of proteases and their inhibitors is instrumental in remodeling of atherosclerotic plaques. One of the proteases implicated in matrix degradation is cathepsin-S (CatS). To address its role in advanced lesion composition, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1cfdd062ab4c67cd41bb96da9d0d7f9
https://doi.org/10.1161/atvbaha.108.181578

An Unexpected Intriguing Effect of Toll-Like Receptor Regulator RP105 (CD180) on Atherosclerosis Formation With Alterations on B-Cell Activation

Autor: Christoph J. Binder, P.J. van Santbrink, Joop Jukema, Ziad Mallat, J.C. Karper, Ilze Bot, Johan Kuiper, Paul H.A. Quax, M.R. de Vries, M.M. Ewing, Anke Redeker, Ramon Arens, S.C.A. de Jager

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology, 33(12), 2810-2817

Objective— In atherosclerosis, Toll-like receptors (TLRs) are traditionally linked to effects on tissue macrophages or foam cells. RP105, a structural TLR4 homolog, is an important regulator of TLR signaling. The effects of RP105 on TLR signaling v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::666eef2cb3a6aa9ef8565718d5558f96
http://hdl.handle.net/1887/102251

Oxldl-induced apoptotic dendritic cells as a novel therapy for atherosclerosis

Autor: G.H.M. van Puijvelde, Ilze Bot, P.J. van Santbrink, S.C.A. de Jager, Vanessa Frodermann, Amanda C. Foks, J. Kuiper, H.M. Lagraauw, Laura Wierts

Publikováno v: Atherosclerosis. 241:e7

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::894f451a12326896ae64c9468aaa047d
https://doi.org/10.1016/j.atherosclerosis.2015.04.043