Zobrazeno 1 - 10 of 373 pro vyhledávání: '"P.J. Talmud"'
1
Akademický článek
Plasma levels of remnant particles are determined in part by variation in the APOC3 gene insulin response element and the APOCI–APOE cluster
Autor: D.M. Waterworth, J.A. Hubacek, J. Pitha, J. Kovar, R. Poledne, S.E. Humphries, P.J. Talmud
Publikováno v: Journal of Lipid Research, Vol 41, Iss 7, Pp 1103-1109 (2000)
Remnant particles of triglyceride-rich lipoproteins (RLP) are known to be a strong predictor of atherogenicity. The serum concentrations of remnant-like particle triglyceride (RLPTG) and remnant-like particle cholesterol (RLPC) have been determined i
Externí odkaz: https://doaj.org/article/750517433a6e46ddbf96c7f571663fea
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2
Akademický článek
Genotypic associations of the hepatic secretion of VLDL apolipoprotein B-100 in obesity
Autor: G.F. Watts, F.M. Riches, S.E. Humphries, P.J. Talmud, F.M. van Bockxmeer
Publikováno v: Journal of Lipid Research, Vol 41, Iss 3, Pp 481-488 (2000)
Abstract: We examined the effect of genetic polymorphisms of proteins regulating intrahepatic processing of apolipoprotein B-100 (apoB) and the supply of neutral lipids to the liver on the hepatic secretion of very low density lipoprotein (VLDL) apoB
Externí odkaz: https://doaj.org/article/2d16b85b019b4fa0bf10f49879c8657b
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3
Akademický článek
Apolipoprotein B signal peptide and apolipoprotein E genotypes as determinants of the hepatic secretion of VLDL apoB in obese men
Autor: F.M. Riches, G.F. Watts, F.M. van Bockxmeer, J. Hua, S. Song, S.E. Humphries, P.J. Talmud
Publikováno v: Journal of Lipid Research, Vol 39, Iss 9, Pp 1752-1758 (1998)
We aimed to examine the effect of genetic polymorphisms of apolipoprotein B-100 (apoB) signal peptide and apolipoprotein E (apoE) on the hepatic secretion of very low density lipoprotein (VLDL) apoB in 29 men with visceral obesity. We studied apoB se
Externí odkaz: https://doaj.org/article/6d00fcd9ba2f464b99ea63832bc7aa36
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4
Telomere shortening over 6 years is associated with increased subclinical carotid vascular damage and worse cardiovascular prognosis in the general population
Autor: Elena Tragni, Giuseppe Danilo Norata, Katia Garlaschelli, P.J. Talmud, Jutta Palmen, Alberico L. Catapano, Liliana Grigore, Andrea Baragetti, Fabio Pellegatta, S. E. Humphries
Publikováno v: Journal of Internal Medicine. 277:478-487
Introduction Leucocyte telomere length (LTL) is an important determinant of telomere function and cellular replicative capacity. The aim of the present study was to examine prospectively the associations between telomere shortening (TS) and both the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247b45e7c9348e5ac482e1f9335bfff9
https://doi.org/10.1111/joim.12282
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5
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis
Autor: John Connolly, John C. Whittaker, Helen Ireland, Hynek Pikhart, Olaf H. Klungel, Claudia Langenberg, Juan P. Casas, Y. van der Graaf, Anne Peasey, Emelia J. Benjamin, Meena Kumari, Nicholas J. Timpson, Růžena Kubínová, P.J. Talmud, Nita G. Forouhi, Verschuren Wmm., KaWah Li, Engmann Jel., C Chung, Tina Shah, Damiano Baldassarre, Mika Kivimäki, Eric J. Brunner, John Hardy, Karoline Kuchenbaecker, Charles B. Eaton, Y. T. van der Schouw, Michael V. Holmes, S. J. Bielinski, Jaroslav A. Hubacek, P. A. Doevendans, Susan Redline, Berta Almoguera Castillo, Westendorp Rgj., Reecha Sofat, Yiran Guo, Leslie A. Lange, Debbie A Lawlor, James G. Wilson, John Gallacher, Richard S. Houlston, Martin Bobak, Maarten Leusink, Andrzej Pajak, George Davey Smith, James F. Meschia, Peter H. Whincup, Rebecca Hardy, Michael Marmot, Jeffrey W. Stephens, Brendan J. Keating, Diana Kuh, Delaney Jac., Mikhail I. Voevoda, N. C. Onland-Moret, Timothy M. Frayling, Hakon Hakonarson, S Bandenelli, Frank Dudbridge, G Jan de Borst, F G Fowkes, Migle Baceviciene, Gordon D.O. Lowe, Gerjan Navis, Alexander P. Reiner, Simon P. Mooijaart, Phil Howard, Boer Jma., Stephen E. Epstein, A. de Boer, Ian Ford, U de Faire, Abdonas Tamosiunas, Malcolm G. Dunlop, AB Singleton, Nicholas J. Wareham, Renate B. Schnabel, Johan Wouter Jukema, Naveed Sattar, Folkert W. Asselbergs, Fotios Drenos, Jutta Palmen, Christina L. Wassel, Sofia Malyutina, Daniel I. Swerdlow, Tetsu Tanaka, Ron T. Gansevoort, Julian Peto, Jenna Price, Bakker Sjl., Ian Tomlinson, Yun Li, Bengt Sennblad, Jackie A. Cooper, Jian'an Luan, Aroon D. Hingorani, JoAnn E. Manson, Roman Pfister, Mailand-van der Zee A-H., I. Mateo Leach, Anders Hamsten, Mike A. Nalls, Yoav Ben-Shlomo, Richard W Morris, Joe Devaney, Marlene C. W. Stewart, P A de Jong, Steve E. Humphries, Roman Topor-Madry, P. van der Harst, Jennifer G. Robinson, Andrew Wong, Luigi Ferrucci, Elena Tremoli, Ioanna Tzoulaki, Mary-Susan Burnett
Publikováno v: The Lancet
The Lancet, 379(9822), 1214-1224. ELSEVIER SCIENCE INC
Hingorani, A D, Casas, J P, Price, J, Stewart, M & Dunlop, M & Tomlinson, I 2012, ' The interleukin-6 receptor as a target for prevention of coronary heart disease : a mendelian randomisation analysis ', The Lancet, vol. 379, no. 9822, pp. 1214-24 . https://doi.org/10.1016/S0140-6736(12)60110-X
The Lancet, 379(9822), 1214-1224. Elsevier Limited
Swerdlow, D I, Holmes, M V, Kuchenbaecker, K B, Engmann, J E L, Shah, T, Sofat, R, Guo, Y, Chung, C, Peasey, A & Timpson, N J & Casas, J P 2013, ' The interleukin-6 receptor as a target for prevention of coronary heart disease : a mendelian randomisation analysis ', Lancet, vol. 379, no. 9822, pp. 1214-1224 . https://doi.org/10.1016/S0140-6736(12)60110-X
The Lancet; Vol 379
SummaryBackgroundA high circulating concentration of interleukin 6 is associated with increased risk of coronary heart disease. Blockade of the interleukin-6 receptor (IL6R) with a monoclonal antibody (tocilizumab) licensed for treatment of rheumatoi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60303f253dccdcfa3075f1ed04fc1362
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6
Genetic Analysis of NR0B1 in Congenital Adrenal Hypoplasia Patients: Identification of a Rare Regulatory Variant Resulting in Congenital Adrenal Hypoplasia and Hypogonadal Hypogonadism without Testicular Carcinoma in situ
Autor: Pierre-Marc Bouloux, Robert C. Fowkes, Victoria Cabrera-Sharp, P. Wilkinson, Leendert H. J. Looijenga, P.J. Talmud, Ann P. Walker, Serra Kim, Steve E. Humphries, F. Saleh
Publikováno v: Sexual Development. 6:284-291
There have been few testicular histology reports of adult patients with congenital adrenal hypoplasia/hypogonadal hypogonadism (AHC/HH), but Leydig cell hyperplasia has been observed, an indicator of the possibility of malignant transformation. We ai
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::96ade98dd4025fee21376b0edd9d6356
https://doi.org/10.1159/000342295
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7
Variants of ADRA2A are associated with fasting glucose, blood pressure, body mass index and type 2 diabetes risk: meta-analysis of four prospective studies
Autor: Ian N. M. Day, Tina Shah, Meena Kumari, P.J. Talmud, Tom R. Gaunt, Debbie A Lawlor, Sonia Shah, Mika Kivimäki, Fotios Drenos, Aroon D. Hingorani, John C. Whittaker, J.A. Cooper, Michael V. Holmes, Juan P. Casas, Jutta Palmen, Steve E. Humphries
Publikováno v: Diabetologia
Aims/hypothesis We quantified the effect of ADRA2A (encoding α-2 adrenergic receptor) variants on metabolic traits and type 2 diabetes risk, as reported in four studies. Methods Genotype data for ADRA2A single nucleotide polymorphisms (SNPs) rs55366
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::140a758cd825f7361a3af628e711f674
https://doi.org/10.1007/s00125-011-2108-6
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8
Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding
Autor: A Dichlberger, Melchior C. Nierman, W.-W. Zeng, Martin Merkel, Jaroslav A. Hubacek, N Delsaux, R. Whittall, P J Lee, Laurence Lins, J. A. Kuivenhoven, B. Dorfmeister, P.J. Talmud, Stefan K. Nilsson, F G Schaap, John J.P. Kastelein, Wendy Putt, Gunilla Olivecrona, Michal Vrablík, Steve E. Humphries, Aivar Lookene, J.A. Cooper, W J Schneider, Joerg Heeren
Publikováno v: Arteriosclerosis, thrombosis, and vascular biology, 28(10), 1866-1871. Lippincott Williams and Wilkins
Objective— The purpose of this study was to identify rare APOA5 variants in 130 severe hypertriglyceridemic patients by sequencing, and to test their functionality, since no patient recall was possible. Methods and Results— We studied the impact
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26ed7eca2afc91b33a97144ee4257621
https://doi.org/10.1161/atvbaha.108.172866
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10
APOE polymorphism, socioeconomic status and cognitive function in mid-life
Autor: J H Zhao, Archana Singh-Manoux, P.J. Talmud, Eric J. Brunner, Michael Marmot, Meena Kumari, Emma Hawe, Steve E. Humphries
Publikováno v: Social Psychiatry and Psychiatric Epidemiology
Social Psychiatry and Psychiatric Epidemiology, Springer Verlag, 2005, 40 (7), pp.557-63. <10.1007/s00127-005-0925-y>
International audience; The aim of this study was to investigate the association of the common apolipoprotein E gene (APOE) variants with cognitive function and cognitive decline in adult mid-life and explore the possibility that APOE genotype mediat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::146f4cd6b68e1bfe0cad315690a8f035
https://doi.org/10.1007/s00127-005-0925-y
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