Zobrazeno 1 - 10 of 159 pro vyhledávání: '"P.J. Pauwels"'
1
Heterogeneous ligand-mediated Ca++ responses at wt and mutant α2A-adrenoceptors suggest multiple ligand activation binding sites at the α2A-adrenoceptor
Autor: P.J Pauwels, F.C Colpaert
Publikováno v: Neuropharmacology. 39:2101-2111
Ligand:receptor interactions were analysed at wild-type, Asp(79)Asn and Thr(373)Lys alpha(2A) AR by measuring Ca(++) responses in the co-presence of a G(alpha 15) protein in CHO-K1 cells. (-)-Adrenaline displayed a time-dependent Ca(++) response with
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e69e3ddacc2ed61f9e477c605e050f2c
https://doi.org/10.1016/s0028-3908(00)00040-x
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3
Modulation of Metallothionein-III mRNA Content and Growth Rate of Rat C6-Glial Cells by Transfection with Human 5-HT1D Receptor Genes
Autor: M.C. Amoureux, T. Wurch, P.J. Pauwels
Publikováno v: Biochemical and Biophysical Research Communications. 214:639-645
The mRNA content of the brain-specific metallothionein-III (MT-III) protein was measured by quantitative reverse transcription-polymerase chain reaction (RT-PCR) in two transformed glial cell lines: rat C6-glial and human U-373 MG cells. Low levels o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::988adbc568e971c13fd7f89855cf9de8
https://doi.org/10.1006/bbrc.1995.2334
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4
Inhibition by 5-HT of forskolin-induced cAMP Formation in the renal opossum Epithelial cell line OK: Mediation by a 5-HT1B like receptor and antagonism by methiothepin
Autor: P.J. Pauwels, C. Palmier
Publikováno v: Neuropharmacology. 33:67-75
The functional activity of various 5-HT receptor agonists, including 5-CT, sumatriptan, CP 93, 129 and 1-naphtylpiperazine, and of drugs known to bind with high affinity to 5-HT 1B (pindolol, propranolol, cyanopindolol, SDZ 21,009 and isamoltane) or
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247fe11352acb2c11303dc74380f788b
https://doi.org/10.1016/0028-3908(94)90098-1
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5
The 5-HT1Dreceptor antagonist GR 127,935 is an agonist at cloned human 5-HT1Dα receptor sites
Autor: P.J. Pauwels, F.C. Colpaert
Publikováno v: Neuropharmacology. 34:235-237
The cAMP response of the 5-HT1D receptor antagonist GR 127,935 was compared with 5-CT and ketanserin at cloned human 5-HT1Dα receptor sites in transfected C6-glial cells. GR 127,935 showed marked agonist activity (EC50-value: 141 nM), its maximal ef
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f6a54c79c48f3f7951a880972f7aa21
https://doi.org/10.1016/0028-3908(95)00007-s
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6
Sign-reversal during persistent activation in mu-opioid signal transduction
Autor: L.A. Bruins Slot, Francis Colpaert, P.J. Pauwels
Publikováno v: Journal of theoretical biology. 215(2)
A concept of signal transduction in biological systems specifies that any instantaneous input is appreciated by its departure from the moving average of past activity. The concept provides an adequate account of the occurrence of both the one-directi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1be0a67f95b06e0e61ea0c98b6e2a35
https://pubmed.ncbi.nlm.nih.gov/12051972
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7
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8
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