Zobrazeno 1 - 10
of 72
pro vyhledávání: '"P.H. Steenbergh"'
Autor:
Patrick Matthias, Sabine Gutzwiller, P.H. Steenbergh, Brigitte Fournier, Gabriele Matthias, Tanja Dittmar
Publikováno v:
Journal of Biological Chemistry. 276:35444-35449
The importance of insulin-like growth factor I (IGF-I) on maintenance of skeletal integrity has been widely recognized. Although osteoblasts secrete some IGF-I, the liver is the primary endocrine source for IGF-I. We have studied the regulation of th
Publikováno v:
FEBS Letters. 444:155-159
Salmon insulin-like growth factor-I (sIGF-I) expression is, as in mammals, induced by growth hormone (GH). To elucidate the mechanism by which GH stimulates the transcription of the IGF-I gene, we transiently transfected Hep3B cells expressing the ra
Autor:
Hetty A.A.M. van Teeffelen, Frederik M. A. van Schaik, Brigitte Dufourny, Bart van der Burg, P.H. Steenbergh, Jacqueline Alblas, John S. Sussenbach
Publikováno v:
Journal of Biological Chemistry. 272:31163-31171
Addition of insulin-like growth factor I (IGF-I) to quiescent breast tumor-derived MCF-7 cells causes stimulation of cyclin D1 synthesis, hyperphosphorylation of the retinoblastoma protein pRb, DNA synthesis, and cell division. All of these effects a
Publikováno v:
Molecular Endocrinology. 9:1488-1499
Expression of the human insulin-like growth factor I (hIGF-I) gene is regulated in a tissue- and developmental stage-specific manner. The hIGF-I gene has two promoters, P1 and P2. P1 is the more active promoter by far in adult liver, the main endocri
Publikováno v:
Molecular Endocrinology. 8:1636-1645
The expression of the human insulin-like growth factor I (hIGF-I) gene is regulated in a developmental stage- and tissue-specific manner. Postnatally, the liver becomes the main endocrine source of this important growth factor. The hIGF-I gene contai
Publikováno v:
Biochemical and Biophysical Research Communications. 175:507-514
IGF-I gene expression in mammals typically results in multiple mRNA species ranging in size between 0.7 and 7.6 kb. The smaller mRNA species have largely been characterized by the analysis of nearly full-length cDNAs. This report describes the first
Autor:
Richard F.M.A. van Schaik, Jorrit Sipkema, P.H. Steenbergh, Irene H.L. Hamelers, John S. Sussenbach
Publikováno v:
The Journal of biological chemistry. 277(49)
Stimulation of the breast cancer-derived MCF-7S cell line with insulin-like growth factor I (IGF-I; 20 ng/ml) leads to enhanced expression of cyclin D1, hyperphosphorylation of pRb, DNA synthesis, and cell division. 17beta-Estradiol (E(2); 10(-9) m)
Autor:
John S. Sussenbach, Richard F.M.A. van Schaik, Irene H.L. Hamelers, Hetty A.A.M. van Teeffelen, P.H. Steenbergh
Publikováno v:
Experimental cell research. 273(1)
We have analyzed the mechanism by which the combination of insulin-like growth factor I (IGF-I) and 17 β-estradiol (E2) induces cell cycle progression in MCF-7S cells. This cell line differs from many other breast cancer-derived cell lines in that E
Autor:
H. A. A. M. Van Teeffelen, P.H. Steenbergh, Irene H.L. Hamelers, B. Dufourny, John S. Sussenbach
Publikováno v:
The Journal of endocrinology. 166(2)
Treatment of quiescent MCF-7 human breast cancer cells with either the polypeptide growth factors insulin-like growth factor-I (IGF-I) or epidermal growth factor (EGF), the steroid hormone estradiol (E2) or the phorbol ester 12-O-tetradecanoylphorbol
Publikováno v:
The IGF System ISBN: 9781617371387
The insulin-like growth factors (IGFs) are potent mitogens for many different cell types and play a central role in growth and development. The significance of the IGFs in these processes has recently been shown by the dramatic effects of mutations i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65ec4840111f3ba8bfceca4f1aadf16b
https://doi.org/10.1007/978-1-59259-712-3_3
https://doi.org/10.1007/978-1-59259-712-3_3