Zobrazeno 1 - 10 of 83 pro vyhledávání: '"P.H. Smits"'
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Akademický článek
CRISPR-Cas9‒Based Genomic Engineering in Keratinocytes: From Technology to Application
Autor: Jos P.H. Smits, Luca D. Meesters, Berber G.W. Maste, Huiqing Zhou, Patrick L.J.M. Zeeuwen, Ellen H. van den Bogaard
Publikováno v: JID Innovations, Vol 2, Iss 2, Pp 100082- (2022)
CRISPR-Cas9 is the most straightforward genome-editing tool to date. However, its implementation across disciplines is hampered by variable genome-editing efficiencies, reduced cell viability, and low success rates in obtaining clonal cell lines. Thi
Externí odkaz: https://doaj.org/article/c3c753563989465a9f3d08814fe48ea5
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2
Lead optimization of aryl hydrocarbon receptor ligands for treatment of inflammatory skin disorders
Autor: Gijs Rikken, Kayla J. Smith, Noa J.M. van den Brink, Jos P.H. Smits, Krishne Gowda, Angela Alnemri, Gulsum E. Kuzu, Iain A. Murray, Jyh-Ming Lin, Jos G.A. Smits, Ivonne M. van Vlijmen-Willems, Shantu G. Amin, Gary H. Perdew, Ellen H. van den Bogaard
Publikováno v: Biochemical Pharmacology, 208
Therapeutic aryl hydrocarbon receptor (AHR) modulating agents gained attention in dermatology as non-steroidal anti-inflammatory drugs that improve skin barrier properties. By exploiting AHR's known ligand promiscuity, we generated novel AHR modulati
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7172d2666ec03b70eb38539132641e5
https://hdl.handle.net/2066/290126
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3
Targeting Skin Barrier Function in Atopic Dermatitis
Autor: Ellen H. van den Bogaard, Peter M. Elias, Elena Goleva, Evgeny Berdyshev, Jos P.H. Smits, Simon G. Danby, Michael J. Cork, Donald Y.M. Leung
Publikováno v: Journal of Allergy and Clinical Immunology. In Practice, 11, 5, pp. 1335-1346
Journal of Allergy and Clinical Immunology. In Practice, 11, 1335-1346
Item does not contain fulltext Atopic dermatitis (AD) is the most common chronic inflammatory skin disease in the general population. Skin barrier dysfunction is the central abnormality leading to AD. The cause of skin barrier dysfunction is complex
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2648f2445b96a63c0ba072d01fc5e361
https://repository.ubn.ru.nl/handle/2066/292717
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4
Akademický článek
Mutant p63 Affects Epidermal Cell Identity through Rewiring the Enhancer Landscape
Autor: Jieqiong Qu, Sabine E.J. Tanis, Jos P.H. Smits, Evelyn N. Kouwenhoven, Martin Oti, Ellen H. van den Bogaard, Colin Logie, Hendrik G. Stunnenberg, Hans van Bokhoven, Klaas W. Mulder, Huiqing Zhou
Publikováno v: Cell Reports, Vol 25, Iss 12, Pp 3490-3503.e4 (2018)
Summary: Transcription factor p63 is a key regulator of epidermal keratinocyte proliferation and differentiation. Mutations in the p63 DNA-binding domain are associated with ectrodactyly, ectodermal dysplasia, and cleft lip/palate (EEC) syndrome. How
Externí odkaz: https://doaj.org/article/6919d3e388824bdd9a978149c19f51f2
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5
Skin microbiota in health and disease: From sequencing to biology
Autor: Jos Boekhorst, Jos P.H. Smits, Joost Schalkwijk, Thomas H. A. Ederveen, Ellen H. van den Bogaard, Patrick L.J.M. Zeeuwen
Publikováno v: Journal of Dermatology, 47, 10, pp. 1110-1118
Journal of Dermatology, 47, 1110-1118
The Journal of Dermatology
Contains fulltext : 229323.pdf (Publisher’s version ) (Open Access) Microbiota live in a closely regulated interaction with their environment, and vice versa. The presence and absence of microbial entities is greatly influenced by features of the n
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc79e76d8a6f5a231e383cfce2f29121
https://hdl.handle.net/2066/229323
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6
Know your enemy: Unexpected, pervasive and persistent viral and bacterial contamination of primary cell cultures
Autor: Gijs Rikken, Patrick A. M. Jansen, Hanna Niehues, Ellen H. van den Bogaard, Jos P.H. Smits, Joost Schalkwijk, Patrick L.J.M. Zeeuwen, Diana Rodijk-Olthuis
Publikováno v: Experimental Dermatology, 29, 672-676
Experimental Dermatology
Experimental Dermatology, 29(7), 672-676
Experimental Dermatology 29 (2020) 7
Experimental Dermatology, 29, 7, pp. 672-676
Contains fulltext : 229256.pdf (Publisher’s version ) (Open Access) In biomedical research, cell culture contamination is one of the main culprits of experimental failure. Contamination sources and concomitant remedies are numerous and challenging
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::842d7e390a7cae8581b6e96a57b8a034
https://doi.org/10.1111/exd.14126
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7
Antimicrobial Late Cornified Envelope Proteins: The Psoriasis Risk Factor Deletion of LCE3B/C Genes Affects Microbiota Composition
Autor: Hanna Niehues, Danique A. van der Krieken, Thomas H.A. Ederveen, Patrick A.M. Jansen, Laura van Niftrik, Rob Mesman, Mihai G. Netea, Jos P.H. Smits, Joost Schalkwijk, Ellen H. van den Bogaard, Patrick L.J.M. Zeeuwen
Publikováno v: Journal of Investigative Dermatology, 142, 1947-1955.e6
Journal of Investigative Dermatology, 142, 7, pp. 1947-1955.e6
Contains fulltext : 251157.pdf (Publisher’s version ) (Open Access) Late cornified envelope proteins are predominantly expressed in the skin and other cornified epithelia. On the basis of sequence similarity, this 18-member homologous gene family h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eadbd1507be87a277a85a1edceebc5ed
http://hdl.handle.net/2066/251157
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9
CRISPR-Cas9‒Based Genomic Engineering in Keratinocytes: From Technology to Application
Autor: Ellen H. van den Bogaard, Berber G.W. Maste, Patrick L.J.M. Zeeuwen, Luca D. Meesters, Huiqing Zhou, Jos P.H. Smits
Publikováno v: JID Innovations, Vol 2, Iss 2, Pp 100082-(2022)
JID innovations, 2, 2
JID innovations, 2
Contains fulltext : 248251.pdf (Publisher’s version ) (Open Access) CRISPR-Cas9 is the most straightforward genome-editing tool to date. However, its implementation across disciplines is hampered by variable genome-editing efficiencies, reduced cel
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c087c76c90e50a35f624b3ec53fe00b
https://pubmed.ncbi.nlm.nih.gov/35146483
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10
Terminal keratinocyte differentiation in vitro is associated with a stable DNA methylome
Autor: Ellen H. van den Bogaard, Hendrik Marks, René A.M. Dirks, Merel A.W. Oortveld, Arie B. Brinkman, Patrick L.J.M. Zeeuwen, Jieqiong Qu, Jos P.H. Smits, Joost Schalkwijk, Huiqing Zhou
Publikováno v: Experimental Dermatology, 30, 8, pp. 1023-1032
Experimental Dermatology, 30, 1023-1032
Experimental Dermatology
The epidermal compartment of the skin is regenerated constantly by proliferation of epidermal keratinocytes. Differentiation of a subset of these keratinocytes allows the epidermis to retain its barrier properties. Regulation of keratinocyte fate—w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7490b1c38f428033458f7bd78e3d51fb
https://repository.ubn.ru.nl/handle/2066/235970
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