Výsledky vyhledávání - "P.H. Premaratne"

Natural immunogenic properties of bioinformatically predicted linear B-cell epitopes of dengue envelope and pre-membrane proteins

Autor: Chandima Jeewandara, Charitha L. Goonasekara, Mahesha N. Nadugala, Aravinda M. de Silva, P.H. Premaratne, Gathsaurie Neelika Malavige, Ramesh Jadi

Publikováno v: BMC Immunology, Vol 22, Iss 1, Pp 1-14 (2021)
BMC Immunology

Background The natural antibody responses to B-cell epitopes from dengue structural proteins were assessed using immune sera from people having well-defined past dengue infections with one of the four serotypes. Method Based on an immune-computationa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d73bd8212518c8084e7e80cfb5819f6a
https://doi.org/10.1186/s12865-021-00462-4

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Prevalence of cutaneous leishmaniasis infection and clinico-epidemiological patterns among military personnel in Mullaitivu and Kilinochchi districts of the Northern Province, early war-torn areas in Sri Lanka

Autor: Deepika Fernando, Saveen Semege, Nayana Gunathilaka, P.H. Premaratne, Lahiru Udayanga, H. D. Wijesinghe, N.H. Manamperi, Nishantha Pathirana

Publikováno v: Parasites & Vectors
Parasites & Vectors, Vol 13, Iss 1, Pp 1-12 (2020)

Background The 30-year-old armed conflict in Sri Lanka resulted in a general breakdown of civil administration in the Northern and Eastern provinces, leading to mobilisation of many armed forces personnel to assist with reconstruction and resettlemen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a09a2dce25211cf7bdc956eb1407fb
https://pubmed.ncbi.nlm.nih.gov/32430014

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Natural antibody responses to the capsid protein in sera of Dengue infected patients from Sri Lanka

Autor: Chandima Jeewandara, Charitha L. Goonasekara, Mahesha N. Nadugala, Gathsaurie Neelika Malavige, P.H. Premaratne

Publikováno v: PLoS ONE, Vol 12, Iss 6, p e0178009 (2017)
PLoS ONE

This study aims to characterize the antigenicity of the Capsid (C) protein and the human antibody responses to C protein from the four dengue virus (DENV) serotypes. Parker hydrophilicity prediction, Emini surface accessibility prediction and Karplus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4440496a25a6e07692f7e57a3c6dbc4f
http://europepmc.org/articles/PMC5459338?pdf=render

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Systematic Bioinformatic Approach for Prediction of Linear B-Cell Epitopes on Dengue E and prM Protein

Autor: Mahesha N. Nadugala, P.H. Premaratne, Charitha L. Goonasekara

Publikováno v: Advances in Bioinformatics
Advances in Bioinformatics, Vol 2016 (2016)

B-cell epitopes on the envelope (E) and premembrane (prM) proteins of dengue virus (DENV) were predicted using bioinformatics tools, BepiPred, Ellipro, and SVMTriP. Predicted epitopes, 32 and 17 for E and prM proteins, respectively, were then charact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dba88bcad7bddd13f8525912f344704
https://pubmed.ncbi.nlm.nih.gov/27688753

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Genetic complexity ofPlasmodium vivaxinfections in Sri Lanka, as reflected at the merozoite-surface-protein-3α locus

Autor: Shiroma M. Handunnetti, P.H. Premaratne, Thilan Wickramarachchi, Sajani Dias, Preethi V. Udagama-Randeniya

Publikováno v: Annals of Tropical Medicine & Parasitology. 104:95-108

The presence of genetically different strains of malarial parasites in cases of human malaria is a severe drawback in the successful control of the disease. In Sri Lanka, although this species accounts for 60%-80% of all of the cases of clinical mala

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5d3032e3820b08db1d7cf56e1f98c02
https://doi.org/10.1179/136485910x12607012374190

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Genetic Diversity and Selection at the Plasmodium vivax Apical Membrane Antigen-1 (PvAMA-1) Locus in a Sri Lankan Population

Autor: Dyann F. Wirth, Shiroma M. Handunnetti, Daniel L. Hartl, Thilan Wickramarachchi, Preethi V. Udagama-Randeniya, P.H. Premaratne, Anusha Gunasekera, Ishani Ganguli, Daniel E. Neafsey, Lakshman Perera

Publikováno v: Molecular Biology and Evolution. 24:939-947

Plasmodium vivax apical membrane antigen 1 (PvAMA-1) is an important malaria vaccine candidate. We present the first comprehensive analysis of nucleotide diversity across the entire PvAMA-1 gene using a single population sample from Sri Lanka. In con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5b2a2029fe6234434f9a3343074b06d
https://doi.org/10.1093/molbev/msm013

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A comparison of two tests for filarial antigenemia in areas in Sri Lanka and Indonesia with low-level persistence of lymphatic filariasis following mass drug administration

Autor: Femmy Pical, Peter Fischer, Thishan C. Yahathugoda, Melanie M. Lloyd, P.H. Premaratne, Gary J. Weil, Ramakrishna U. Rao, Taniawati Supali, Mirani V. Weerasooriya, Yenny Djuardi, Difa Stefani

Publikováno v: Parasites & Vectors

Background Filarial antigen tests are key tools for mapping the distribution of bancroftian filariasis and for detecting areas with persistent infections following mass drug administration (MDA). A recent study showed that the new Alere Filariasis Te

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8befafe248736e50b419e3009f2ab4e
http://europepmc.org/articles/PMC4501213

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Genetic diversity of Plasmodium vivax Duffy Binding Protein II (PvDBPII) under unstable transmission and low intensity malaria in Sri Lanka

Autor: B. Ramesh Aravinda, P.H. Premaratne, Preethi V. Udagama, Ananias A. Escalante

Publikováno v: Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. 11(6)

Elucidating the genetic diversity of the Duffy Binding Protein II (PvDBPII), a leading vaccine candidate for vivax malaria, in different geographical settings is vital. In Sri Lanka malaria transmission is unstable with low intensity. A relatively hi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c2a46f9135a61cca5be9366740a7a53
https://pubmed.ncbi.nlm.nih.gov/21554998

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Genetic diversity and the ensuing strain specific immunity to asexual erythrocytic stage vaccine candidate antigens, MSP-1, AMA-1 and DBP, of Plasmodium vivax in Sri Lanka

Autor: Thilan Wickramarachchi, Sajani Dias, P.H. Premaratne, Preethi V. Udagama-Randeniya

Publikováno v: Malaria Journal

Characterization of genetic diversity among locally prevalent parasite strains and the ensuing strain-specific immunity will be particularly important in a specific geographical setting for development of vaccine constructs and for planning future va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469d6d01b5647ab36ae6444ba1654853
https://doi.org/10.1186/1475-2875-9-s2-p55

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Natural Human Antibody Responses to Plasmodium vivax Apical Membrane Antigen 1 under Low Transmission and Unstable Malaria Conditions in Sri Lanka

Autor: P.H. Premaratne, Thilan Wickramarachchi, Preethi V. Udagama-Randeniya, Alan W. Thomas, Clemens H. M. Kocken, K. L. R. Lakshman Perera, Sumith Bandara, Shiroma M. Handunnetti

Plasmodium vivax apical membrane antigen 1, an important malaria vaccine candidate, was immunogenic during natural malaria infections in Sri Lanka, where low transmission and unstable malaria conditions prevail. Antibody prevalence increased with exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecdaa2e3ac929fbd684e90ba4d89c060
https://europepmc.org/articles/PMC1346644/

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