Zobrazeno 1 - 10
of 100
pro vyhledávání: '"P.H. Degen"'
Autor:
P.H. Degen, Sharif Mahsufi Mansor, V. Navaratnam, N.K. Nair, Norizah Yahaya, Walther H. Wernsdorfer
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 682:321-325
A rapid and selective high-performance liquid chromatographic assay for determination of a new antimalarial drug (benflumetol, BFL) is described. After extraction with hexane-diethyl ether (70:30, v/v) from plasma, BFL was analysed using a C18 Partis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda5d65af4f0b639a70d8951fa468dee
https://doi.org/10.1016/0378-4347(96)00086-2
https://doi.org/10.1016/0378-4347(96)00086-2
Autor:
P. Zbinden, P.H. Degen
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 681:339-345
A specific and sensitive liquid chromatographic assay for the determination of 4-amidino-1-indanone-2'-amidinohydrazone (CGP 48 664, I) and a potential metabolite, 2-(4-carbamoyl-2,3-dihydro-1H-inden-1-yliden) hydrazine carboximidamide (CGP 53 391, I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1d62df627dc300b4d7d737c8f2ab8d4
https://doi.org/10.1016/0378-4347(96)00026-6
https://doi.org/10.1016/0378-4347(96)00026-6
Publikováno v:
Biopharmaceutics & Drug Disposition. 16:603-614
A study was performed in ten patients, stabilized with oxcarbazepine monotherapy (450–750 mg bid) for two weeks minimum, to investigate the possibility of using saliva to monitor the oxcarbazepine therapy. Thirteen paired blood and saliva samples w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ac65f1c2718ac1a9e32acf854007d9c
https://doi.org/10.1002/bdd.2510160708
https://doi.org/10.1002/bdd.2510160708
Publikováno v:
Journal of Chromatography A. 623:191-195
A significantly improved method for the determination of the monoamine oxidase A inhibitor brofaromine hydrochloride and its major metabolite is described. A newly constructed multi-purpose injector for capillary column gas chromatography (cGC) was u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c4d01bfb1bd77131db207d06b299fc6
https://doi.org/10.1016/0021-9673(92)85318-n
https://doi.org/10.1016/0021-9673(92)85318-n
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 581:147-151
An enantioselective liquid chromatographic assay for the simultaneous determination of the S-(+) and R-(-) enantiomers of the monohydroxylated metabolite of oxcarbazepine in human plasma is described. The metabolite is the active principle. The metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e91a3f9d10e27df8eeb749997399e80
https://doi.org/10.1016/0378-4347(92)80459-4
https://doi.org/10.1016/0378-4347(92)80459-4
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 568:261-266
An improved method for the determination of 1-hydroxy-3-aminopropylidene-1,1-bisphosphonate (pamidronate) in human urine and plasma is described. The procedure is based on a co-precipitation of the bisphosphonates (pamidronate and 6-amino-1-hydroxype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb5e90400e6a0b4e3e5cb3c67c332302
https://doi.org/10.1016/0378-4347(91)80362-g
https://doi.org/10.1016/0378-4347(91)80362-g
Autor:
W. Schneider, P.H. Degen
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 565:67-73
A sensitive and specific quantitative assay has been developed for the determination of 4-hydroxyandrostenedione (4-OHA), a potent aromatase inhibitor used in the treatment of estrogen-dependent breast cancer. This steroid has a high first-pass metab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b2753075b8b6967754a12430db14a70
https://doi.org/10.1016/0378-4347(91)80371-i
https://doi.org/10.1016/0378-4347(91)80371-i
Publikováno v:
Journal of chromatography. B, Biomedical sciences and applications. 696(1)
A liquid chromatographic assay for the determination of CGP 61755 (I) in plasma and urine is described. A similar method for CGP 53437, another HIV-1 protease inhibitor, has been developed and reported previously. After a deproteinization step, a liq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feafa5892a87658d90c286180850935c
https://pubmed.ncbi.nlm.nih.gov/9300916
https://pubmed.ncbi.nlm.nih.gov/9300916
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 15(12)
Zoledronate, 2-(imidazole-1-yl)-1-hydroxyethane-1,1-bisphosphonic acid is a new 3rd generation bisphosphonate. A specific enzyme inhibition assay was developed for the determination of zoledronate in plasma of animals and man. The multistep synthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8e2aad3fb3d93bb44c50b93150ed469
https://pubmed.ncbi.nlm.nih.gov/9278893
https://pubmed.ncbi.nlm.nih.gov/9278893
Publikováno v:
Biopharmaceuticsdrug disposition. 15(6)
The effect of food on the pharmacokinetics of the antiepileptic oxcarbazepine (OXC) was investigated in healthy volunteers. Six healthy male volunteers were treated with single peroral doses of 600 mg of oxcarbazepine (Trileptal) after overnight fast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6b3e945706db2310fbbed5334524c75
https://pubmed.ncbi.nlm.nih.gov/7993989
https://pubmed.ncbi.nlm.nih.gov/7993989