Zobrazeno 1 - 10
of 113
pro vyhledávání: '"P.G. Watanabe"'
Autor:
William Stansley, P.G. Watanabe, Molly Whitworth, Christine M. Bunck, Crystal J. Driver, Thomas E. Lacher, Frederick A. Leighton, Bernard Daniel, Christian E. Grue, Ronald J. Kendall
Publikováno v:
Environmental Toxicology and Chemistry. 15:4-20
There is increasing concern that birds in terrestrial ecosystems may be exposed to spent lead shot. Evidence exists that upland birds, particularly mourning doves (Zenaida macroura), ingest spent lead shot and that raptors ingest lead shot by consumi
Autor:
P.G. Watanabe, R.P. Sharma
Publikováno v:
Journal of Comparative Pathology. 85:373-381
A mixed cell nerve tissue culture system from dorsal root ganglia of chick embryos was used to test the effects of tri- o -tolyl phosphate (TOTP), its metabolites and di-isopropylphosphorofluoridate (DFP). Cytotoxic responses consisted of reduction i
Publikováno v:
Toxicology and Applied Pharmacology. 62:137-151
Male B6C3F1 mice metabolized inhaled trichloroethylene (TRI) (600 ppm/6 hr) to a greater extent (262% more) than male Osborne-Mendel rats. Mice metabolized more (332%) inhaled TRI to a hepatic macromolecular binding metabolite in vivo than rats. Oral
Autor:
J.F. Quast, Tony R. Fox, Patrick W. Langvardt, P.G. Watanabe, John C. Ramsey, Richard H. Reitz
Publikováno v:
Toxicology and Applied Pharmacology. 62:190-204
Ethylene dichloride (EDC) induces tumors in rats and mice when administered chronically by gavage. However, chronic inhalation of EDC vapor failed to induce any treatment-related tumors. To help understand the consequences of environmental exposure t
Publikováno v:
Toxicology and Applied Pharmacology. 34:529-532
Percutaneous absorption of 14c-labeled vinyl chloride (VC) was examined in male rhesus monkeys. Two monkeys were exposed (whole body, excluding the head) to atmospheres containing 7000 and 800 ppm of VC for 2.0 and 2.5 hr, respectively. The amount of
Publikováno v:
Toxicology and Applied Pharmacology. 44:571-579
Covalent binding of radioactivity to hepatic macromolecules in rats exposed to 14C-labeled vinyl chloride (VC) was studied to determine if VC-induced carcinogenesis may be related to electrophilic alkylation of macromolecules in vivo. Male Sprague-Da
Publikováno v:
Journal of Labelled Compounds. 11:535-542
A modification of our previously reported2 gas chromatographic method of preparing vinyl-14C2 chloride (14C-VC) has been made. The procedure using 1,2-dichloroethane-14C2 obtained from New England Nuclear Corporation gave good yields of 14C-VC as a g
Publikováno v:
Annals of the New York Academy of Sciences. 329:137-152
Publikováno v:
Annals of the New York Academy of Sciences. 246:135-148
Autor:
P.G. Watanabe, W.T. Stott
Publikováno v:
Toxicology and Applied Pharmacology. 55:411-416
The possibility that chemicals which are mutagenic in in vitro assays pose a “hidden” threat to humans as mutagens has been suggested. Yet, such in vitro studies do not reflect whole animal defense mechanisms against mutation. Therefore, the effe