Zobrazeno 1 - 10
of 60
pro vyhledávání: '"P.F. Wadsworth"'
Publikováno v:
Carcinogenesis. 17:973-981
Liver enlargement is a common feature of non-genotoxic rodent hepatocarcinogens administered at high doses. In the present study, the expression of growth factors and growth factor receptors was investigated in the C57BL/1OJ mouse during liver enlarg
Publikováno v:
Scopus-Elsevier
Summary Neuron-specific enolase (NSE) was found to he consistently present in the rat and mouse adrenal medulla in the normal and neoplastic state. It is suggested that NSE immunoreactivity may be a useful tool in the differential diagnosis of phaeoc
Autor:
P.F. Wadsworth, D.M. Jones
Publikováno v:
Avian Pathology. 10:95-99
Summary An ovarian adenocarcinoma was diagnosed in a greater flamingo (Phoeni‐copterus ruber roseus) which had been maintained in captivity for over 32 years. Neoplastic epithelial cells showed both solid and tubular patterns of growth. Metastases
Autor:
P.F. Wadsworth, R. Heywood
Publikováno v:
Toxicology Letters. 2:115-118
Diethylstilboestrol (DES) was administered parenterally to a group of four pregnant rhesus monkeys at the dose level of 1 mg/kg/day from day 45 of gestation until parturition. Two monkeys aborted, but two infant monkeys, one male and one female, were
Publikováno v:
Contraception. 20:339-351
The effects of both progesterone- and norethisterone-loaded intravaginal rings were investigated in twenty-five rhesus monkeys for 52 weeks. The intravaginal rings were designed to provide a sustained release of either the human dosage level of the h
Publikováno v:
Toxicology. 7:357-365
When methyl testosterone was administered orally to beagle dogs at dosage levels of 2, 4 and 6 mg/kg per day for 27 weeks, hepatotoxicity was induced. The change induced was characterized by enlargement of periportal hepatocytes and the presence of h
Autor:
P.F. Wadsworth, R. Heywood
Publikováno v:
Pharmacology & Therapeutics. 8:125-142
Publikováno v:
Contraception. 20:177-184
The effects of levonorgestrel-loaded plastic intrauterine devices on endometrial morphology were investigated in 15 rhesus monkeys for 14 weeks. The devices were designed to release 25 μg of the hormone per day and were inserted in the uterus by hys
Publikováno v:
Contraception. 20:559-567
The effects of levonorgestrel-releasing intravaginal rings were investigated in 15 rhesus monkeys for 52 weeks. The intravaginal rings were designed to provide a sustained release of either three or ten times the human dose level of the hormone. Untr
Publikováno v:
Toxicology Letters. 1:169-174
Administration of ethinyl estradiol to the female rhesus monkey at a dosage level of 100 μug/kg/day for 26 weeks resulted in elevation of serum alanine aminotransferase (SALT) and LAP values. Light microscopy showed no morphological change, but by e