Zobrazeno 1 - 10
of 45
pro vyhledávání: '"P.A.E.L. Schilderman"'
Autor:
L.M. Maas, T.M.C.M. de Kok, P.A.E.L. Schilderman, D. M. F. A. Pachen, F.J. van Schooten, Jos C. S. Kleinjans
Publikováno v:
Environmental and Molecular Mutagenesis, 36, 79-86. Wiley
It is known that lower-chlorinated biphenyls are metabolically activated to electrophilic quinoid species capable of binding to DNA. Also, certain metabolites are capable of redox cycling, thereby increasing oxidative stress in biological systems. In
Autor:
P.A.E.L. Schilderman, Wendy M.R. Broekmans, Frederik J. van Schooten, Edwin J.C. Moonen, Jos C. S. Kleinjans, Roger W. L. Godschalk
Publikováno v:
Carcinogenesis, 1, 21, 87-92
Carcinogenesis, 21, 87-92. Oxford University Press
Carcinogenesis, 21, 87-92. Oxford University Press
Understanding the kinetics of aromatic-DNA adducts in target tissues and white blood cells (WBC) would enhance the applicability of DNA adducts in WBC as surrogate source of DNA in biomonitoring studies. In the present study, rats were acutely expose
Autor:
Jos C. S. Kleinjans, P.A.E.L. Schilderman, Jos M.A de Jong, Irene J Welle, John J.M. Engelen, Ivo H. Zwingmann
Publikováno v:
Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis, 431(2), 361-369. Elsevier
Department of Health Risk Analysis and Toxicology, Maastricht University, Netherlands.Various markers of radiation-induced DNA damage including DNA oxidation were investigated in peripheral lymphocytes of 23 cancer patients prior to and one week afte
Publikováno v:
Ecotoxicology and Environmental Safety. 44:241-252
The river Meuse, located in western Europe, is contaminated by different pollutants, of both organic and inorganic nature. The predominant sources of Meuse contamination in The Netherlands are agricultural activities and pollution derived from urban
Autor:
Paul J. A. Borm, Peter Nehls, P.A.E.L. Schilderman, Roel P. F. Schins, Joachim Bruch, Frank Seiler, Ad M. Knaapen
Publikováno v:
Free Radical Biology and Medicine, 27(1-2), 234-240. Elsevier Science
Department of Health Risk Analysis and Toxicology, Maastricht University, The Netherlands.Inflammation has been recognized as a contributing factor in the pathogenesis of some cancers. In the lung, inflammation is characterized by an influx of polymo
Autor:
John J.M. Engelen, Ivo H. Zwingmann, M.H.M. van Herwijnen, Tj. Smid, I.J. Welle, P.A.E.L. Schilderman, Jos C. S. Kleinjans
Publikováno v:
Environmental and Molecular Mutagenesis, 32(2), 121-129. Wiley
Department of Health Risk Analysis and Toxicology, Maastricht University, The Netherlands.j.kleinjans@GRAT.unimaas.nlThis study set out to analyze biomarkers for genotoxic events, e.g., oxidative DNA damage, chromosomal damage and hprt mutations, amo
Autor:
Edwin J.C. Moonen, Frederik-Jan van Schooten, P.A.E.L. Schilderman, I.T.M. Vermeer, E. Kriek, Roger W. L. Godschalk, Jos C. S. Kleinjans, B.G.J. Floot
Publikováno v:
Chemico-Biological Interactions. 104:41-54
DNA adduct analysis is often used for biomonitoring individuals exposed to polycyclic aromatic hydrocarbons (PAH). The 32P-postlabeling assay is routinely applied to study the formation of aromatic bulky adducts, but cannot positively identify indivi
Autor:
J. H. Van Wijnen, L.M. Maas, B.J.H. van Os, F.J. van Schooten, Edwin J.C. Moonen, P.A.E.L. Schilderman, J. A. Hoogewerff, J.C.S. Kleinjans
Publikováno v:
Environmental Health Perspectives
Scopus-Elsevier
Scopus-Elsevier
Wild city pigeons were caught at four different locations in the Netherlands to represent areas of high (Amsterdam-high), moderate (Amsterdam-medium), and low (Maastricht and Assen) traffic density. It is assumed that local ambient air pollution decr
Publikováno v:
Environmental Health Perspectives
During the last few decades, the industrial production and use of Cd resulted in the release of significant quantities of Cd into the environment. Concern about health risks of human exposure to this toxic metal, which may be contained in soil and ot
Autor:
F.J. ten Vaarwerk, J.T. Lutgerink, J.C.S. Kleinjans, F. ten Hoor, A. Van Der Wurff, P.A.E.L. Schilderman
Publikováno v:
Food and Chemical Toxicology. 33:99-109
The effect of metabolic activation of the food additive 3-tert-butyl-4-hydroxyanisole (BHA) by prostaglandin H synthase on the gastro-intestinal cell proliferation was determined by studies of the nature and the time dependency of early lesions in th