Výsledky vyhledávání - "P.A. Schubiger"

Versatile synthetic approach to new bifunctional chelating agents tailor made for labeling with the fac-[M(CO)3]+ core (M = Tc, 99mTc, Re): synthesis, in vitro, and in vivo behavior of the model complex [M(APPA)(CO)3] (appa = [(5-amino-pentyl)-pyridin-2-yl-methyl-amino]-acetic acid)

Autor: Albert Stichelberger, Roger Schibli, P.A Schubiger, Robert Waibel, Cécile Dumas

Publikováno v: Nuclear Medicine and Biology. 30:465-470

A general synthetic approach for potent tridentate, bifunctional chelating agent (BFCA) for the [M(CO)(3)](+) fragment (M = (99g)Tc, (99m)Tc, and Re) has been elaborated. The strategy allows the facile preparation of BFCA with a pendent amino or carb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2a54837a3d7be2561437a8218146c22
https://doi.org/10.1016/s0969-8051(03)00032-5

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Biokinetics of a F(ab′)3Iodine-131 Labeled Antigen Binding Construct (MAb 35) Directed Against CEA in Patients with Colorectal Carcinoma

Autor: A. Bischof Delaloye, G. Kuenzi, R.E. Offord, R. Waibel, M. Gillet, Franz Buchegger, G. Storto, P.A. Schubiger

Publikováno v: Cancer Biotherapy and Radiopharmaceuticals. 16:371-379

An 131I labeled trivalent antigen binding construct, formed from 3 Fab' fragments of murine anti-CEA monoclonal antibody (Mab) 35, has shown favorable biokinetics in animal studies.The aim of this study was to evaluate biodistribution and tumor uptak

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::922007120ee9b79deb65a7a4d5b2b966
https://doi.org/10.1089/108497801753354276

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Renal Pathology After Arterial Yttrium-90 Microsphere Administration in Pigs A Model for Superselective Radioembolization Therapy

Autor: L. Geiger, Jürgen Triller, P.A. Schubiger, Daniel Mettler, Arthur Zimmermann, H. Rösler

Publikováno v: Investigative Radiology. 30:716-723

RATIONALE AND OBJECTIVES To test the selectivity of tissue damage in radioembolization, the authors performed an experimental study using superselective administration of yttrium-90 particles to deliver up to 100 Gy to the porcine kidney. Patterns an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce52c34847345f092d5ca218c8abec43
https://doi.org/10.1097/00004424-199512000-00005

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A lipophilic complex with incorporated in liposomes suitable for radiotherapy

Autor: P.A. Schubiger, Urs O. Häfeli, H. G. Weder, L.X. Tiefenauer

Publikováno v: International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology. 18:449-454

Liposomes with a 70 nm diameter were made by the detergent removal technique on a gel filtration column. The complex oxodichloroethoxy- bis -(triphenylphosphine)rhenium(V) = (Rephos) was irradiated by neutrons in the reactor at PSI. 45 ± 5% of the r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e5d1e16763023ac7605536e5ae88cf0
https://doi.org/10.1016/0883-2897(91)90104-s

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90Y-resin particles—Animal experiments on pigs with regard to the introduction of superselective embolization therapy

Autor: Jürgen Triller, P.A. Schubiger, H.-F. Beer, L. Geiger, Daniel Mettler, H. Rösler, W Schilt, Arthur Zimmermann

Publikováno v: International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology. 18:305-311

Resin particles (diameter 45-75 microns) were labelled with 90Y, suspended in a glucose/dextran solution and infused into the kidneys of 3-month-old pigs (tumour model). Both kidneys of each animal were embolized with particles, but only one with act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::094201787a277d02051c0987179b4869
https://doi.org/10.1016/0883-2897(91)90126-6

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Catalytic enantioselective synthesis of 18F-fluorinated alpha-amino acids under phase-transfer conditions using (S)-NOBIN

Autor: I. K. Mosevich, Michael A. Nader, Simon M. Ametamey, Raisa Krasikova, O. F. Kuznetsova, Olga S. Fedorova, V. V. Zaitsev, S. V. Shatik, P.A Schubiger, Yu. N. Belokon, Š Vyskočil

Publikováno v: Nuclear medicine and biology. 31(5)

We describe a new method for the asymmetric synthesis of [(18)F]fluorinated aromatic alpha-amino acids (FAA) under phase transfer conditions using achiral glycine derivative NiPBPGly and (S)-NOBIN as a novel substrate/catalyst pair. The key alkylatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edecde7e7d47b63d855204e820e054b1
https://pubmed.ncbi.nlm.nih.gov/15219278

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Elektronická kniha

PET Chemistry : The Driving Force in Molecular Imaging

Autor: P.A. Schubiger, L. Lehmann, M. Friebe

Personalized medicine employing patient-based tailor-made therapeutic drugs is taking over treatment paradigms in a variety of?elds in oncology and the central nervous system. The success of such therapies is mainly dependent on ef?cacious therapeuti

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PET Chemistry: The Driving Force in Molecular Imaging

Autor: Matthias Friebe, David J. Yang, P.A. Schubiger, Lutz Lehmann

Publikováno v: Journal of Nuclear Medicine. 48:1750-1750

PET Chemistry: The Driving Force in Molecular Imaging describes the development of radiochemicals as concepts move from bench work to clinical products. Molecular targets have been applied as tools for personalized medicine in the areas of disease im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd8287a632f004862c39854d5b80db3d
https://doi.org/10.2967/jnumed.107.043810

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Akademický článek

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