Zobrazeno 1 - 10
of 107
pro vyhledávání: '"P.A. Lefevre"'
Publikováno v:
Regulatory Toxicology and Pharmacology. 34:287-291
The presence of structurally diverse chemicals as contaminants in the environment has led to concerns regarding their possible endocrine disturbing effects. Recently, some ultraviolet absorbing components of sunscreen preparations have given positive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70ba20095f82a6c8e4b20f4fb3b1acec
https://doi.org/10.1006/rtph.2001.1511
https://doi.org/10.1006/rtph.2001.1511
Autor:
J. Ashby, P.A. Lefevre
Publikováno v:
Regulatory Toxicology and Pharmacology. 31:92-105
A review of the many test protocols employed for the Hershberger castrated male rat assay is presented. The critical protocol variables thereby defined have been evaluated experimentally. Strong antiandrogens inhibit the regrowth of sex accessory tis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bfeeea6524d9397031b4fcaf2c835ef
https://doi.org/10.1006/rtph.1999.1372
https://doi.org/10.1006/rtph.1999.1372
Publikováno v:
Environmental and Molecular Mutagenesis. 34:148-153
The potent rat liver carcinogen 6-p-dimethylaminophenylazobenzthiazole (6BT) and its reported noncarcinogenic analogue 5-p-dimethylaminophenylazobenzthiazole (5BT; evaluated for carcinogenicity under the similar limited bioassay conditions used for 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9253e73e27c9661cbb42dc220ad76292
https://doi.org/10.1002/(sici)1098-2280(1999)34:2/3<148::aid-em14>3.0.co
https://doi.org/10.1002/(sici)1098-2280(1999)34:2/3<148::aid-em14>3.0.co
Publikováno v:
Environmental and Molecular Mutagenesis. 32:163-172
The mutagenicity of the rodent carcinogen methyl methanesulphonate (MMS) to the liver and bone marrow of MutaMouse lacZ- transgenic mice was evaluated. A single intraperitoneal (i.p.) dose of 100 mg/kg MMS gave a strong positive response in the liver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b59bc198c0021c154fa09a8f9cf70817
https://doi.org/10.1002/(sici)1098-2280(1998)32:2<163::aid-em12>3.0.co
https://doi.org/10.1002/(sici)1098-2280(1998)32:2<163::aid-em12>3.0.co
Autor:
P.A. Lefevre, J. Ashby
Publikováno v:
Regulatory Toxicology and Pharmacology. 26:330-337
Kelce and Wilson (J. Mol. Med. 75, 198-207, 1997) have suggested that dosing chemicals to newly weaned male rats for 1 month may yield a useful assay for antiandrogens. This suggestion was supported by reference to unpublished data on the antiandroge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5422f4cafc3ed20d5c15f5ee180f2263
https://doi.org/10.1006/rtph.1997.1177
https://doi.org/10.1006/rtph.1997.1177
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 393:263-281
Male rat dominant lethal (DL) assays conducted on the herbicide acetochlor are described. Single dose studies conducted at the maximum tolerated dose (MTD, ≤1000 mg/kg) produced no effects on any of the DL assay parameters at any of the ten weekly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b0b88715e0cd4b9e8182def7c9498fb
https://doi.org/10.1016/s1383-5718(97)00111-3
https://doi.org/10.1016/s1383-5718(97)00111-3
Autor:
Helen Tinwell, John Ashby, Trevor Green, L. Kier, WF Heydens, Age Wilson, G.A. Willis, P.A. Lefevre, Mjl Clapp
Publikováno v:
Human & Experimental Toxicology. 15:702-735
Comprehensive toxicological studies of the herbicide acetochlor are presented and discussed. Although it gave a negative profile of responses in the many toxicity tests conducted there were some findings that prompted further investigation. First, al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84c27d1b4bbb9a1d9f9303c946636f17
https://doi.org/10.1177/096032719601500902
https://doi.org/10.1177/096032719601500902
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 307:501-508
Young adult (approximately 8 w) and old (approximately 72 w) lac I transgenic mice have been exposed to a single oral dose of dimethyl nitrosamine (NDMA). 2.5 h later unscheduled DNA synthesis was observed in the liver of the young animals (19.5 NG;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adba5204ec0e76267c6ec9069fe3c57a
https://doi.org/10.1016/0027-5107(94)90261-5
https://doi.org/10.1016/0027-5107(94)90261-5
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 307:169-173
The lacZ MutaTMmouse transgenic mutation assay was recently adapted into a selective assay based on use of E. coli galE − bacteria and phenyl galactoside (p-gal). A preliminary assessment of this selective assay was undertaken using a single oral d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e933708fe3204ba16f5076ef8a081967
https://doi.org/10.1016/0027-5107(94)90289-5
https://doi.org/10.1016/0027-5107(94)90289-5
The non-genotoxicity to rodents of the potent rodent bladder carcinogens o-anisidine and p-cresidine
Autor:
D. Gulati, Gunnar Brunborg, R. Shanu-Wilson, Jørn A. Holme, B. Pool-Zobel, J.P. Wojciechowski, Peter Schmezer, Helen Tinwell, E.J. Søderlund, P.A. Lefevre, John Ashby
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 250:115-133
The two potent rodent bladder carcinogens o -anisidine and p -cresidine, and the structurally related non-carcinogen 2,4-dimethoxyaniline, have been extensively evaluated for genotoxicity to rodents and found to be inactive. Most data were generated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df48a0832407aaebb307be13c5e3e888
https://doi.org/10.1016/0027-5107(91)90168-n
https://doi.org/10.1016/0027-5107(91)90168-n