Výsledky vyhledávání - "P.A. Ferchmin"

Memantine has a nicotinic neuroprotective pathway in acute hippocampal slices after an NMDA insult

Autor: Yancy Ferrer-Acosta, Sergio Rodriguez-Massó, Dinely Pérez, Vesna A. Eterovic, P.A. Ferchmin, Antonio Henrique Martins

Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA. 84

Memantine is a non-competitive antagonist with a moderate affinity to the N-methyl-d-Aspartate (NMDA) receptor. The present study assessed memantine's neuroprotective activity using electrophysiology of ex-vivo hippocampal slices. Interestingly, a ni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc4960e0050489051ae7d47b430ec079
https://pubmed.ncbi.nlm.nih.gov/35944748

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Neuroprotective activity of (1S,2E,4R,6R,-7E,11E)-2,7,11-cembratriene-4,6-diol (4R) in vitro and in vivo in rodent models of brain ischemia

Autor: Zhenfeng Xu, K.A. El Sayed, P. Alvarez, Antonio H. Martins, Jiukuan Hao, Byron D. Ford, Vesna A. Eterovic, C. Mu, P.A. Ferchmin, Jing Hu

Publikováno v: Neuroscience. 291:250-259

(1S,2E,4R,6R,-7E,11E)-2,7,11-cembratriene-4,6-diol (4R) is a precursor to key flavor ingredients in leaves of Nicotiana species. The present study shows 4R decreased brain damage in rodent ischemic stroke models. The 4R-pretreated mice had lower infa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::409ef98ddbe30da1285f5fd299b662c2
https://doi.org/10.1016/j.neuroscience.2015.02.001

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Paraoxon and Pyridostigmine Interfere with Neural Stem Cell Differentiation

Autor: Sophia La Banca de Oliveira, José W. Rodríguez, Vesna A. Eterovic, Cleber A. Trujillo, P.A. Ferchmin, Priscilla D. Negraes, Nawal M. Boukli, Luis A. Cubano, Verónica O Berríos, Telma T. Schwindt, Henning Ulrich, Antonio H. Martins

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Acetylcholinesterase (AChE) inhibition has been described as the main mechanism of organophosphate (OP)-evoked toxicity. OPs represent a human health threat, because chronic exposure to low doses can damage the developing brain, and acute exposure ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e442c1acbc0b8d9989547f7ca2c3410
https://doi.org/10.1007/s11064-015-1548-7

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4R-Cembranoid Improves Outcomes after 6-Hydroxydopamine Challenge in Both In vitro and In vivo Models of Parkinson's Disease

Autor: Jiukuan Hao, Kim B. Seroogy, P.A. Ferchmin, Ann M. Hemmerle, Jing Hu, Vesna A. Eterovic

Publikováno v: Frontiers in Neuroscience
Frontiers in Neuroscience, Vol 11 (2017)

(1S, 2E, 4R, 6R,-7E, 11E)-2, 7, 11-cembratriene-4, 6-diol (4R) is one of the cembranoids found in tobacco leaves. Previous studies have found that 4R protected acute rat hippocampal slices against neurotoxicity induced by N-methyl-D-aspartate (NMDA)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9462ddd0c0d2e4fbba8f757bdc03ecaf
http://europepmc.org/articles/PMC5447022

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γ-Aminobutyric acid type a receptor inhibition triggers a nicotinic neuroprotective mechanism

Autor: Vesna A. Eterovic, William Castro Alvarez, P.A. Ferchmin, Mario A. Penzo, Dinely Pérez, Héctor M. Maldonado

Publikováno v: Journal of Neuroscience Research. 91:416-425

Nicotinic acetylcholine receptor (nAChR)-mediated neuroprotection has been implicated in the treatment of neurodegenerative disorders such as Alzheimer's and Parkinson's diseases and hypoxic ischemic events as well as other diseases hallmarked by exc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f55dea661fec3aa9bba3856f0fa1c5f
https://doi.org/10.1002/jnr.23155

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Neuroprotection Against Diisopropylfluorophosphate in Acute Hippocampal Slices

Autor: Dinely Pérez, Brenda L. Cuadrado, Antonio H. Martins, Vesna A. Eterovic, P.A. Ferchmin, Marimée Carrasco

Publikováno v: Neurochemical research. 40(10)

Diisopropylfluorophosphate (DFP) is an irreversible inhibitor of acetylcholine esterase (AChE) and a surrogate of the organophosphorus (OP) nerve agent sarin. The neurotoxicity of DFP was assessed as a reduction of population spike (PS) area elicited

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f5e3432f7050de84aa8e318d539c974
https://pubmed.ncbi.nlm.nih.gov/26438150

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