Zobrazeno 1 - 10
of 1 236
pro vyhledávání: '"P. van Eyk"'
Autor:
Dongping Du, Saurabh Bhardwaj, Yingzhou Lu, Yizhi Wang, Sarah J. Parker, Zhen Zhang, Jennifer E. Van Eyk, Guoqiang Yu, Robert Clarke, David M. Herrington, Yue Wang
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Bioinformatics software tools are essential to identify informative molecular features that define different phenotypic sample groups. Among the most fundamental and interrelated tasks are missing value imputation, signature gene detection,
Externí odkaz:
https://doaj.org/article/187793d404624b01ad59abda435ac11d
Autor:
Bart Van Puyvelde, Christie L. Hunter, Maxim Zhgamadze, Sudha Savant, Y. Oliver Wang, Esthelle Hoedt, Koen Raedschelders, Matt Pope, Carissa A. Huynh, V. Krishnan Ramanujan, Warren Tourtellotte, Morteza Razavi, N. Leigh Anderson, Geert Martens, Dieter Deforce, Qin Fu, Maarten Dhaenens, Jennifer E. Van Eyk
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract The global scientific response to COVID 19 highlighted the urgent need for increased throughput and capacity in bioanalytical laboratories, especially for the precise quantification of proteins that pertain to health and disease. Acoustic ej
Externí odkaz:
https://doaj.org/article/68382310f23344128261d2833db4b610
Autor:
Stanislav Tsitkov, Kelsey Valentine, Velina Kozareva, Aneesh Donde, Aaron Frank, Susan Lei, the Answer ALS Consortium, Jennifer E. Van Eyk, Steve Finkbeiner, Jeffrey D. Rothstein, Leslie M. Thompson, Dhruv Sareen, Clive N. Svendsen, Ernest Fraenkel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Amyotrophic Lateral Sclerosis (ALS), like many other neurodegenerative diseases, is highly heritable, but with only a small fraction of cases explained by monogenic disease alleles. To better understand sporadic ALS, we report epigenomic pro
Externí odkaz:
https://doaj.org/article/99c7b8055b0b402a8beedb66a340ca58
Autor:
Gatto, Laurent, Aebersold, Ruedi, Cox, Juergen, Demichev, Vadim, Derks, Jason, Emmott, Edward, Franks, Alexander M., Ivanov, Alexander R., Kelly, Ryan T., Khoury, Luke, Leduc, Andrew, MacCoss, Michael J., Nemes, Peter, Perlman, David H., Petelski, Aleksandra A., Rose, Christopher M., Schoof, Erwin M., Van Eyk, Jennifer, Vanderaa, Christophe, Yates III, John R., Slavov, Nikolai
Publikováno v:
Nature Methods, 20, 375--386 (2023)
Analyzing proteins from single cells by tandem mass spectrometry (MS) has become technically feasible. While such analysis has the potential to accurately quantify thousands of proteins across thousands of single cells, the accuracy and reproducibili
Externí odkaz:
http://arxiv.org/abs/2207.10815
Autor:
Scheuner, Joel, Eismann, Simon, Talluri, Sacheendra, van Eyk, Erwin, Abad, Cristina, Leitner, Philipp, Iosup, Alexandru
Making serverless computing widely applicable requires detailed performance understanding. Although contemporary benchmarking approaches exist, they report only coarse results, do not apply distributed tracing, do not consider asynchronous applicatio
Externí odkaz:
http://arxiv.org/abs/2205.07696
Autor:
Rudrarup Bhattacharjee, Lachlan A. Jolly, Mark A. Corbett, Ing Chee Wee, Sushma R. Rao, Alison E. Gardner, Tarin Ritchie, Eline J. H. van Hugte, Ummi Ciptasari, Sandra Piltz, Jacqueline E. Noll, Nazzmer Nazri, Clare L. van Eyk, Melissa White, Dani Fornarino, Cathryn Poulton, Gareth Baynam, Lyndsey E. Collins-Praino, Marten F. Snel, Nael Nadif Kasri, Kim M. Hemsley, Paul Q. Thomas, Raman Kumar, Jozef Gecz
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-25 (2024)
Abstract We implicated the X-chromosome THOC2 gene, which encodes the largest subunit of the highly-conserved TREX (Transcription-Export) complex, in a clinically complex neurodevelopmental disorder with intellectual disability as the core phenotype.
Externí odkaz:
https://doaj.org/article/f655e25df84a4da1addb5bf08b495565
Autor:
Rebekah de Nys, Clare L. van Eyk, Tarin Ritchie, Rikke S. Møller, Ingrid E. Scheffer, Carla Marini, Rudrarup Bhattacharjee, Raman Kumar, Jozef Gecz
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Clustering Epilepsy (CE) is an epileptic disorder with neurological comorbidities caused by heterozygous variants of the X chromosome gene Protocadherin 19 (PCDH19). Recent studies have implicated dysregulation of the Nuclear Hormone Recepto
Externí odkaz:
https://doaj.org/article/49c5d18714fc434c9a7aaf572909f7c5
Autor:
Functional, Participants in a NIH Workshop on, Proteomics, Integrative, Johnson, Kristin E. Burnum, Conrads, Thomas P., Drake, Richard R., Herr, Amy E., Iyengar, Ravi, Kelly, Ryan T., Lundberg, Emma, MacCoss, Michael J., Naba, Alexandra, Nolan, Garry P., Pevzner, Pavel A., Rodland, Karin D., Sechi, Salvatore, Slavov, Nikolai, Spraggins, Jeffrey M., Van Eyk, Jennifer E., Vidal, Marc, Vogel, Christine, Walt, David R., Kelleher, Neil L.
All human diseases involve proteins, yet our current tools to characterize and quantify them are limited. To better elucidate proteins across space, time, and molecular composition, we provide provocative projections for technologies to meet the chal
Externí odkaz:
http://arxiv.org/abs/2108.07660
Publikováno v:
The Retail and Marketing Review, Vol 19, Iss 2, Pp 44-53 (2023)
This research aimed to examine the effect of gender and age on shopping mall customers’ perceived utilitarian and hedonic value. The quantitative study was followed, and data was collected through self-administered questionnaires. Only respondents
Externí odkaz:
https://doaj.org/article/3bf6ed637c014fa395a4f82f840f548e
Autor:
Joan M. Bathon, Michael Centola, Xiaoqian Liu, Zhicheng Jin, Weihua Ji, Nicholas S. Knowlton, Iván Ferraz-Amaro, Qin Fu, Jon T. Giles, Mary Chester Wasko, C. Michael Stein, Jennifer E. Van Eyk
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-12 (2023)
Abstract Background Cardiovascular (CV) risk estimation calculators for the general population underperform in patients with rheumatoid arthritis (RA). The purpose of this study was to identify relevant protein biomarkers that could be added to tradi
Externí odkaz:
https://doaj.org/article/f49305ff219a466d96de08cfc25c96e6