Zobrazeno 1 - 10
of 45
pro vyhledávání: '"P. van 't Slot"'
Autor:
N. Dirkx, Wout J. Weuring, E. De Vriendt, N. Smal, J. van de Vondervoort, Ruben van ’t Slot, M. Koetsier, N. Zonnekein, Tim De Pooter, S. Weckhuysen, B. P. C. Koeleman
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Background Prime editing (PE) is the most recent gene editing technology able to introduce targeted alterations to the genome, including single base pair changes, small insertions, and deletions. Several improvements to the PE machinery have
Externí odkaz:
https://doaj.org/article/1f458b182d604f85b62a269b125c9ff9
Publikováno v:
Handelingen, Vol 49, Iss 3 (2022)
Al sinds jaar en dag maakt opleidingssupervisie deel uit van de driejarige masteropleidingen van de Protestantse Theologische Universiteit in Amsterdam en Groningen. Sinds de laatste onderwijsherziening heet deze opleiding Master Theologie, een oplei
Externí odkaz:
https://doaj.org/article/0c00139b0f6147809ce6fcf6b054a15e
Autor:
Wout J Weuring, Sakshi Singh, Linda Volkers, Martin B Rook, Ruben H van 't Slot, Marjolein Bosma, Marco Inserra, Irina Vetter, Nanda M Verhoeven-Duif, Kees P J Braun, Mirko Rivara, Bobby P C Koeleman
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0219106 (2020)
Dravet syndrome is caused by dominant loss-of-function mutations in SCN1A which cause reduced activity of Nav1.1 leading to lack of neuronal inhibition. On the other hand, gain-of-function mutations in SCN8A can lead to a severe epileptic encephalopa
Externí odkaz:
https://doaj.org/article/6bee8c3f2c6649e9a69da93d49666e56
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Carolien G de Kovel, Flip Mulder, Jessica van Setten, Ruben van 't Slot, Abdullah Al-Rubaish, Abdullah M Alshehri, Khalid Al Faraidy, Abdullah Al-Ali, Mohammed Al-Madan, Issa Al Aqaili, Emmanuel Larbi, Rudaynah Al-Ali, Alhusain Alzahrani, Folkert W Asselbergs, Bobby P C Koeleman, Amein Al-Ali
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0146502 (2016)
Coronary Artery Disease (CAD) remains the leading cause of mortality worldwide. Mortality rates associated with CAD have shown an exceptional increase particularly in fast developing economies like the Kingdom of Saudi Arabia (KSA). Over the past twe
Externí odkaz:
https://doaj.org/article/f122dbf0511048a8b0ab407fdb727226
Autor:
Yingchang Lu, Martijn E.T. Dollé, Sandra Imholz, Ruben van 't Slot, W.M.Monique Verschuren, Cisca Wijmenga, Edith J.M. Feskens, Jolanda M.A. Boer
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 12, Pp 2582-2589 (2008)
The known genetic variants determining plasma HDL cholesterol (HDL-C) levels explain only part of its variation. Three hundred eighty-four single nucleotide polymorphisms (SNPs) across 251 genes based on pathways potentially relevant to HDL-C metabol
Externí odkaz:
https://doaj.org/article/39a782b0985047ccb6cee573c292c5a6
Autor:
Olga Gorlova, Jose-Ezequiel Martin, Blanca Rueda, Bobby P. C. Koeleman, Jun Ying, Maria Teruel, Lina-Marcela Diaz-Gallo, Jasper C. Broen, Madelon C. Vonk, Carmen P. Simeon, Behrooz Z. Alizadeh, Marieke J. H. Coenen, Alexandre E. Voskuyl, Annemie J. Schuerwegh, Piet L. C. M. van Riel, Marie Vanthuyne, Ruben van 't Slot, Annet Italiaander, Roel A. Ophoff, Nicolas Hunzelmann, Vicente Fonollosa, Norberto Ortego-Centeno, Miguel A. González-Gay, Francisco J. García-Hernández, María F. González-Escribano, Paolo Airo, Jacob van Laar, Jane Worthington, Roger Hesselstrand, Vanessa Smith, Filip de Keyser, Fredric Houssiau, Meng May Chee, Rajan Madhok, Paul G. Shiels, Rene Westhovens, Alexander Kreuter, Elfride de Baere, Torsten Witte, Leonid Padyukov, Annika Nordin, Raffaella Scorza, Claudio Lunardi, Benedicte A. Lie, Anna-Maria Hoffmann-Vold, Øyvind Palm, Paloma García de la Peña, Patricia Carreira, John Varga, Monique Hinchcliff, Annette T. Lee, Pravitt Gourh, Christopher I. Amos, Frederick M. Wigley, Laura K. Hummers, J. Lee Nelson, Gabriella Riemekasten, Ariane Herrick, Lorenzo Beretta, Carmen Fonseca, Christopher P. Denton, Peter K. Gregersen, Sandeep Agarwal, Shervin Assassi, Filemon K. Tan, Frank C. Arnett, Timothy R. D. J. Radstake, Maureen D. Mayes, Javier Martin
Publikováno v:
PLoS Genetics, Vol 7, Iss 8 (2011)
Externí odkaz:
https://doaj.org/article/4d5606e9cb53448b8c0723d7f6339f4c
Autor:
Olga Gorlova, Jose-Ezequiel Martin, Blanca Rueda, Bobby P C Koeleman, Jun Ying, Maria Teruel, Lina-Marcela Diaz-Gallo, Jasper C Broen, Madelon C Vonk, Carmen P Simeon, Behrooz Z Alizadeh, Marieke J H Coenen, Alexandre E Voskuyl, Annemie J Schuerwegh, Piet L C M van Riel, Marie Vanthuyne, Ruben van 't Slot, Annet Italiaander, Roel A Ophoff, Nicolas Hunzelmann, Vicente Fonollosa, Norberto Ortego-Centeno, Miguel A González-Gay, Francisco J García-Hernández, María F González-Escribano, Paolo Airo, Jacob van Laar, Jane Worthington, Roger Hesselstrand, Vanessa Smith, Filip de Keyser, Fredric Houssiau, Meng May Chee, Rajan Madhok, Paul G Shiels, Rene Westhovens, Alexander Kreuter, Elfride de Baere, Torsten Witte, Leonid Padyukov, Annika Nordin, Raffaella Scorza, Claudio Lunardi, Benedicte A Lie, Anna-Maria Hoffmann-Vold, Oyvind Palm, Paloma García de la Peña, Patricia Carreira, Spanish Scleroderma Group, John Varga, Monique Hinchcliff, Annette T Lee, Pravitt Gourh, Christopher I Amos, Frederick M Wigley, Laura K Hummers, J Lee Nelson, Gabriella Riemekasten, Ariane Herrick, Lorenzo Beretta, Carmen Fonseca, Christopher P Denton, Peter K Gregersen, Sandeep Agarwal, Shervin Assassi, Filemon K Tan, Frank C Arnett, Timothy R D J Radstake, Maureen D Mayes, Javier Martin
Publikováno v:
PLoS Genetics, Vol 7, Iss 7, p e1002178 (2011)
The aim of this study was to determine, through a genome-wide association study (GWAS), the genetic components contributing to different clinical sub-phenotypes of systemic sclerosis (SSc). We considered limited (lcSSc) and diffuse (dcSSc) cutaneous
Externí odkaz:
https://doaj.org/article/a5f42acd89a14eab989b4aae529eeb02
Autor:
Sebastiaan M Bol, Perry D Moerland, Sophie Limou, Yvonne van Remmerden, Cédric Coulonges, Daniëlle van Manen, Joshua T Herbeck, Jacques Fellay, Margit Sieberer, Jantine G Sietzema, Ruben van 't Slot, Jeremy Martinson, Jean-François Zagury, Hanneke Schuitemaker, Angélique B van 't Wout
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e17190 (2011)
HIV-1 infected macrophages play an important role in rendering resting T cells permissive for infection, in spreading HIV-1 to T cells, and in the pathogenesis of AIDS dementia. During highly active anti-retroviral treatment (HAART), macrophages keep
Externí odkaz:
https://doaj.org/article/ec933f9d95a943fd86decd23dded18ac
Autor:
Daniëlle van Manen, Olivier Delaneau, Neeltje A Kootstra, Brigitte D Boeser-Nunnink, Sophie Limou, Sebastiaan M Bol, Judith A Burger, Aeilko H Zwinderman, Perry D Moerland, Ruben van 't Slot, Jean-François Zagury, Angélique B van 't Wout, Hanneke Schuitemaker
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22208 (2011)
BACKGROUND: AIDS develops typically after 7-11 years of untreated HIV-1 infection, with extremes of very rapid disease progression (15 years). To reveal additional host genetic factors that may impact on the clinical course of HIV-1 infection, we des
Externí odkaz:
https://doaj.org/article/9eb3b24a55104c6095df7a7a21e54918