Zobrazeno 1 - 10
of 160
pro vyhledávání: '"P. de Vlaming"'
Autor:
de Vlaming, Ronald, Slob, Eric A. W.
Joint diagonalization of a set of positive (semi)-definite matrices has a wide range of analytical applications, such as estimation of common principal components, estimation of multiple variance components, and blind signal separation. However, when
Externí odkaz:
http://arxiv.org/abs/2110.03235
Autor:
Hans van Kippersluis, Pietro Biroli, Rita Dias Pereira, Titus J. Galama, Stephanie von Hinke, S. Fleur W. Meddens, Dilnoza Muslimova, Eric A. W. Slob, Ronald de Vlaming, Cornelius A. Rietveld
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Measurement error in polygenic indices (PGIs) attenuates the estimation of their effects in regression models. We analyze and compare two approaches addressing this attenuation bias: Obviously Related Instrumental Variables (ORIV) and the PG
Externí odkaz:
https://doaj.org/article/9b2301c9e74b47289315b4c95041393b
Akademický článek
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Multivariate estimation of factor structures of complex traits using SNP-based genomic relationships
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-11 (2022)
Abstract Background Heritability and genetic correlation can be estimated from genome-wide single-nucleotide polymorphism (SNP) data using various methods. We recently developed multivariate genomic-relatedness-based restricted maximum likelihood (MG
Externí odkaz:
https://doaj.org/article/4fc565e0deb04703976500ec4dd8d233
Autor:
Annemarieke de Vlaming, Kyle G. Mathews, Jonathan A. Hash, Erin K. Keenihan, Samantha Sommer, Luke Borst, Shelly L. Vaden
Publikováno v:
Journal of Investigative Surgery, Vol 35, Iss 3, Pp 481-495 (2022)
Surgical procedures that maintain continence with minimal complication following resection of trigono-urethral urothelial carcinoma (UC) are limited in canines; therefore, palliative options are often pursued. A feasible tumor resection option may im
Externí odkaz:
https://doaj.org/article/828371cb9c884e8c830dc882976ebc4b
The identification of mediating effects using genome-based restricted maximum likelihood estimation.
Publikováno v:
PLoS Genetics, Vol 19, Iss 2, p e1010638 (2023)
Mediation analysis is commonly used to identify mechanisms and intermediate factors between causes and outcomes. Studies drawing on polygenic scores (PGSs) can readily employ traditional regression-based procedures to assess whether trait M mediates
Externí odkaz:
https://doaj.org/article/7f914e77cff64f77854d736e19623472
Autor:
Ronald de Vlaming, Eric A. W. Slob, Philip R. Jansen, Alain Dagher, Philipp D. Koellinger, Patrick J. F. Groenen, Cornelius A. Rietveld
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-9 (2021)
Ronald de Vlaming and Eric Slob et al. present MGREML, a multivariate tool to estimate pairwise genetic correlations between multiple traits. They apply MGREML to UK Biobank data for 74 brain imaging phenotypes and 8 behavioral traits, demonstrating
Externí odkaz:
https://doaj.org/article/61965f8c3cfa45558858895d9c0d260e
Autor:
Travis T. Mallard, Richard Karlsson Linnér, Andrew D. Grotzinger, Sandra Sanchez-Roige, Jakob Seidlitz, Aysu Okbay, Ronald de Vlaming, S. Fleur W. Meddens, Abraham A. Palmer, Lea K. Davis, Elliot M. Tucker-Drob, Kenneth S. Kendler, Matthew C. Keller, Philipp D. Koellinger, K. Paige Harden
Publikováno v:
Cell Genomics, Vol 2, Iss 6, Pp 100140- (2022)
Summary: Understanding which biological pathways are specific versus general across diagnostic categories and levels of symptom severity is critical to improving nosology and treatment of psychopathology. Here, we combine transdiagnostic and dimensio
Externí odkaz:
https://doaj.org/article/e46aa5b1293c4d778b4c92cbacfead66
Autor:
V. Bansal, M. Mitjans, C. A. P. Burik, R. K. Linnér, A. Okbay, C. A. Rietveld, M. Begemann, S. Bonn, S. Ripke, R. de Vlaming, M. G. Nivard, H. Ehrenreich, P. D. Koellinger
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Educational attainment and schizophrenia have a negative phenotypic relationship but show positive genetic correlation. Here, the authors study genetic dependence between the two traits and find that multiple genes have pleiotropic effects on both wi
Externí odkaz:
https://doaj.org/article/55c327660abc4980b3af8b9db2eaa44a
Akademický článek
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