Zobrazeno 1 - 2
of 2
pro vyhledávání: '"P. Y. Hor"'
Autor:
R. Kumar, L. Coronel, B. Somalanka, A. Raju, O. A. Aning, O. An, Y. S. Ho, S. Chen, S. Y. Mak, P. Y. Hor, H. Yang, M. Lakshmanan, H. Itoh, S. Y. Tan, Y. K. Lim, A. P. C. Wong, S. H. Chew, T. H. Huynh, B. C. Goh, C. Y. Lim, V. Tergaonkar, C. F. Cheok
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Several challenges are involved in direct targeting of mutant p53, while targeting altered fitness of cells with loss of wild type p53 is an alternative approach. Here they identify niclosamide to be selectively toxic to p53 deficient cells through a
Externí odkaz:
https://doaj.org/article/37b449460c1b4f2d9a57f838a3deed30
Autor:
C. Y. Lim, T. H. Huynh, Omer An, Y. K. Lim, P. Y. Hor, Anandhkumar Raju, Boon Cher Goh, Soo Yong Tan, Obed Akwasi Aning, Vinay Tergaonkar, Hui Ying Yang, Meiyappan Lakshmanan, Ying Swan Ho, Soo Hong Chew, Ramesh Kumar, Shuai Chen, Chit Fang Cheok, S. Y. Mak, L. Coronel, A. P. C. Wong, B. Somalanka, Hideki Itoh
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
There are considerable challenges in directly targeting the mutant p53 protein, given the large heterogeneity of p53 mutations in the clinic. An alternative approach is to exploit the altered fitness of cells imposed by loss-of-wild-type p53. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64f268ca4f77aff1f4e10afcfd10eaa7
http://europepmc.org/articles/PMC6158291
http://europepmc.org/articles/PMC6158291