Zobrazeno 1 - 10
of 966
pro vyhledávání: '"P. Wason"'
Autor:
Cherlin, Svetlana, Wason, James M S
In several clinical areas, traditional clinical trials often use a responder outcome, a composite endpoint that involves dichotomising a continuous measure. An augmented binary method that improves power whilst retaining the original responder endpoi
Externí odkaz:
http://arxiv.org/abs/2408.08636
Autor:
He, Honglu, Lu, Chen-lung, Ren, Jinhan, Dhar, Joni, Saunders, Glenn, Wason, John, Samuel, Johnson, Julius, Agung, Wen, John T.
Wire Arc Additive Manufacturing (WAAM) is a metal 3D printing technology that deposits molten metal wire on a substrate to form desired geometries. Articulated robot arms are commonly used in WAAM to produce complex geometric shapes. However, they mo
Externí odkaz:
http://arxiv.org/abs/2408.04677
Autor:
He, Honglu, Lu, Chen-lung, Saunders, Glenn, Yang, Pinghai, Schoonover, Jeffrey, Ajdelsztajn, Leo, Wason, John, Paternain, Santiago, Julius, Agung, Wen, John T.
Industrial robotic applications such as spraying, welding, and additive manufacturing frequently require fast, accurate, and uniform motion along a 3D spatial curve. To increase process throughput, some manufacturers propose a dual-robot setup to ove
Externí odkaz:
http://arxiv.org/abs/2404.06687
Under a generalised estimating equation analysis approach, approximate design theory is used to determine Bayesian D-optimal designs. For two examples, considering simple exchangeable and exponential decay correlation structures, we compare the effic
Externí odkaz:
http://arxiv.org/abs/2402.09938
Randomized controlled clinical trials provide the gold standard for evidence generation in relation to the efficacy of a new treatment in medical research. Relevant information from previous studies may be desirable to incorporate in the design and a
Externí odkaz:
http://arxiv.org/abs/2401.10592
Adaptive designs(AD) are a broad class of trial designs that allow preplanned modifications based on patient data providing improved efficiency and flexibility. However, a delay in observing the primary outcome variable can harm this added efficiency
Externí odkaz:
http://arxiv.org/abs/2306.04430
Autor:
Cherlin, Svetlana, Bigirumurame, Theophile, Grayling, Michael J, Nsengimana, Jérémie, Ouma, Luke, Santaolalla, Aida, Wan, Fang, Williamson, S Faye, Wason, James M S
Introduction: Even in effectively conducted randomised trials, the probability of a successful study remains relatively low. With recent advances in the next-generation sequencing technologies, there is a rapidly growing number of high-dimensional da
Externí odkaz:
http://arxiv.org/abs/2305.10174
Modern data analysis frequently involves large-scale hypothesis testing, which naturally gives rise to the problem of maintaining control of a suitable type I error rate, such as the false discovery rate (FDR). In many biomedical and technological ap
Externí odkaz:
http://arxiv.org/abs/2208.11418
Autor:
Michael Cole, James Wason, Jenn Walker, Naomi McGregor, Rebecca H Maier, Simon H Pearce, Penny Bradley, Faye Wolstenhulme, Irena Bibby, Lydia Grixti
Publikováno v:
BMJ Open, Vol 14, Iss 6 (2024)
Introduction Severe Graves’ disease is a life-changing condition with poor outcomes from currently available treatments. It is caused by directly pathogenic thyroid-stimulating hormone receptor-stimulating antibodies (TRAb), which are secreted from
Externí odkaz:
https://doaj.org/article/f7324f0310e148c3acfe10c7bc2b9885
Autor:
Martin Carby, Jasvir Parmar, Andrew Bryant, Thomas Chadwick, Luke Vale, Catherine Exley, Andrew J Fisher, Helen Hancock, Richard Thompson, Joanne Lally, Andrew R Gennery, Michelle Bardgett, Siân Russell, Michael White, James MS Wason, Nicola Goudie, Anneka Kershaw, Julia Phillipson, Alex Bevin-Nicholls, Hesther Smith, Laura Frisby, Rebecca Errington, Karthik Santhanakrishnan
Publikováno v:
BMJ Open Respiratory Research, Vol 11, Iss 1 (2024)
Background Long-term survival after lung transplantation is limited compared with other organ transplants. The main cause is development of progressive immune-mediated damage to the lung allograft. This damage, which can develop via multiple immune p
Externí odkaz:
https://doaj.org/article/25ff32a40f734970b727cb09b3679576