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Inflammatory bowel disease is associated with increased mucosal levels of bactericidal/permeability-increasing protein

Autor: S. J. H. Van Deventer, G. N. J. Tytgat, D. O. Obradov, P. W. Trown, H. Monajemi, J. Meenan, S. A. Radema, R. Lamping

Publikováno v: Gastroenterology, 110(3), 733-739. W.B. Saunders Ltd

Clinical sepsis seldom accompanies inflammatory bowel disease. The aim of this study was to measure colonic mucosal levels of the neutrophil product bactericidal/permeability-increasing protein (BPI), which kills gram-negative bacteria in addition to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::279c0516475219bfb00250b5d0ea7d2f
https://pubmed.ncbi.nlm.nih.gov/8608882

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Binding Characteristics of the Antiendotoxin Antibody Xomen-E5 to Bacterial Whole-Cell Antigens

Autor: K. J. Gorelick, E. Lim, D. M. Fishwild, D. M. Wood, D. T. Reardan, K. D. Knebel, J. B. Parent, P. J. Conlon, P. W. Trown

Publikováno v: Host Defense Dysfunction in Trauma, Shock and Sepsis ISBN: 9783642774072

Sepsis is a common, life-threatening complication of infection with gram-negative bacteria. While the pathophysiology of gram-negative sepsis has not been fully elucidated, a significant portion of the clinical syndrome can probably be attributed to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f7e4a79125a68e7c3f0e0a675e63734e
https://doi.org/10.1007/978-3-642-77405-8_156

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Reactivity of monoclonal antibody E5 with endotoxin. II. Binding to short- and long-chain smooth lipopolysaccharides

Autor: J B, Parent, H, Gazzano-Santoro, D M, Wood, E, Lim, P T, Pruyne, P W, Trown, P J, Conlon

Publikováno v: Circulatory shock. 38(1)

The murine monoclonal IgM antibody E5 has been shown to significantly reduce the mortality and morbidity of patients with Gram-negative sepsis in a multicenter randomized placebo-controlled clinical trial. The in vitro binding characteristics of mono

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fa5e65a48aa749dc170d76a1cc19bc1f
https://pubmed.ncbi.nlm.nih.gov/1382882

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Reactivity of monoclonal antibody E5 with endotoxin. I. Binding to lipid A and rough lipopolysaccharides

Autor: D M, Wood, J B, Parent, H, Gazzano-Santoro, E, Lim, P T, Pruyne, J M, Watkins, E S, Spoor, D T, Reardan, P W, Trown, P J, Conlon

Publikováno v: Circulatory shock. 38(1)

The murine IgM monoclonal antibody (mAb) E5 was produced by a hybridoma derived from spleen cells of a mouse immunized with the J5 rough mutant of Escherichia coli O111:B4. In a multicenter randomized placebo-controlled clinical trial, E5 has been sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3230d2a66c40ef1eee252c7551afda37
https://pubmed.ncbi.nlm.nih.gov/1394865

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Improved pharmacokinetics and tumor localization of immunotoxins constructed with the Mr 30,000 form of ricin A chain

Autor: P W, Trown, D T, Reardan, S F, Carroll, J B, Stoudemire, R T, Kawahata

Publikováno v: Cancer research. 51(16)

The two naturally occurring forms of ricin A chain, Mr 33,000 and Mr 30,000 (RTA33 and RTA30) have been purified, and their chemical compositions, toxicities, and tissue distributions have been determined. As reported previously, the in vitro and in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1854e0c28a3fb20a40e2c773efdfc34c
https://pubmed.ncbi.nlm.nih.gov/1868442

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Fluorinated pyrimidine nucleosides. 3. Synthesis and antitumor activity of a series of 5'-deoxy-5-fluoropyrimidine nucleosides

Autor: M. J. Holman, M. J. Kramer, P. W. Trown, A. F. Cook

Publikováno v: Journal of Medicinal Chemistry. 22:1330-1335

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d884fe1f779980fcdf1f519c203f1282
https://doi.org/10.1021/jm00197a010

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Dihydroretinoic acids and their derivatives. Synthesis and biological activity

Autor: R. Hansen, W. Bollag, H. C. Cheung, M. Buck, B. A. Pawson, U. Ineichen, R. J. L. Han, H. Pleil, Rüegg R, P. W. Trown

Publikováno v: Journal of Medicinal Chemistry. 20:918-925

The syntheses of the ring and four side-chain dihydroretinoic acids and/or their esters, 3-7, are described. The syntheses of several other retinoids containing a substituted aromatic ring are also included. The biological activity of the compounds w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d13a2168d4d2c5e9bd4934580deddc1
https://doi.org/10.1021/jm00217a011

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