Zobrazeno 1 - 10
of 27
pro vyhledávání: '"P. W. Teague"'
Autor:
Patrick S. Tarpey, Sam Behjati, Matthew D. Young, Inigo Martincorena, Ludmil B. Alexandrov, Sarah J. Farndon, Charlotte Guzzo, Claire Hardy, Calli Latimer, Adam P. Butler, Jon W. Teague, Adam Shlien, P. Andrew Futreal, Sohrab Shah, Ali Bashashati, Farzad Jamshidi, Torsten O. Nielsen, David Huntsman, Daniel Baumhoer, Sebastian Brandner, Jay Wunder, Brendan Dickson, Patricia Cogswell, Josh Sommer, Joanna J. Phillips, M. Fernanda Amary, Roberto Tirabosco, Nischalan Pillay, Stephen Yip, Michael R. Stratton, Adrienne M. Flanagan, Peter J. Campbell
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-6 (2017)
Chordoma is a rare often incurable malignant bone tumour. Here, the authors investigate driver mutations of sporadic chordoma in 104 cases, revealing duplications in notochordal transcription factor brachyury (T), PI3K signalling mutations, and mutat
Externí odkaz:
https://doaj.org/article/208559b87d8a4491810952fc9347c3ba
Autor:
Sam Behjati, Patrick S. Tarpey, Kerstin Haase, Hongtao Ye, Matthew D. Young, Ludmil B. Alexandrov, Sarah J. Farndon, Grace Collord, David C. Wedge, Inigo Martincorena, Susanna L. Cooke, Helen Davies, William Mifsud, Mathias Lidgren, Sancha Martin, Calli Latimer, Mark Maddison, Adam P. Butler, Jon W. Teague, Nischalan Pillay, Adam Shlien, Ultan McDermott, P. Andrew Futreal, Daniel Baumhoer, Olga Zaikova, Bodil Bjerkehagen, Ola Myklebost, M. Fernanda Amary, Roberto Tirabosco, Peter Van Loo, Michael R. Stratton, Adrienne M. Flanagan, Peter J. Campbell
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
Osteosarcoma is a primary malignancy of bone that affects children and adults. Here, the authors sequence childhood and adult osteosarcomas, identifying mutations in insulin-like growth factor signalling genes and distinct genomic rearrangement profi
Externí odkaz:
https://doaj.org/article/4d580842711a47b9a0ba6bb379bd365f
Autor:
Sam Behjati, Gunes Gundem, David C. Wedge, Nicola D. Roberts, Patrick S. Tarpey, Susanna L. Cooke, Peter Van Loo, Ludmil B. Alexandrov, Manasa Ramakrishna, Helen Davies, Serena Nik-Zainal, Claire Hardy, Calli Latimer, Keiran M. Raine, Lucy Stebbings, Andy Menzies, David Jones, Rebecca Shepherd, Adam P. Butler, Jon W. Teague, Mette Jorgensen, Bhavisha Khatri, Nischalan Pillay, Adam Shlien, P. Andrew Futreal, Christophe Badie, ICGC Prostate Group, Ultan McDermott, G. Steven Bova, Andrea L. Richardson, Adrienne M. Flanagan, Michael R. Stratton, Peter J. Campbell
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Ionizing radiation may induce irreparable DNA damage leading to cancer. Here, the authors identify a specific signature of mutations arising in patients exposed to ionizing radiation and suggest that radiation-induced tumorigenesis is associated with
Externí odkaz:
https://doaj.org/article/6591661632a94c5d9e36a5a48f8dcf2c
Autor:
Young Seok Ju, Ludmil B Alexandrov, Moritz Gerstung, Inigo Martincorena, Serena Nik-Zainal, Manasa Ramakrishna, Helen R Davies, Elli Papaemmanuil, Gunes Gundem, Adam Shlien, Niccolo Bolli, Sam Behjati, Patrick S Tarpey, Jyoti Nangalia, Charles E Massie, Adam P Butler, Jon W Teague, George S Vassiliou, Anthony R Green, Ming-Qing Du, Ashwin Unnikrishnan, John E Pimanda, Bin Tean Teh, Nikhil Munshi, Mel Greaves, Paresh Vyas, Adel K El-Naggar, Tom Santarius, V Peter Collins, Richard Grundy, Jack A Taylor, D Neil Hayes, David Malkin, ICGC Breast Cancer Group, ICGC Chronic Myeloid Disorders Group, ICGC Prostate Cancer Group, Christopher S Foster, Anne Y Warren, Hayley C Whitaker, Daniel Brewer, Rosalind Eeles, Colin Cooper, David Neal, Tapio Visakorpi, William B Isaacs, G Steven Bova, Adrienne M Flanagan, P Andrew Futreal, Andy G Lynch, Patrick F Chinnery, Ultan McDermott, Michael R Stratton, Peter J Campbell
Publikováno v:
eLife, Vol 3 (2014)
Recent sequencing studies have extensively explored the somatic alterations present in the nuclear genomes of cancers. Although mitochondria control energy metabolism and apoptosis, the origins and impact of cancer-associated mutations in mtDNA are u
Externí odkaz:
https://doaj.org/article/a97bb2e0fa0f4eb19b17cd3f405b0385
Autor:
Igor Rudan, Harry Campbell, P. W. Teague, Ozren Polasek, Andrew D. Carothers, Alan F. Wright, Nicholas D. Hastie, Ivana Kolcic, James L. Weber, Caroline Hayward
Publikováno v:
Annals of Human Genetics. 70:666-676
We have used genealogies and genomic polymorphisms to estimate individual inbreeding coefficients (F) in 50 subjects with an expected range (based on recent genealogies) of F from 0.0 to 0.0625. The estimates were based on two approaches, using genot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85bd62119f670b64f62a6736e6aea78e
https://doi.org/10.1111/j.1469-1809.2006.00263.x
https://doi.org/10.1111/j.1469-1809.2006.00263.x
Autor:
P. W. Teague, Wendy A. Bickmore
Publikováno v:
Chromosome Research. 10:707-715
Translocations are the most frequent chromosome structural aberration in the human population, yet little is known about their aetiology. Here, factors that might influence the occurrence of constitutional translocations in the population are examine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c18aee286fbdfe298279a52567d4310
https://doi.org/10.1023/a:1021589031769
https://doi.org/10.1023/a:1021589031769
Autor:
Barrie Jay, Marcelle Jay, S. Bundey, P. W. Teague, M A Aldred, R M Redmond, Shomi S. Bhattacharya, A C Bird, Alan F. Wright
Publikováno v:
Journal of Medical Genetics. 31:848-852
Three families with retinitis pigmentosa (RP) are described in which the disorder shows apparent X linked inheritance but does not show linkage to the RP2 and RP3 regions of the short arm of the X chromosome. The families are also inconsistent with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bf052cc77dc29c94f4489e6a2d791e9
https://doi.org/10.1136/jmg.31.11.848
https://doi.org/10.1136/jmg.31.11.848
Autor:
M. L. Watson, R. de Mey, Andrew D. Carothers, P L Allan, S. E. Pound, A F Wright, P. W. Teague, A M Macnicol, P M Pignatelli
Publikováno v:
Human Genetics. 90:569-571
A genetic heterogeneity analysis of 35 kindreds with adult-onset polycystic kidney disease (ADPKD) was carried out using the D16S85, D16S84, D16S125 and D16S94 loci that are closely linked to the PKD1 locus on chromosome 16. The results show that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb3e3c550b2bb96cc520b25fddd1a51
https://doi.org/10.1007/bf00217461
https://doi.org/10.1007/bf00217461
Autor:
Anthony J. Pelosi, David J. Porteous, J. K. Millar, Colin A. Semple, Walter J. Muir, Douglas Blackwood, Rebecca S. Devon, V. Murray, Paul Burgess, P. W. Teague, Susan Anderson, Tiina Kipari
Publikováno v:
Psychiatric genetics. 11(2)
We have undertaken a search for polymorphic sequence variation within Disrupted in Schizophrenia I and Disrupted in Schizophrenia 2 (DISC1 and DISC2), which are both novel genes that span a translocation breakpoint strongly associated with schizophre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da65cfab8147ac27173bcd19bcfa5686
https://pubmed.ncbi.nlm.nih.gov/11525420
https://pubmed.ncbi.nlm.nih.gov/11525420
Autor:
David J. Porteous, Susan Anderson, Walter J. Muir, Douglas Blackwood, V. Murray, Anthony J. Pelosi, P. W. Teague, Rebecca S. Devon
Publikováno v:
Molecular psychiatry. 6(3)
The G-protein coupled metabotropic glutamate receptors (GRMs/mGluRs) have been implicated in the aetiology of schizophrenia as they modulate the NMDA response and that of other neurotransmitters including dopamine and GABA.(1-3) Electrophysiological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95bf9ed4b8c551c5bc8bea6449eca816
https://pubmed.ncbi.nlm.nih.gov/11326300
https://pubmed.ncbi.nlm.nih.gov/11326300