Zobrazeno 1 - 10
of 87
pro vyhledávání: '"P. W. Snyder"'
Publikováno v:
Energy Strategy Reviews, Vol 56, Iss , Pp 101565- (2024)
The pressing global challenge of climate change necessitates a concerted effort to limit greenhouse gas emissions, particularly carbon dioxide. A critical pathway is to replace fossil fuel sources by electrification, including transportation. While e
Externí odkaz:
https://doaj.org/article/12f9c9b1734545a59e87a11ded121d1f
Autor:
Allison C. Sharrow, Emily Megill, Amanda J. Chen, Afifa Farooqi, Naveen Kumar Tangudu, Apoorva Uboveja, Stacy McGonigal, Nadine Hempel, Nathaniel W. Snyder, Ronald J. Buckanovich, Katherine M. Aird
Publikováno v:
Molecular Metabolism, Vol 89, Iss , Pp 102031- (2024)
Quiescence is a reversible cell cycle exit traditionally thought to be associated with a metabolically inactive state. Recent work in muscle cells indicates that metabolic reprogramming is associated with quiescence. Whether metabolic changes occur i
Externí odkaz:
https://doaj.org/article/fbeda01d725342f2a18d6f4dcb007d47
Autor:
Brian K Yorkgitis, Anne Fischer, Henry L Chang, Lindsey B Armstrong, Keith A Thatch, Donald A Plumley, Robin T Petroze, Shawn D Larson, John W Fitzwater, Oliver B Lao, Michele A Markley, Felipe Pedroso, Holly L Neville, Christopher W Snyder
Publikováno v:
Trauma Surgery & Acute Care Open, Vol 9, Iss 1 (2024)
Background Golf carts (GCs) and all-terrain vehicles (ATVs) are popular forms of personal transport. Although ATVs are considered adventurous and dangerous, GCs are perceived to be safer. Anecdotal experience suggests increasing numbers of both GC an
Externí odkaz:
https://doaj.org/article/c05f8028528446c0895c3133805b3950
Autor:
Emily M. Esquea, Lorela Ciraku, Riley G. Young, Jessica Merzy, Alexandra N. Talarico, Nusaiba N. Ahmed, Mangalam Karuppiah, Anna Ramesh, Adam Chatoff, Claudia V. Crispim, Adel A. Rashad, Simon Cocklin, Nathaniel W. Snyder, Joris Beld, Nicole L. Simone, Mauricio J. Reginato, Alexej Dick
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Breast cancer brain metastasis (BCBM) typically results in an end-stage diagnosis and is hindered by a lack of brain-penetrant drugs. Tumors in the brain rely on the conversion of acetate to acetyl-CoA by the enzyme acetyl-CoA synthetase 2 (ACSS2), a
Externí odkaz:
https://doaj.org/article/4ae2b15c3c5446188251b5c916b863e7
Autor:
Xianwei Wang, Lu Liu, Xiaohua Jiang, Jason Saredy, Hang Xi, Ramon Cueto, Danni Sigler, Mohsin Khan, Sheng Wu, Yong Ji, Nathaniel W. Snyder, Wenhui Hu, Xiaofeng Yang, Hong Wang
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-17 (2023)
Abstract Background Hyperhomocysteinemia (HHcy) has been linked to development of Alzheimer’s disease (AD) neuropathologically characterized by the accumulation of amyloid β (Aβ). Microglia (MG) play a crucial role in uptake of Aβ fibrils, and i
Externí odkaz:
https://doaj.org/article/2f25920bcdce4d459ea752eb0ce81137
Autor:
Marissa N. Trujillo, Erin Q. Jennings, Emely A. Hoffman, Hao Zhang, Aiden M. Phoebe, Grace E. Mastin, Naoya Kitamura, Julie A. Reisz, Emily Megill, Daniel Kantner, Mariola M. Marcinkiewicz, Shannon M. Twardy, Felicidad Lebario, Eli Chapman, Rebecca L. McCullough, Angelo D'Alessandro, Nathaniel W. Snyder, Darren A. Cusanovich, James J. Galligan
Publikováno v:
Molecular Metabolism, Vol 81, Iss , Pp 101888- (2024)
Chronic, systemic inflammation is a pathophysiological manifestation of metabolic disorders. Inflammatory signaling leads to elevated glycolytic flux and a metabolic shift towards aerobic glycolysis and lactate generation. This rise in lactate corres
Externí odkaz:
https://doaj.org/article/2715064b1deb49e1a938eed2068d8bb9
Autor:
Xuepeng Wei, Kollin Schultz, Hannah L. Pepper, Emily Megill, Austin Vogt, Nathaniel W. Snyder, Ronen Marmorstein
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract ATP citrate lyase (ACLY) is the predominant nucleocytosolic source of acetyl-CoA and is aberrantly regulated in many diseases making it an attractive therapeutic target. Structural studies of ACLY reveal a central homotetrameric core citrate
Externí odkaz:
https://doaj.org/article/e155289889a04189ae19747da2f8883c
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 22 (2023)
Cardiac metabolism provides effects that extend beyond the transformation of energy for the heart to operate effectively. Some metabolites also function as signaling molecules and exert transcriptional changes. Heart failure is a progressive patholog
Externí odkaz:
https://doaj.org/article/6289a5edb5a34c94a40a3cfa42848e47
Autor:
Yifan Lu, Yu Sun, Fatma Saaoud, Ying Shao, Keman Xu, Xiaohua Jiang, Sheng Wu, Jun Yu, Nathaniel W. Snyder, Ling Yang, Xinghua Mindy Shi, Huaqing Zhao, Hong Wang, Xiaofeng Yang
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
To determine the roles of endoplasmic reticulum (ER) stress and trained immunity, we performed transcriptome analyses on the thoracic aorta (TA) and abdominal aorta (AA) from the angiotensin II (Ang II)-HFD-ApoE-KO aneurysm model and made significant
Externí odkaz:
https://doaj.org/article/c85967b978be4ba9a3dd6e4e1dd1d757
Publikováno v:
npj Clean Water, Vol 5, Iss 1, Pp 1-17 (2022)
Abstract The energy-consuming and carbon-intensive wastewater treatment plants could become significant energy producers and recycled organic and metallic material generators, thereby contributing to broad sustainable development goals, the circular
Externí odkaz:
https://doaj.org/article/7ccf3e64a7a5491db69f3f6f8c1be213