Zobrazeno 1 - 10
of 485
pro vyhledávání: '"P. W. Ryan"'
Autor:
Choi, H. James, Lo, Teresa W., Cutler, Kevin J., Huang, Dean, Will, W. Ryan, Wiggins, Paul A.
Protein expression levels optimize cell fitness: Too low an expression level of essential proteins will slow growth by compromising essential processes; whereas overexpression slows growth by increasing the metabolic load. This trade-off naively pred
Externí odkaz:
http://arxiv.org/abs/2408.11952
Autor:
Safai, Apoorva, Jonaitis, Erin, Langhough, Rebecca E, Buckingham, William R, Johnson, Sterling C., Powell, W. Ryan, Kind, Amy J. H., Bendlin, Barbara B., Tiwari, Pallavi
Neighborhood disadvantage is associated with worse health and cognitive outcomes. Morphological similarity network (MSN) is a promising approach to elucidate cortical network patterns underlying complex cognitive functions. We hypothesized that MSNs
Externí odkaz:
http://arxiv.org/abs/2406.13822
In this work, the effect of electron-phonon (e-ph) coupling on both electron and phonon transport of metals is investigated via first principles calculations. A Monte-Carlo (MC) approach for solving the coupled electron-phonon Boltzmann transport equ
Externí odkaz:
http://arxiv.org/abs/2402.08150
Autor:
C. W. Ryan, S. L. Regan, E. F. Mills, B. T. McGrath, E. Gong, Y. T. Lai, J. B. Sheingold, K. Patel, T. Horowitz, A. Moccia, Y. C. Tsan, A. Srivastava, S. L. Bielas
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Polycomb repressive complex 1 (PRC1) modifies chromatin through catalysis of histone H2A lysine 119 monoubiquitination (H2AK119ub1). RING1 and RNF2 interchangeably serve as the catalytic subunit within PRC1. Pathogenic missense variants in P
Externí odkaz:
https://doaj.org/article/f80289b205214743a39021e064e5f307
Autor:
Young Kwang Chae, Megan Othus, Sandip Pravin Patel, David E. Gerber, Tawee Tanvetyanon, Hye Sung Kim, Liam Il-Young Chung, Christine M. McLeod, Gabby Lopez, Helen X. Chen, Elad Sharon, Howard Streicher, Cristopher W. Ryan, Charles D. Blanke, Razelle Kurzrock
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 16 (2024)
Background: Anti-programmed death-1 (PD-1)/cytotoxic T lymphocyte antigen-4 antibodies are efficacious in various malignancies. Objectives: This study presents the first results of ipilimumab–nivolumab in invasive mucinous or non-mucinous lepidic a
Externí odkaz:
https://doaj.org/article/c89726aa1d404f1491a28f4c3b4cc7ad
Autor:
Ziyin Tang, Donghai Liang, Emily L. Deubler, Jeremy A. Sarnat, Sabrina S. Chow, W. Ryan Diver, Ying Wang
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background A better understanding of lung cancer etiology and the development of screening biomarkers have important implications for lung cancer prevention. Methods We included 623 matched case–control pairs from the Cancer Prevention Stu
Externí odkaz:
https://doaj.org/article/74689b61869646afb2d9378af3f86ead
Autor:
Howard Streicher, Elad Sharon, Razelle Kurzrock, Young Kwang Chae, Megan Othus, Sandip Patel, Christine McLeod, Charles Blanke, Benjamin Powers, Chung-Tsen Hsueh, Helen X Chen, Hye Sung Kim, Liam Il-Young Chung, Christopher W Ryan, Rangaswamy Govindarajan, Silvana Bucur
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 9 (2024)
Background Dual inhibition using anti-programmed death-1 (PD-1) and anti-cytotoxic T-lymphocyte antigen-4 (CTLA-4) checkpoint inhibitors has proven effective in many cancers. However, its efficacy in rare solid cancers remains unclear. Desmoid tumors
Externí odkaz:
https://doaj.org/article/ae531706fd0f41aba22cfb80da0bf6da
Autor:
Donald Rees, D. Matthew Gianferante, Jung Kim, Theodora Stavrou, Gregory Reaman, Yadav Sapkota, M. Monica Gramatges, Lindsay M. Morton, Melissa M. Hudson, Gregory T. Armstrong, Neal D. Freedman, Wen-Yi Huang, W. Ryan Diver, Adriana Lori, Wen Luo, Belynda D. Hicks, Jia Liu, Amy A. Hutchinson, Alisa M. Goldstein, Lisa Mirabello
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundMedulloblastoma is the most common malignant brain tumor in children. Most cases are sporadic, but well characterized germline alterations in APC, ELP1, GPR161, PTCH1, SUFU, and TP53 predispose to medulloblastoma. However, knowledge about p
Externí odkaz:
https://doaj.org/article/f19e939d15a6499c95303648c3dec928
Autor:
Howard Streicher, Elad Sharon, Razelle Kurzrock, Young Kwang Chae, Benjamin Tan, Megan Othus, Christine McLeod, Charles Blanke, Helen X Chen, Sandip P Patel, Gabby Lopez, Tridu Huynh, Timothy Kuzel, Christopher W Ryan
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 7 (2024)
Objectives Multiple common cancers benefit from immunotherapy; however, less is known about efficacy in rare tumors. We report the results of the adrenocortical carcinoma cohort of NCI/SWOG S1609 Dual Anti-CTLA-4 and Anti-PD-1 blockade in Rare Tumors
Externí odkaz:
https://doaj.org/article/200c10085aef41019eb8269d72020f4d
Autor:
Lucas E. Price, Brett P. Skelly, Erin E. Morrison, Colin P. Carpenter, Christopher W. Ryan, Christopher T. Rota
Publikováno v:
Wildlife Society Bulletin, Vol 48, Iss 2, Pp n/a-n/a (2024)
Abstract Wildlife space use is a key component to consider when determining effective conservation and management practices. Home range size and resource selection can vary temporally and spatially depending on mortality risks in the area and access
Externí odkaz:
https://doaj.org/article/1a69df7d0d7f45c0b35d574d4e4d8ef5