Zobrazeno 1 - 10
of 19
pro vyhledávání: '"P. W. Partridge"'
Autor:
Arun Chandramohan, Hubert Josien, Tsz Ying Yuen, Ruchia Duggal, Diana Spiegelberg, Lin Yan, Yu-Chi Angela Juang, Lan Ge, Pietro G. Aronica, Hung Yi Kristal Kaan, Yee Hwee Lim, Andrea Peier, Brad Sherborne, Jerome Hochman, Songnian Lin, Kaustav Biswas, Marika Nestor, Chandra S. Verma, David P. Lane, Tomi K. Sawyer, Robert Garbaccio, Brian Henry, Srinivasaraghavan Kannan, Christopher J. Brown, Charles W. Johannes, Anthony W. Partridge
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Although stapled α-helical peptides can address challenging targets, their advancement is impeded by poor understandings for making them cell permeable while avoiding off-target toxicities. By synthesizing >350 molecules, we present workflo
Externí odkaz:
https://doaj.org/article/244b34e3aef44b508696598d0927724f
Autor:
Katrine Ingelshed, Marit M. Melssen, Pavitra Kannan, Arun Chandramohan, Anthony W. Partridge, Long Jiang, Fredrik Wermeling, David P. Lane, Marika Nestor, Diana Spiegelberg
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109862- (2024)
Summary: Immunotherapy has revolutionized cancer treatment but its efficacy depends on a robust immune response in the tumor. Silencing of the tumor suppressor p53 is common in tumors and can affect the recruitment and activation of different immune
Externí odkaz:
https://doaj.org/article/a6f5c387d3ed4365a35bb503c9592eba
Autor:
Stephen H. Kasper, Stephanie Otten, Brian Squadroni, Cionna Orr‐Terry, Yi Kuang, Lily Mussallem, Lan Ge, Lin Yan, Srinivasaraghavan Kannan, Chandra S. Verma, Christopher J. Brown, Charles W. Johannes, David P. Lane, Arun Chandramohan, Anthony W. Partridge, Lee R. Roberts, Hubert Josien, Alex G. Therien, Erik C. Hett, Bonnie J. Howell, Andrea Peier, Xi Ai, Jason Cassaday
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 5, Pp n/a-n/a (2023)
Abstract Cyclic peptides are poised to target historically difficult to drug intracellular protein–protein interactions, however, their general cell impermeability poses a challenge for characterizing function. Recent advances in microfluidics have
Externí odkaz:
https://doaj.org/article/4ede5586001347c2a4d447e4b2a014ec
Autor:
Simon Ng, Shuhui Lim, Adrian Chong Nyi Sim, Ruban Mangadu, Ally Lau, Chunsheng Zhang, Sarah Bollinger Martinez, Arun Chandramohan, U-Ming Lim, Samantha Shu Wen Ho, Shih Chieh Chang, Pooja Gopal, Lewis Z. Hong, Adam Schwaid, Aaron Zefrin Fernandis, Andrey Loboda, Cai Li, Uyen Phan, Brian Henry, Anthony W. Partridge
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Immune checkpoint blockade (ICB) leads to durable and complete tumour regression in some patients but in others gives temporary, partial or no response. Accordingly, significant efforts are underway to identify tumour-intrinsic mechanisms un
Externí odkaz:
https://doaj.org/article/0fbf12d4ecc444c2912ab9c47b00b517
Autor:
Shuhui Lim, Regina Khoo, Yu-Chi Juang, Pooja Gopal, Huibin Zhang, Constance Yeo, Khong Ming Peh, Jinkai Teo, Simon Ng, Brian Henry, Anthony W. Partridge
Publikováno v:
ACS Central Science, Vol 7, Iss 2, Pp 274-291 (2020)
Externí odkaz:
https://doaj.org/article/5f5d414c219444a1a1f0c50dacdb5325
Autor:
Anthony W. Partridge, Hung Yi Kristal Kaan, Yu-Chi Juang, Ahmad Sadruddin, Shuhui Lim, Christopher J. Brown, Simon Ng, Dawn Thean, Fernando Ferrer, Charles Johannes, Tsz Ying Yuen, Srinivasaraghavan Kannan, Pietro Aronica, Yaw Sing Tan, Mohan R. Pradhan, Chandra S. Verma, Jerome Hochman, Shiying Chen, Hui Wan, Sookhee Ha, Brad Sherborne, David P. Lane, Tomi K. Sawyer
Publikováno v:
Molecules, Vol 24, Iss 12, p 2292 (2019)
Stapled α-helical peptides represent an emerging superclass of macrocyclic molecules with drug-like properties, including high-affinity target binding, protease resistance, and membrane permeability. As a model system for probing the chemical space
Externí odkaz:
https://doaj.org/article/76dd0b05d6584b64a066db0da685651e
Publikováno v:
International Journal for Numerical Methods in Engineering. 50:1455-1468
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5911e3caf8e99c0232e5c6e254d93784
https://doi.org/10.1002/1097-0207(20010228)50:6<1455::aid-nme80>3.0.co
https://doi.org/10.1002/1097-0207(20010228)50:6<1455::aid-nme80>3.0.co
Publikováno v:
Advances in Engineering Software. 13:2-16
The dual reciprocity method (DRM) is a general technique for taking domain integrals to the boundary in BEM analysis. In this paper it is applied to the eigenvalue analysis of Helmholtz problems. A solution procedure is presented which avoids the com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::875ebad42890f69dfc40a1c110e5f0e8
https://doi.org/10.1016/0965-9978(91)90002-j
https://doi.org/10.1016/0965-9978(91)90002-j
Publikováno v:
Communications in Applied Numerical Methods. 6:83-92
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d98141c9a80942c3ad27028daaa943ac
https://doi.org/10.1002/cnm.1630060204
https://doi.org/10.1002/cnm.1630060204
Publikováno v:
The Dual Reciprocity Boundary Element Method ISBN: 9781851667000
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f747b8eafc1c1ebdb085225cae91cbe7
https://doi.org/10.1007/978-94-011-3690-7_1
https://doi.org/10.1007/978-94-011-3690-7_1
