Zobrazeno 1 - 10
of 40
pro vyhledávání: '"P. W. McNamara"'
Autor:
Nian E. Zhou, Su Tang, Xuelin Bian, Maloy K. Parai, Inna V. Krieger, Armando Flores, Pradeep K. Jaiswal, Radha Bam, Jeremy L. Wood, Zhe Shi, Laura J. Stevens, Trevor Scobey, Meghan V. Diefenbacher, Fernando R. Moreira, Thomas J. Baric, Arjun Acharya, Joonyoung Shin, Manish M. Rathi, Karen C. Wolff, Laura Riva, Malina A. Bakowski, Case W. McNamara, Nicholas J. Catanzaro, Rachel L. Graham, David C. Schultz, Sara Cherry, Yoshihiro Kawaoka, Peter J. Halfmann, Ralph S. Baric, Mark R. Denison, Timothy P. Sheahan, James C. Sacchettini
Publikováno v:
Cell Reports, Vol 43, Iss 11, Pp 114929- (2024)
Summary: Safe, effective, and low-cost oral antiviral therapies are needed to treat those at high risk for developing severe COVID-19. To that end, we performed a high-throughput screen to identify non-peptidic, non-covalent inhibitors of the SARS-Co
Externí odkaz:
https://doaj.org/article/fee5e4e3bedd475abadbb75db127898b
Autor:
Reagan M. Mogire, Silviane A. Miruka, Dennis W. Juma, Case W. McNamara, Ben Andagalu, Jeremy N. Burrows, Elodie Chenu, James Duffy, Bernhards R. Ogutu, Hoseah M. Akala
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-13 (2024)
Abstract Drug discovery is an intricate and costly process. Repurposing existing drugs and active compounds offers a viable pathway to develop new therapies for various diseases. By leveraging publicly available biomedical information, it is possible
Externí odkaz:
https://doaj.org/article/9abd7be432b44ac9ad401606323a2e80
Autor:
Muhammad M Hasan, Ethan B Mattice, José E Teixeira, Rajiv S Jumani, Erin E Stebbins, Connor E Klopfer, Sebastian E Franco, Melissa S Love, Case W McNamara, Christopher D Huston
Publikováno v:
PLoS Pathogens, Vol 20, Iss 4, p e1011906 (2024)
The apicomplexan parasite Cryptosporidium is a leading cause of childhood diarrhea in developing countries. Current treatment options are inadequate and multiple preclinical compounds are being actively pursued as potential drugs for cryptosporidiosi
Externí odkaz:
https://doaj.org/article/858bd4c9e6174385846885aacbdecc07
Autor:
Mario Carucci, Julien Duez, Joel Tarning, Irene García-Barbazán, Aurélie Fricot-Monsinjon, Abdoulaye Sissoko, Lucie Dumas, Pablo Gamallo, Babette Beher, Pascal Amireault, Michael Dussiot, Ming Dao, Mitchell V. Hull, Case W. McNamara, Camille Roussel, Papa Alioune Ndour, Laura Maria Sanz, Francisco Javier Gamo, Pierre Buffet
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Authors propose their splenic mimetic filtration method, microsphiltration, and utilise this approach in a drug-screen, to identify compounds that induce a stiffening effect on Plasmodium falciparum-infected erythrocytes. They proceed to assess safet
Externí odkaz:
https://doaj.org/article/12698d4c89d84fc19fe9d82eeccb5f13
Autor:
Paul Kelly, William A Petri, Rashidul Haque, Ibrahim A Khalil, Lynn Barrett, Tom Kennedy, Timothy Wells, Christopher D Huston, James Platts-mills, Grace S Yang, Richard Omore, Ian H Gilbert, Sumiti Vinayak, Boris Striepen, Ujjini H Manjunatha, Wesley C Van Voorhis, Samuel L M Arnold, Beatriz Baragana, Frederick S Buckner, Jeremy D Burrows, Maria A Caravedo, Ryan Choi, Robert K M Choy, Eugenio de Hostos, Thierry Diagana, Suzanne Duce, Matthew A Hulverson, Pui-Ying Iroh Tam, Minju Kim, Poonum Korpe, Benoît Laleu, Diana Lalika, Fabrice Laurent, Case W McNamara, Marvin J Meyers, Roberta M O’Connor, Kayode K Ojo, Philipp Olias, Nede Ovbiebo, Mattie C Pawlowic, Gladys Queen, Divya Rao, Kevin Reed, Michael W Riggs, Jennifer L Roxas, Adam Sateriale, Deborah A Schaefer, L David Sibley, Jonathan M Spector, Chris Tonkin, Timilehin E Toye, Saul Tzipori, A Clinton White
Publikováno v:
BMJ Global Health, Vol 8, Iss 8 (2023)
Externí odkaz:
https://doaj.org/article/540e409047fd43baae051b1737c1bbc5
Publikováno v:
Microorganisms, Vol 11, Iss 12, p 2845 (2023)
Leishmaniasis is a group of vector-borne, parasitic diseases caused by over 20 species of the protozoan Leishmania spp. The three major disease classifications, cutaneous, visceral, and mucocutaneous, have a range of clinical manifestations from self
Externí odkaz:
https://doaj.org/article/de5072f6830642a2935a0e06b858bbf0
Autor:
Sabine Ottilie, Madeline R. Luth, Erich Hellemann, Gregory M. Goldgof, Eddy Vigil, Prianka Kumar, Andrea L. Cheung, Miranda Song, Karla P. Godinez-Macias, Krypton Carolino, Jennifer Yang, Gisel Lopez, Matthew Abraham, Maureen Tarsio, Emmanuelle LeBlanc, Luke Whitesell, Jake Schenken, Felicia Gunawan, Reysha Patel, Joshua Smith, Melissa S. Love, Roy M. Williams, Case W. McNamara, William H. Gerwick, Trey Ideker, Yo Suzuki, Dyann F. Wirth, Amanda K. Lukens, Patricia M. Kane, Leah E. Cowen, Jacob D. Durrant, Elizabeth A. Winzeler
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Ottilie et al. employ an experimental evolution approach to investigate the role of transcription factors in yeast chemical resistance. Most emergent mutations in resistant strains were enriched in transcription factor coding genes, highlighting thei
Externí odkaz:
https://doaj.org/article/9094da31e4444ec8861d9e3850fe0c08
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
The Parkinson's Disease Activities of Daily Living, Interference, and Dependence Instrument© (PD-AID) is a patient-reported outcome (PRO) instrument, recently developed to assess the clinical benefit of Parkinson's Disease (PD) treatment. The PD-AID
Externí odkaz:
https://doaj.org/article/51213a711f324af1b5f73b483661bca2
Autor:
Malina A. Bakowski, Nathan Beutler, Karen C. Wolff, Melanie G. Kirkpatrick, Emily Chen, Tu-Trinh H. Nguyen, Laura Riva, Namir Shaabani, Mara Parren, James Ricketts, Anil K. Gupta, Kastin Pan, Peiting Kuo, MacKenzie Fuller, Elijah Garcia, John R. Teijaro, Linlin Yang, Debashis Sahoo, Victor Chi, Edward Huang, Natalia Vargas, Amanda J. Roberts, Soumita Das, Pradipta Ghosh, Ashley K. Woods, Sean B. Joseph, Mitchell V. Hull, Peter G. Schultz, Dennis R. Burton, Arnab K. Chatterjee, Case W. McNamara, Thomas F. Rogers
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Here, the authors perform repurposing screens of the ReFRAME drug library in two cell lines and identify inhibitors of SARS-CoV-2 infection. Antiviral activity of prodrug MK-4482 is confirmed in hamsters.
Externí odkaz:
https://doaj.org/article/b79629899ac84da0ab6e053c69619b49
Autor:
Marc P. Hübner, Emma Gunderson, Ian Vogel, Christina A. Bulman, K.C. Lim, Marianne Koschel, Alexandra Ehrens, Stefan J. Frohberger, Martina Fendler, Nancy Tricoche, Denis Voronin, Andrew Steven, Victor Chi, Malina A. Bakowski, Ashley K. Woods, H. Michael Petrassi, Case W. McNamara, Brenda Beerntsen, Laura Chappell, William Sullivan, Mark J. Taylor, Joseph D. Turner, Achim Hoerauf, Sara Lustigman, Judy A. Sakanari
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 12, Iss , Pp 18-27 (2020)
The quinazolines CBR417 and CBR490 were previously shown to be potent anti-wolbachials that deplete Wolbachia endosymbionts of filarial nematodes and present promising pre-clinical candidates for human filarial diseases such as onchocerciasis. In the
Externí odkaz:
https://doaj.org/article/ae0698b9586a42138cd1a78a22ad6053